Cofactor binding and enzymatic activity in an unevolved superfamily of de novo designed 4-helix bundle proteins.
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Protein design: toward functional metalloenzymesDesign of a switchable eliminaseComparison of the frequency of functional SH3 domains with different limited sets of amino acids using mRNA display.On the role of physics and evolution in dictating protein structure and functionAmino acid alphabet reduction preserves fold information contained in contact interactions in proteins.The Rodin-Ohno hypothesis that two enzyme superfamilies descended from one ancestral gene: an unlikely scenario for the origins of translation that will not be dismissed.Comparative characterization of random-sequence proteins consisting of 5, 12, and 20 kinds of amino acids.Expression, purification, and characterization of proteins from high-quality combinatorial libraries of the mammalian calmodulin central linkerDe novo designed proteins from a library of artificial sequences function in Escherichia coli and enable cell growthDirected evolution of the peroxidase activity of a de novo-designed protein.Histidyl-tRNA synthetase urzymes: Class I and II aminoacyl tRNA synthetase urzymes have comparable catalytic activities for cognate amino acid activation.Proteins from an unevolved library of de novo designed sequences bind a range of small molecules.Interplay of physics and evolution in the likely origin of protein biochemical functionDivergent evolution of a bifunctional de novo proteinEvolution of new functions de novo and from preexisting genes.De Novo Proteins with Life-Sustaining Functions Are Structurally DynamicA de novo protein confers copper resistance in Escherichia coli.A protein constructed de novo enables cell growth by altering gene regulation.Computational strategies for the design of new enzymatic functionsFast, cheap and out of control--Insights into thermodynamic and informatic constraints on natural protein sequences from de novo protein design.Statistical evaluation of the Rodin-Ohno hypothesis: sense/antisense coding of ancestral class I and II aminoacyl-tRNA synthetases.Aminoacylating urzymes challenge the RNA world hypothesisShort peptides self-assemble to produce catalytic amyloids.Constructing manmade enzymes for oxygen activation.Flexibility and reactivity in promiscuous enzymes.Rational heme protein design: all roads lead to Rome.Synthetic biology for the directed evolution of protein biocatalysts: navigating sequence space intelligently.On primordial sense-antisense coding.Machine learning of single molecule free energy surfaces and the impact of chemistry and environment upon structure and dynamics.Interdependence, Reflexivity, Fidelity, Impedance Matching, and the Evolution of Genetic Coding.Hierarchical design of artificial proteins and complexes toward synthetic structural biology.Coding of Class I and II Aminoacyl-tRNA Synthetases.Design of a heme-binding peptide motif adopting a β-hairpin conformation.The de novo design of a biocompatible and functional integral membrane protein using minimal sequence complexity
P2860
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P2860
Cofactor binding and enzymatic activity in an unevolved superfamily of de novo designed 4-helix bundle proteins.
description
article científic
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article scientifique
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articolo scientifico
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artigo científico
@pt
bilimsel makale
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scientific article published on July 2009
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vedecký článok
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vetenskaplig artikel
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videnskabelig artikel
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vědecký článek
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name
Cofactor binding and enzymatic ...... igned 4-helix bundle proteins.
@en
Cofactor binding and enzymatic ...... igned 4-helix bundle proteins.
@nl
type
label
Cofactor binding and enzymatic ...... igned 4-helix bundle proteins.
@en
Cofactor binding and enzymatic ...... igned 4-helix bundle proteins.
@nl
prefLabel
Cofactor binding and enzymatic ...... igned 4-helix bundle proteins.
@en
Cofactor binding and enzymatic ...... igned 4-helix bundle proteins.
@nl
P2093
P2860
P356
P1433
P1476
Cofactor binding and enzymatic ...... igned 4-helix bundle proteins.
@en
P2093
Luke H Bradley
Michael H Hecht
Sayuri P Jinadasa
Shona C Patel
P2860
P304
P356
10.1002/PRO.147
P577
2009-07-01T00:00:00Z