Cleavage of the membrane precursor for transforming growth factor alpha is a regulated process.
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A metalloprotease-disintegrin, MDC9/meltrin-gamma/ADAM9 and PKCdelta are involved in TPA-induced ectodomain shedding of membrane-anchored heparin-binding EGF-like growth factor.Gonadotrophin-releasing hormone nerve terminals, tanycytes and neurohaemal junction remodelling in the adult median eminence: functional consequences for reproduction and dynamic role of vascular endothelial cellsDifferential expression and processing of two cell associated forms of the kit-ligand: KL-1 and KL-2Ectodomain shedding of epidermal growth factor receptor ligands is required for keratinocyte migration in cutaneous wound healingEGF signal propagation during C. elegans vulval development mediated by ROM-1 rhomboidModulation of statin-activated shedding of Alzheimer APP ectodomain by ROCKIs neutrophil elastase the missing link between emphysema and fibrosis? Evidence from two mouse models.Constitutive shedding of the amyloid precursor protein ectodomain is up-regulated by tumour necrosis factor-alpha converting enzymeSerotonin 5-HT2a and 5-HT2c receptors stimulate amyloid precursor protein ectodomain secretionPDGF-AA and PDGF-BB biosynthesis: proprotein processing in the Golgi complex and lysosomal degradation of PDGF-BB retained intracellularlyMrna expression of transforming growth factor-alpha and the EGF receptor following nephrotoxic renal injury.Shedding of membrane type 1 matrix metalloproteinase in a human breast carcinoma cell line.The membrane-anchoring domain of epidermal growth factor receptor ligands dictates their ability to operate in juxtacrine modeRole of receptor tyrosine kinases and their ligands in glioblastoma.ADAM10 mediates ectodomain shedding of the betacellulin precursor activated by p-aminophenylmercuric acetate and extracellular calcium influx.Phorbol ester induces the rapid processing of cell surface heparin-binding EGF-like growth factor: conversion from juxtacrine to paracrine growth factor activityGeneration of truncated forms of the NG2 proteoglycan by cell surface proteolysis.Membrane-anchored growth factors, the epidermal growth factor family: beyond receptor ligands.Roles for transforming growth factor-alpha in gastric physiology and pathophysiologyCharacterization of alternative routes for processing of the Alzheimer beta/A4-amyloid precursor protein. Differential effects of phorbol esters and chloroquine.The extracellular regulation of growth factor actionTumor necrosis factor alpha-converting enzyme mediates MUC5AC mucin expression in cultured human airway epithelial cellsADAM proteases, ErbB pathways and cancer.Activated release of membrane-anchored TGF-alpha in the absence of cytosol.Association of the transmembrane TGF-alpha precursor with a protein kinase complex.Apical enrichment of human EGF precursor in Madin-Darby canine kidney cells involves preferential basolateral ectodomain cleavage sensitive to a metalloprotease inhibitorRole of dimerization of the membrane-associated growth factor kit ligand in juxtacrine signaling: the Sl17H mutation affects dimerization and stability-phenotypes in hematopoiesis.Protein phosphorylation regulates secretion of Alzheimer beta/A4 amyloid precursor proteinThe role of protease activity in ErbB biology.Proprotein-processing endoprotease furin controls the growth and differentiation of gastric surface mucous cellsThe carboxyl-terminal valine residues of proTGF alpha are required for its efficient maturation and intracellular routing.Tetraspanins Function as Regulators of Cellular Signaling.GPI-anchored diphtheria toxin receptor allows membrane translocation of the toxin without detectable ion channel activity.Generation of novel, secreted epidermal growth factor receptor (EGFR/ErbB1) isoforms via metalloprotease-dependent ectodomain shedding and exosome secretion.Ectodomain shedding of SHPS-1 and its role in regulation of cell migration.Regulated cell surface pro-EGF ectodomain shedding is a zinc metalloprotease-dependent process.Impaired trafficking and activation of tumor necrosis factor-alpha-converting enzyme in cell mutants defective in protein ectodomain shedding.Characterization of growth factor-induced serine phosphorylation of tumor necrosis factor-alpha converting enzyme and of an alternatively translated polypeptide.Neutrophil elastase induces mucin production by ligand-dependent epidermal growth factor receptor activation.Mitogen-activated protein kinase-dependent and -independent routes control shedding of transmembrane growth factors through multiple secretases.
P2860
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P2860
Cleavage of the membrane precursor for transforming growth factor alpha is a regulated process.
description
article científic
@ca
article scientifique
@fr
articolo scientifico
@it
artigo científico
@pt
bilimsel makale
@tr
scientific article published on March 1991
@en
vedecký článok
@sk
vetenskaplig artikel
@sv
videnskabelig artikel
@da
vědecký článek
@cs
name
Cleavage of the membrane precu ...... alpha is a regulated process.
@en
Cleavage of the membrane precu ...... alpha is a regulated process.
@nl
type
label
Cleavage of the membrane precu ...... alpha is a regulated process.
@en
Cleavage of the membrane precu ...... alpha is a regulated process.
@nl
prefLabel
Cleavage of the membrane precu ...... alpha is a regulated process.
@en
Cleavage of the membrane precu ...... alpha is a regulated process.
@nl
P2860
P356
P1476
Cleavage of the membrane precu ...... alpha is a regulated process.
@en
P2093
Massagué J
Pandiella A
P2860
P304
P356
10.1073/PNAS.88.5.1726
P407
P577
1991-03-01T00:00:00Z