Mechanism of cis-inhibition of polyQ fibrillation by polyP: PPII oligomers and the hydrophobic effect.
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Improved atomistic Monte Carlo simulations demonstrate that poly-L-proline adopts heterogeneous ensembles of conformations of semi-rigid segments interrupted by kinks.Polyglutamine-rich suppressors of huntingtin toxicity act upstream of Hsp70 and Sti1 in spatial quality control of amyloid-like proteins.Monomeric, oligomeric and polymeric proteins in huntington disease and other diseases of polyglutamine expansionThe aggregation-enhancing huntingtin N-terminus is helical in amyloid fibrils.Assessing the contribution of heterogeneous distributions of oligomers to aggregation mechanisms of polyglutamine peptidesAre long-range structural correlations behind the aggregration phenomena of polyglutamine diseases?Polyglutamine amyloid core boundaries and flanking domain dynamics in huntingtin fragment fibrils determined by solid-state nuclear magnetic resonance.Aggregation kinetics of interrupted polyglutamine peptidesPolyglutamine- and temperature-dependent conformational rigidity in mutant huntingtin revealed by immunoassays and circular dichroism spectroscopySolid-State Nuclear Magnetic Resonance on the Static and Dynamic Domains of Huntingtin Exon-1 Fibrils.The interaction of polyglutamine peptides with lipid membranes is regulated by flanking sequences associated with huntingtinNanoscale studies link amyloid maturity with polyglutamine diseases onset.Investigating Mutations to Reduce Huntingtin Aggregation by Increasing Htt-N-Terminal Stability and Weakening Interactions with PolyQ Domain.Physical chemistry of polyglutamine: intriguing tales of a monotonous sequence.Polyglutamine Aggregation in Huntington Disease: Does Structure Determine Toxicity?Emerging β-Sheet Rich Conformations in Supercompact Huntingtin Exon-1 Mutant Structures.Proteins Containing Expanded Polyglutamine Tracts and Neurodegenerative Disease.Self-assembly of 33-mer gliadin peptide oligomers.Chaperone-like N-methyl peptide inhibitors of polyglutamine aggregationControl of the structural landscape and neuronal proteotoxicity of mutant Huntingtin by domains flanking the polyQ tract.The 17-residue-long N terminus in huntingtin controls step-wise aggregation in solution and on membranes via different mechanisms.Identification of a novel site of interaction between ataxin-3 and the amyloid aggregation inhibitor polyglutamine binding peptide 1.Circular dichroism and electron microscopy studies in vitro of 33-mer gliadin peptide revealed secondary structure transition and supramolecular organization.
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P2860
Mechanism of cis-inhibition of polyQ fibrillation by polyP: PPII oligomers and the hydrophobic effect.
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article científic
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article scientifique
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articolo scientifico
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artigo científico
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bilimsel makale
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scientific article published on October 2009
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vedecký článok
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vetenskaplig artikel
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videnskabelig artikel
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vědecký článek
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name
Mechanism of cis-inhibition of ...... rs and the hydrophobic effect.
@en
Mechanism of cis-inhibition of ...... rs and the hydrophobic effect.
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type
label
Mechanism of cis-inhibition of ...... rs and the hydrophobic effect.
@en
Mechanism of cis-inhibition of ...... rs and the hydrophobic effect.
@nl
prefLabel
Mechanism of cis-inhibition of ...... rs and the hydrophobic effect.
@en
Mechanism of cis-inhibition of ...... rs and the hydrophobic effect.
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P2093
P2860
P1433
P1476
Mechanism of cis-inhibition of ...... rs and the hydrophobic effect.
@en
P2093
Gregory D Darnell
JohnMark Derryberry
Josh W Kurutz
Stephen C Meredith
P2860
P304
P356
10.1016/J.BPJ.2009.07.062
P407
P577
2009-10-01T00:00:00Z