SAHA enhances Proteostasis of epilepsy-associated α1(A322D)β2γ2 GABA(A) receptors.
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Using pharmacological chaperones to restore proteostasisThe association of the vanin-1 N131S variant with blood pressure is mediated by endoplasmic reticulum-associated degradation and loss of function.The intrinsic and extrinsic effects of N-linked glycans on glycoproteostasis.Combining valosin-containing protein (VCP) inhibition and suberanilohydroxamic acid (SAHA) treatment additively enhances the folding, trafficking, and function of epilepsy-associated γ-aminobutyric acid, type A (GABAA) receptorsGrp94 Protein Delivers γ-Aminobutyric Acid Type A (GABAA) Receptors to Hrd1 Protein-mediated Endoplasmic Reticulum-associated Degradation.Worming our way to novel drug discovery with the Caenorhabditis elegans proteostasis network, stress response and insulin-signaling pathways.Underlying mechanisms and chemical/biochemical therapeutic approaches to ameliorate protein misfolding neurodegenerative diseases.GABA type a receptor trafficking and the architecture of synaptic inhibition.Ethanol Exposure Regulates Gabra1 Expression via Histone Deacetylation at the Promoter in Cultured Cortical Neurons.SAHA (Vorinostat) Corrects Inhibitory Synaptic Deficits Caused by Missense Epilepsy Mutations to the GABAA Receptor γ2 Subunit.Recent neuroimaging, neurophysiological, and neuropathological advances for the understanding of NPC.Tolerance of chronic HDACi treatment for neurological, visceral and lung Niemann-Pick Type C disease in mice.Potential role for histone deacetylation in chronic diazepam-induced downregulation of α1-GABAA receptor subunit expression.
P2860
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P2860
SAHA enhances Proteostasis of epilepsy-associated α1(A322D)β2γ2 GABA(A) receptors.
description
2013 nî lūn-bûn
@nan
2013年の論文
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2013年学术文章
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2013年学术文章
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2013年学术文章
@zh-hans
2013年学术文章
@zh-my
2013年学术文章
@zh-sg
2013年學術文章
@yue
2013年學術文章
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2013年學術文章
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name
SAHA enhances Proteostasis of epilepsy-associated α1
@nl
SAHA enhances Proteostasis of epilepsy-associated α1(A322D)β2γ2 GABA(A) receptors.
@en
type
label
SAHA enhances Proteostasis of epilepsy-associated α1
@nl
SAHA enhances Proteostasis of epilepsy-associated α1(A322D)β2γ2 GABA(A) receptors.
@en
prefLabel
SAHA enhances Proteostasis of epilepsy-associated α1
@nl
SAHA enhances Proteostasis of epilepsy-associated α1(A322D)β2γ2 GABA(A) receptors.
@en
P2093
P2860
P1476
SAHA enhances Proteostasis of epilepsy-associated α1(A322D)β2γ2 GABA(A) receptors
@en
P2093
Dong-Yun Han
Mark R Chance
Xiao-Jing Di
Ya-Juan Wang
P2860
P304
P356
10.1016/J.CHEMBIOL.2013.09.020
P50
P577
2013-11-07T00:00:00Z