Genetic variants and mutations of PPM1D control the response to DNA damage. - Wikidata - wikimedia - TriplyDB

Genetic variants and mutations of PPM1D control the response to DNA damage.

Genetic variants and mutations of PPM1D control the response to DNA damage.

http://www.wikidata.org/entity/Q37396919

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Wip1 phosphatase: between p53 and MAPK kinases pathways WIP1 phosphatase as pharmacological target in cancer therapy.Exome sequencing identifies somatic gain-of-function PPM1D mutations in brainstem gliomas.DOTS-Finder: a comprehensive tool for assessing driver genes in cancer genomes.Overexpression of wip1 is associated with biologic behavior in human clear cell renal cell carcinoma.The WIP1 oncogene promotes progression and invasion of aggressive medulloblastoma variants Wip1 phosphatase in breast cancer.Clinical significance of Wip1 overexpression and its association with the p38MAPK/p53/p16 pathway in NSCLC PPM1D exerts its oncogenic properties in human pancreatic cancer through multiple mechanisms.Truncating and missense PPM1D mutations in early-onset and/or familial/hereditary prostate cancer patients.Inhibition of WIP1 phosphatase sensitizes breast cancer cells to genotoxic stress and to MDM2 antagonist nutlin-3.Protein Phosphatase Magnesium-Dependent 1δ (PPM1D) Expression as a Prognostic Marker in Adult Supratentorial Diffuse Astrocytic and Oligodenroglial Tumors.Smaller protein, larger therapeutic potential: PPM1D as a new therapeutic target in brainstem glioma.

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Genetic variants and mutations of PPM1D control the response to DNA damage.

http://www.wikidata.org/entity/Q37396919

description

article científic

@ca

article scientifique

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articolo scientifico

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artigo científico

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bilimsel makale

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scientific article published on 18 July 2013

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vedecký článok

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vetenskaplig artikel

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videnskabelig artikel

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vědecký článek

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name

Genetic variants and mutations of PPM1D control the response to DNA damage.

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Genetic variants and mutations of PPM1D control the response to DNA damage.

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type

label

Genetic variants and mutations of PPM1D control the response to DNA damage.

@en

Genetic variants and mutations of PPM1D control the response to DNA damage.

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prefLabel

Genetic variants and mutations of PPM1D control the response to DNA damage.

@en

Genetic variants and mutations of PPM1D control the response to DNA damage.

@nl

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Genetic variants and mutations of PPM1D control the response to DNA damage

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P2093

Ahmed Sayadi

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Crissy Dudgeon

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Dmitry V Bulavin

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Ettore Appella

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Kan Tanoue

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Sathyavageeswaran Shreeram

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Sharlyn J Mazur

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P2860

The Wip1 Phosphatase acts as a gatekeeper in the p53-Mdm2 autoregulatory loop

PPM1D dephosphorylates Chk1 and p53 and abrogates cell cycle checkpoints

Crystal structure of the protein serine/threonine phosphatase 2C at 2.0 A resolution

Features and development of Coot

Amplification of PPM1D in human tumors abrogates p53 tumor-suppressor activity

Substrate specificity of the human protein phosphatase 2Cdelta, Wip1

Regulation of the antioncogenic Chk2 kinase by the oncogenic Wip1 phosphatase

Genome-wide array-based comparative genomic hybridization analysis of pancreatic adenocarcinoma: identification of genetic indicators that predict patient outcome

Mosaic PPM1D mutations are associated with predisposition to breast and ovarian cancer

Single nucleotide polymorphisms and the future of genetic epidemiology.

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2656-2664

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scholarly article

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10.4161/CC.25694

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16

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12

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Robert C Robinson

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2013-07-18T00:00:00Z

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254265499

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23907125

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3865055

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