Mechanisms of biphasic insulin-granule exocytosis - roles of the cytoskeleton, small GTPases and SNARE proteins.
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Synapses of amphids defective (SAD-A) kinase promotes glucose-stimulated insulin secretion through activation of p21-activated kinase (PAK1) in pancreatic β-CellsRegulation of intracellular membrane trafficking and cell dynamics by syntaxin-6Paracrine and autocrine interactions in the human islet: more than meets the eyeGLP-1 receptor activated insulin secretion from pancreatic β-cells: mechanism and glucose dependenceRho GTPases, phosphoinositides, and actin: a tripartite framework for efficient vesicular traffickingCyclic AMP dynamics in the pancreatic β-cellPhosphoinositides: tiny lipids with giant impact on cell regulationSignaling mechanisms of glucose-induced F-actin remodeling in pancreatic islet β cellsMicrotubules Negatively Regulate Insulin Secretion in Pancreatic β Cells.Cytoskeletal dependence of insulin granule movement dynamics in INS-1 beta-cells in response to glucosePreferential release of newly synthesized insulin assessed by a multi-label reporter system using pancreatic β-cell line MIN6Computational analysis of Rho GTPase cyclingPositional cloning of a type 2 diabetes quantitative trait locus; tomosyn-2, a negative regulator of insulin secretionInsulin biosynthetic interaction network component, TMEM24, facilitates insulin reserve pool releaseCool-1/βPIX functions as a guanine nucleotide exchange factor in the cycling of Cdc42 to regulate insulin secretionPancreatic β-cell Raf-1 is required for glucose tolerance, insulin secretion, and insulin 2 transcriptionDiscovery of novel vitamin D-regulated proteins in INS-1 cells: a proteomic approachArgonaute2 mediates compensatory expansion of the pancreatic β cell.An intracellular role for ABCG1-mediated cholesterol transport in the regulated secretory pathway of mouse pancreatic beta cells.Cholesterol regulates glucose-stimulated insulin secretion through phosphatidylinositol 4,5-bisphosphate.Intracellular transport of insulin granules is a subordinated random walk.Gene targeting implicates Cdc42 GTPase in GPVI and non-GPVI mediated platelet filopodia formation, secretion and aggregation.Combined lipidomic and proteomic analysis of isolated human islets exposed to palmitate reveals time-dependent changes in insulin secretion and lipid metabolismGlucose activates prenyltransferases in pancreatic islet beta-cells.Gαo represses insulin secretion by reducing vesicular docking in pancreatic beta-cells.Mitochondrial metabolism of pyruvate is essential for regulating glucose-stimulated insulin secretionProtein farnesylation-dependent Raf/extracellular signal-related kinase signaling links to cytoskeletal remodeling to facilitate glucose-induced insulin secretion in pancreatic beta-cells.Small G proteins in islet beta-cell function.Inhibitory G proteins and their receptors: emerging therapeutic targets for obesity and diabetes.Obesity and genetics regulate microRNAs in islets, liver, and adipose of diabetic mice.Regulation of insulin secretion: role of mitochondrial signalling.Regulation of retinoschisin secretion in Weri-Rb1 cells by the F-actin and microtubule cytoskeleton.Cell signalling in insulin secretion: the molecular targets of ATP, cAMP and sulfonylurea.High glucose predisposes gene expression and ERK phosphorylation to apoptosis and impaired glucose-stimulated insulin secretion via the cytoskeletonInsulin secretion induced by glucose-dependent insulinotropic polypeptide requires phosphatidylinositol 3-kinase γ in rodent and human β-cells.The syntaxin 4 N terminus regulates its basolateral targeting by munc18c-dependent and -independent mechanismsSyntaxin 1A regulates surface expression of beta-cell ATP-sensitive potassium channels.Phagocyte-like NADPH oxidase generates ROS in INS 832/13 cells and rat islets: role of protein prenylation.Friendly, and not so friendly, roles of Rac1 in islet β-cell function: lessons learnt from pharmacological and molecular biological approachesArf nucleotide binding site opener [ARNO] promotes sequential activation of Arf6, Cdc42 and Rac1 and insulin secretion in INS 832/13 β-cells and rat islets.
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P2860
Mechanisms of biphasic insulin-granule exocytosis - roles of the cytoskeleton, small GTPases and SNARE proteins.
description
article científic
@ca
article scientifique
@fr
articolo scientifico
@it
artigo científico
@pt
bilimsel makale
@tr
scientific article published on April 2009
@en
vedecký článok
@sk
vetenskaplig artikel
@sv
videnskabelig artikel
@da
vědecký článek
@cs
name
Mechanisms of biphasic insulin ...... ll GTPases and SNARE proteins.
@en
Mechanisms of biphasic insulin ...... ll GTPases and SNARE proteins.
@nl
type
label
Mechanisms of biphasic insulin ...... ll GTPases and SNARE proteins.
@en
Mechanisms of biphasic insulin ...... ll GTPases and SNARE proteins.
@nl
prefLabel
Mechanisms of biphasic insulin ...... ll GTPases and SNARE proteins.
@en
Mechanisms of biphasic insulin ...... ll GTPases and SNARE proteins.
@nl
P2860
P921
P356
P1476
Mechanisms of biphasic insulin ...... ll GTPases and SNARE proteins.
@en
P2093
Debbie C Thurmond
Zhanxiang Wang
P2860
P304
P356
10.1242/JCS.034355
P407
P577
2009-04-01T00:00:00Z