Common features between diabetes mellitus and Alzheimer's disease.
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Blockade of islet amyloid polypeptide fibrillation and cytotoxicity by the secretory chaperones 7B2 and proSAASMolecular and biochemical trajectories from diabetes to Alzheimer's disease: A critical appraisalInhibition of the mitochondrial enzyme ABAD restores the amyloid-β-mediated deregulation of estradiolDeregulation of CREB signaling pathway induced by chronic hyperglycemia downregulates NeuroD transcriptionDiabetic db/db mice exhibit central nervous system and peripheral molecular alterations as seen in neurological disordersAmyloid β (Aβ) peptide directly activates amylin-3 receptor subtype by triggering multiple intracellular signaling pathwaysExperimental diabetes mellitus exacerbates tau pathology in a transgenic mouse model of Alzheimer's diseaseNeprilysin impedes islet amyloid formation by inhibition of fibril formation rather than peptide degradation.Brain aging and AD-like pathology in streptozotocin-induced diabetic rats.GLP-1 receptor stimulation reduces amyloid-beta peptide accumulation and cytotoxicity in cellular and animal models of Alzheimer's disease.The Mitochondrial Peptidase Pitrilysin Degrades Islet Amyloid Polypeptide in Beta-Cells.Actions of β-amyloid protein on human neurons are expressed through the amylin receptor.Tau in Alzheimer disease and related tauopathies.Profiling murine tau with 0N, 1N and 2N isoform-specific antibodies in brain and peripheral organs reveals distinct subcellular localization, with the 1N isoform being enriched in the nucleus.Increased protein aggregation in Zucker diabetic fatty rat brain: identification of key mechanistic targets and the therapeutic application of hydrogen sulfide.Interactive effects of apolipoprotein E4 and diabetes risk on later myelinating white matter regions in neurologically healthy older aged adultsModes of Aβ toxicity in Alzheimer's disease.Mitochondrial dysfunction - the beginning of the end in Alzheimer's disease? Separate and synergistic modes of tau and amyloid-β toxicityThe Microtubule-Associated Protein Tau and Its Relevance for Pancreatic Beta Cells.Amylin-Aβ oligomers at atomic resolution using molecular dynamics simulations: a link between Type 2 diabetes and Alzheimer's diseaseAmyloid-β induces hepatic insulin resistance in vivo via JAK2.Degradation of islet amyloid polypeptide by neprilysin.Glucose Dysregulation Interacts With APOE-∊4 to Potentiate Temporoparietal Cortical ThinningLessons from two prevalent amyloidoses-what amylin and Aβ have in commonToxic oligomers and islet beta cell death: guilty by association or convicted by circumstantial evidence?Can stroke cause neurodegenerative dementia?Disease modifying drugs targeting β-amyloid.Amylin and its analogs: a friend or foe for the treatment of Alzheimer's disease?Molecular interaction between type 2 diabetes and Alzheimer's disease through cross-seeding of protein misfolding.NeuroAiD® (MLC601) and amyloid precursor protein processing.New insights into the roles of sulfated glycosaminoglycans in islet amyloid polypeptide amyloidogenesis and cytotoxicity.Mango leaf extract improves central pathology and cognitive impairment in a type 2 diabetes mouse model.Mortality from Alzheimer's disease in Brazil, 2000-2009.Amylin receptor: a common pathophysiological target in Alzheimer's disease and diabetes mellitusβ-Amyloid protein (Aβ) and human amylin regulation of apoptotic genes occurs through the amylin receptor.Inhibition of IAPP aggregation by insulin depends on the insulin oligomeric state regulated by zinc ion concentration.Amyloid-induced β-cell dysfunction and islet inflammation are ameliorated by 4-phenylbutyrate (PBA) treatment.Lipid accelerating the fibril of islet amyloid polypeptide aggravated the pancreatic islet injury in vitro and in vivo.Polymorphic cross-seeding amyloid assemblies of amyloid-β and human islet amyloid polypeptide.
P2860
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P2860
Common features between diabetes mellitus and Alzheimer's disease.
description
article científic
@ca
article scientifique
@fr
articolo scientifico
@it
artigo científico
@pt
bilimsel makale
@tr
scientific article published on April 2009
@en
vedecký článok
@sk
vetenskaplig artikel
@sv
videnskabelig artikel
@da
vědecký článek
@cs
name
Common features between diabetes mellitus and Alzheimer's disease.
@en
Common features between diabetes mellitus and Alzheimer's disease.
@nl
type
label
Common features between diabetes mellitus and Alzheimer's disease.
@en
Common features between diabetes mellitus and Alzheimer's disease.
@nl
prefLabel
Common features between diabetes mellitus and Alzheimer's disease.
@en
Common features between diabetes mellitus and Alzheimer's disease.
@nl
P1476
Common features between diabetes mellitus and Alzheimer's disease.
@en
P2093
P2888
P304
P356
10.1007/S00018-009-9070-1
P577
2009-04-01T00:00:00Z