Oversized AAV transductifon is mediated via a DNA-PKcs-independent, Rad51C-dependent repair pathway. - Wikidata - wikimedia - TriplyDB

Oversized AAV transductifon is mediated via a DNA-PKcs-independent, Rad51C-dependent repair pathway.

Oversized AAV transductifon is mediated via a DNA-PKcs-independent, Rad51C-dependent repair pathway.

http://www.wikidata.org/entity/Q37393799

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Adeno-associated Virus as a Mammalian DNA Vector Gene therapy of inherited retinal degenerations: prospects and challenges Vector platforms for gene therapy of inherited retinopathies.Bioengineered coagulation factor VIII enables long-term correction of murine hemophilia A following liver-directed adeno-associated viral vector delivery.Gene Therapy of ABCA4-Associated Diseases.Identification and Validation of Small Molecules That Enhance Recombinant Adeno-associated Virus Transduction following High-Throughput Screens.Expressing Transgenes That Exceed the Packaging Capacity of Adeno-Associated Virus Capsids.The impact of minimally oversized adeno-associated viral vectors encoding human factor VIII on vector potency in vivo.Effective delivery of large genes to the retina by dual AAV vectors.Dual adeno-associated virus vectors result in efficient in vitro and in vivo expression of an oversized gene, MYO7A.Hip region muscular dystrophy and emergence of motor deficits in dysferlin-deficient Bla/J mice.The function of DNA binding protein nucleophosmin in AAV replication Characteristics of Minimally Oversized Adeno-Associated Virus Vectors Encoding Human Factor VIII Generated Using Producer Cell Lines and Triple Transfection.Structure-Based Designed Nano-Dysferlin Significantly Improves Dysferlinopathy in BLA/J Mice.Copackaging of multiple adeno-associated viral vectors in a single production step.Genome editing in human stem cells.Optimization of adeno-associated virus vector-mediated gene transfer to the respiratory tract.A fragmented adeno-associated viral dual vector strategy for treatment of diseases caused by mutations in large genes leads to expression of hybrid transcripts.A comparison of AAV strategies distinguishes overlapping vectors for efficient systemic delivery of the 6.2 kb Dysferlin coding sequence Delivering Transgenic DNA Exceeding the Carrying Capacity of AAV Vectors.Efficient gene delivery to the cone-enriched pig retina by dual AAV vectors.Gene therapy approaches for prevention of retinal degeneration in Usher syndrome.Efficient central nervous system AAVrh10-mediated intrathecal gene transfer in adult and neonate rats.AAV vector-meditated expression of HLA-G reduces injury-induced corneal vascularization, immune cell infiltration, and fibrosis.Inhibition of antigen presentation during AAV gene therapy using virus peptides.Emerging Issues in AAV-Mediated In Vivo Gene Therapy.Adeno-associated Virus (AAV) Dual Vector Strategies for Gene Therapy Encoding Large Transgenes.

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Oversized AAV transductifon is mediated via a DNA-PKcs-independent, Rad51C-dependent repair pathway.

http://www.wikidata.org/entity/Q37393799

description

article científic

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article scientifique

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articolo scientifico

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artigo científico

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bilimsel makale

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scientific article published on 13 August 2013

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vedecký článok

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vetenskaplig artikel

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videnskabelig artikel

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vědecký článek

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name

Oversized AAV transductifon is ...... d51C-dependent repair pathway.

@en

Oversized AAV transductifon is ...... d51C-dependent repair pathway.

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type

label

Oversized AAV transductifon is ...... d51C-dependent repair pathway.

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Oversized AAV transductifon is ...... d51C-dependent repair pathway.

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prefLabel

Oversized AAV transductifon is ...... d51C-dependent repair pathway.

@en

Oversized AAV transductifon is ...... d51C-dependent repair pathway.

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Molecular Therapy

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Oversized AAV transductifon is ...... d51C-dependent repair pathway.

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Chaoying Yin

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Chengwen Li

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Isabella Bellon

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Isabelle Richard

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Marina Pryadkina

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Matthew L Hirsch

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Richard Jude Samulski

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Sai Chavala

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P2860

Identification and purification of two distinct complexes containing the five RAD51 paralogs

RAD51C is required for Holliday junction processing in mammalian cells

Interactions involving the Rad51 paralogs Rad51C and XRCC3 in human cells

In vitro packaging of adeno-associated virus DNA

Membrane-associated heparan sulfate proteoglycan is a receptor for adeno-associated virus type 2 virions

Packaging capacity of adeno-associated virus serotypes: impact of larger genomes on infectivity and postentry steps.

Complex formation by the human RAD51C and XRCC3 recombination repair proteins

Homologous recombination mediates functional recovery of dysferlin deficiency following AAV5 gene transfer

Autophosphorylation of the catalytic subunit of the DNA-dependent protein kinase is required for efficient end processing during DNA double-strand break repair.

RAD51C interacts with RAD51B and is central to a larger protein complex in vivo exclusive of RAD51

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scholarly article

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10.1038/MT.2013.184

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