Flexibility and charge asymmetry in the activation loop of Src tyrosine kinases
about
SRC-family tyrosine kinases in oogenesis, oocyte maturation and fertilization: an evolutionary perspectiveCracking the Molecular Origin of Intrinsic Tyrosine Kinase Activity through Analysis of Pathogenic Gain-of-Function MutationsMutation D816V alters the internal structure and dynamics of c-KIT receptor cytoplasmic region: implications for dimerization and activation mechanismsHotspot mutations in KIT receptor differentially modulate its allosterically coupled conformational dynamics: impact on activation and drug sensitivityThe Activation of c-Src Tyrosine Kinase: Conformational Transition Pathway and Free Energy Landscape.Autoinhibition of Bruton's tyrosine kinase (Btk) and activation by soluble inositol hexakisphosphate.Locking the active conformation of c-Src kinase through the phosphorylation of the activation loopHierarchical modeling of activation mechanisms in the ABL and EGFR kinase domains: thermodynamic and mechanistic catalysts of kinase activation by cancer mutations.Mapping the conformational transition in Src activation by cumulating the information from multiple molecular dynamics trajectoriesComputational modeling of allosteric communication reveals organizing principles of mutation-induced signaling in ABL and EGFR kinases.Sequence and structure signatures of cancer mutation hotspots in protein kinasesNew pyrazolo-[3,4-d]-pyrimidine derivative Src kinase inhibitors lead to cell cycle arrest and tumor growth reduction of human medulloblastoma cells.Allosteric communication across the native and mutated KIT receptor tyrosine kinase."DFG-flip" in the insulin receptor kinase is facilitated by a helical intermediate state of the activation loop.αC helix as a switch in the conformational transition of Src/CDK-like kinase domains.Conformational Selection and Induced Fit Mechanisms in the Binding of an Anticancer Drug to the c-Src KinasemiR-26a desensitizes non-small cell lung cancer cells to tyrosine kinase inhibitors by targeting PTPN13.Advanced ensemble modelling of flexible macromolecules using X-ray solution scattering.Computational study of the W260A activating mutant of Src tyrosine kinase.Atomistic view of the conformational activation of Src kinase using the string method with swarms-of-trajectories.
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Flexibility and charge asymmetry in the activation loop of Src tyrosine kinases
description
article científic
@ca
article scientifique
@fr
articolo scientifico
@it
artigo científico
@pt
bilimsel makale
@tr
scientific article published on February 2009
@en
vedecký článok
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vetenskaplig artikel
@sv
videnskabelig artikel
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vědecký článek
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name
Flexibility and charge asymmetry in the activation loop of Src tyrosine kinases
@en
Flexibility and charge asymmetry in the activation loop of Src tyrosine kinases.
@nl
type
label
Flexibility and charge asymmetry in the activation loop of Src tyrosine kinases
@en
Flexibility and charge asymmetry in the activation loop of Src tyrosine kinases.
@nl
prefLabel
Flexibility and charge asymmetry in the activation loop of Src tyrosine kinases
@en
Flexibility and charge asymmetry in the activation loop of Src tyrosine kinases.
@nl
P2860
P356
P1433
P1476
Flexibility and charge asymmetry in the activation loop of Src tyrosine kinases
@en
P2093
Benoît Roux
P2860
P304
P356
10.1002/PROT.22153
P407
P577
2009-02-01T00:00:00Z