Analogues of 2-aminopyridine-based selective inhibitors of neuronal nitric oxide synthase with increased bioavailability
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Role of zinc in isoform-selective inhibitor binding to neuronal nitric oxide synthaseStructure-based design, synthesis, and biological evaluation of lipophilic-tailed monocationic inhibitors of neuronal nitric oxide synthasePeripheral but crucial: A hydrophobic pocket (Tyr706, Leu337, and Met336) for potent and selective inhibition of neuronal nitric oxide synthasePotent, Highly Selective, and Orally Bioavailable Gem -Difluorinated Monocationic Inhibitors of Neuronal Nitric Oxide SynthaseExploration of the Active Site of Neuronal Nitric Oxide Synthase by the Design and Synthesis of Pyrrolidinomethyl 2-Aminopyridine DerivativesImproved Synthesis of Chiral Pyrrolidine Inhibitors and Their Binding Properties to Neuronal Nitric Oxide SynthaseCyclopropyl- and methyl-containing inhibitors of neuronal nitric oxide synthaseIntramolecular hydrogen bonding: A potential strategy for more bioavailable inhibitors of neuronal nitric oxide synthaseSelective Monocationic Inhibitors of Neuronal Nitric Oxide Synthase. Binding Mode Insights from Molecular Dynamics SimulationsSimplified 2-Aminoquinoline-Based Scaffold for Potent and Selective Neuronal Nitric Oxide Synthase InhibitionPotent and selective neuronal nitric oxide synthase inhibitors with improved cellular permeability.An Alkoxide Anion Triggered tert-Butyloxycarbonyl Group Migration. Mechanism and Application.Development of nitric oxide synthase inhibitors for neurodegeneration and neuropathic pain.Arylsulfanyl pyrazolones block mutant SOD1-G93A aggregation. Potential application for the treatment of amyotrophic lateral sclerosisSymmetric double-headed aminopyridines, a novel strategy for potent and membrane-permeable inhibitors of neuronal nitric oxide synthaseAcid-Facilitated Debenzylation of N-Boc, N-Benzyl Double Protected 2-Aminopyridinomethylpyrrolidine DerivativesOn the selectivity of neuronal NOS inhibitorsL337H mutant of rat neuronal nitric oxide synthase resembles human neuronal nitric oxide synthase toward inhibitors.Effect of potential amine prodrugs of selective neuronal nitric oxide synthase inhibitors on blood-brain barrier penetration.Concise route to the chiral pyrrolidine core of selective inhibitors of neuronal nitric oxide.Novel nitric oxide synthase inhibitors: a patent review.Structural basis for isoform-selective inhibition in nitric oxide synthase.Synthesis of a Potent Aminopyridine-Based nNOS-Inhibitor by Two Recent No-Carrier-Added (18)F-Labelling Methods.
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P2860
Analogues of 2-aminopyridine-based selective inhibitors of neuronal nitric oxide synthase with increased bioavailability
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article científic
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article scientifique
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articolo scientifico
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artigo científico
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bilimsel makale
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scientific article published on 14 February 2009
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vedecký článok
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vetenskaplig artikel
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videnskabelig artikel
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vědecký článek
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name
Analogues of 2-aminopyridine-b ...... with increased bioavailability
@en
Analogues of 2-aminopyridine-b ...... ith increased bioavailability.
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type
label
Analogues of 2-aminopyridine-b ...... with increased bioavailability
@en
Analogues of 2-aminopyridine-b ...... ith increased bioavailability.
@nl
prefLabel
Analogues of 2-aminopyridine-b ...... with increased bioavailability
@en
Analogues of 2-aminopyridine-b ...... ith increased bioavailability.
@nl
P2093
P2860
P1476
Analogues of 2-aminopyridine-b ...... with increased bioavailability
@en
P2093
D Martin Watterson
Fengtian Xue
Graham R Lawton
Hantamalala Ralay Ranaivo
Laura K Chico
Linda J Roman
Pavel Martásek
Richard B Silverman
P2860
P304
P356
10.1016/J.BMC.2009.02.017
P407
P577
2009-02-14T00:00:00Z