The proteasome-associated deubiquitinating enzyme Usp14 is essential for the maintenance of synaptic ubiquitin levels and the development of neuromuscular junctions
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To build a synapse: signaling pathways in neuromuscular junction assemblyUbiquitin-Synaptobrevin Fusion Protein Causes Degeneration of Presynaptic Motor Terminals in MiceThe role of deubiquitinating enzymes in synaptic function and nervous system diseasesThe proteasome controls presynaptic differentiation through modulation of an on-site pool of polyubiquitinated conjugatesDysregulation of Ubiquitin-Proteasome System in Neurodegenerative DiseasesOver-expression of deubiquitinating enzyme USP14 in lung adenocarcinoma promotes proliferation through the accumulation of β-cateninBassoon and Piccolo maintain synapse integrity by regulating protein ubiquitination and degradationEnhancement of proteasome activity by a small-molecule inhibitor of USP14The ubiquitin-specific protease 14 (USP14) is a critical regulator of long-term memory formation.Ubiquitin-specific protease 14 regulates c-Jun N-terminal kinase signaling at the neuromuscular junctionUSP5/Leon deubiquitinase confines postsynaptic growth by maintaining ubiquitin homeostasis through UbiquilinCharacterization of the Brain 26S Proteasome and its Interacting ProteinsThe ubiquitin-proteasome pathway and synaptic plasticity.An optimal ubiquitin-proteasome pathway in the nervous system: the role of deubiquitinating enzymes.Role of ubiquitin-proteasome-mediated proteolysis in nervous system disease.Systematic analysis of the physiological importance of deubiquitinating enzymes.Local ubiquitin-proteasome-mediated proteolysis and long-term synaptic plasticity.Genetic background alters the severity and onset of neuromuscular disease caused by the loss of ubiquitin-specific protease 14 (usp14)Increasing expression and decreasing degradation of SMN ameliorate the spinal muscular atrophy phenotype in miceUbiquitination in postsynaptic function and plasticityBalancing act: deubiquitinating enzymes in the nervous system.Distinct effects of ubiquitin overexpression on NMJ structure and motor performance in mice expressing catalytically inactive USP14.Ubiquitin homeostasis is critical for synaptic development and functionMotor and Sensory Deficits in the teetering Mice Result from Mutation of the ESCRT Component HGSUbiquitin-specific protease 14 modulates degradation of cellular prion proteinAltered neurotransmitter release machinery in mice deficient for the deubiquitinating enzyme Usp14.Neurofilament Phosphorylation during Development and Disease: Which Came First, the Phosphorylation or the Accumulation?The emerging role of proteolysis in mitochondrial quality control and the etiology of Parkinson's disease.Ubp6 deubiquitinase controls conformational dynamics and substrate degradation of the 26S proteasome.Separating neuronal compartments gives clues as to local effect of ubiquitin conjugates in synaptogenesisHERC 1 Ubiquitin Ligase Mutation Affects Neocortical, CA3 Hippocampal and Spinal Cord Projection Neurons: An Ultrastructural Study.TMEM184b Promotes Axon Degeneration and Neuromuscular Junction Maintenance.Abnormally Small Neuromuscular Junctions in the Extraocular Muscles From Subjects With Idiopathic Nystagmus and Nystagmus Associated With Albinism.USP5 Is Dispensable for Monoubiquitin Maintenance in DrosophilaOverexpression of USP14 protease reduces I-κB protein levels and increases cytokine release in lung epithelial cells.Visualizing K48 Ubiquitination during Presynaptic Formation By Ubiquitination-Induced Fluorescence Complementation (UiFC).Neuronal ubiquitin homeostasisDeubiquitylases from genes to organism.Cellular ubiquitin pool dynamics and homeostasis.Neurofilament dynamics and involvement in neurological disorders.
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The proteasome-associated deubiquitinating enzyme Usp14 is essential for the maintenance of synaptic ubiquitin levels and the development of neuromuscular junctions
description
article científic
@ca
article scientifique
@fr
articolo scientifico
@it
artigo científico
@pt
bilimsel makale
@tr
scientific article published on September 2009
@en
vedecký článok
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vetenskaplig artikel
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videnskabelig artikel
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vědecký článek
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name
The proteasome-associated deub ...... ent of neuromuscular junctions
@en
The proteasome-associated deub ...... nt of neuromuscular junctions.
@nl
type
label
The proteasome-associated deub ...... ent of neuromuscular junctions
@en
The proteasome-associated deub ...... nt of neuromuscular junctions.
@nl
prefLabel
The proteasome-associated deub ...... ent of neuromuscular junctions
@en
The proteasome-associated deub ...... nt of neuromuscular junctions.
@nl
P2093
P2860
P1476
The proteasome-associated deub ...... ent of neuromuscular junctions
@en
P2093
Julie A Wilson
Lu-Ning Qin
Ping-Chung Chen
Scott M Wilson
Xiao-Ming Li
P2860
P304
10909-10919
P356
10.1523/JNEUROSCI.2635-09.2009
P407
P577
2009-09-01T00:00:00Z