Synergistic effect of aptamers that inhibit exosites 1 and 2 on thrombin.
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Crystal structure of an RNA aptamer bound to thrombinModulation of the Coagulation Cascade Using AptamersProbing the coagulation pathway with aptamers identifies combinations that synergistically inhibit blood clot formation.Artificial specific binders directly recovered from chemically modified nucleic acid libraries.New Technologies Provide Quantum Changes in the Scale, Speed, and Success of SELEX Methods and Aptamer Characterization.On the specificity of heparin/heparan sulfate binding to proteins. Anion-binding sites on antithrombin and thrombin are fundamentally different.Discovery of allosteric modulators of factor XIa by targeting hydrophobic domains adjacent to its heparin-binding site.Array-based discovery of aptamer pairsPotent anticoagulant aptamer directed against factor IXa blocks macromolecular substrate interaction.Targeting Two Coagulation Cascade Proteases with a Bivalent Aptamer Yields a Potent and Antidote-Controllable Anticoagulant.Translation and Clinical Development of Antithrombotic Aptamers.Role of electrostatic interactions in binding of thrombin to the fibrinogen γ' chain.Through-bond effects in the ternary complexes of thrombin sandwiched by two DNA aptamers.Aptamers as targeted therapeutics: current potential and challenges.A high affinity, antidote-controllable prothrombin and thrombin-binding RNA aptamer inhibits thrombin generation and thrombin activity.Highly efficient control of thrombin activity by multivalent nanoparticles.Specific Light-Up System for Protein and Metabolite Targets Triggered by Initiation Complex Formation.A small group of sulfated benzofurans induces steady-state submaximal inhibition of thrombin.Molecular dynamics simulations of aptamer-binding reveal generalized allostery in thrombin.Aptamer-guided caging for selective masking of protein domains.Molecular Modeling Applied to Nucleic Acid-Based Molecule Development
P2860
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P2860
Synergistic effect of aptamers that inhibit exosites 1 and 2 on thrombin.
description
article científic
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article scientifique
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articolo scientifico
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artigo científico
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bilimsel makale
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scientific article published on 21 October 2009
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vedecký článok
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vetenskaplig artikel
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videnskabelig artikel
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vědecký článek
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name
Synergistic effect of aptamers that inhibit exosites 1 and 2 on thrombin.
@en
Synergistic effect of aptamers that inhibit exosites 1 and 2 on thrombin.
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type
label
Synergistic effect of aptamers that inhibit exosites 1 and 2 on thrombin.
@en
Synergistic effect of aptamers that inhibit exosites 1 and 2 on thrombin.
@nl
prefLabel
Synergistic effect of aptamers that inhibit exosites 1 and 2 on thrombin.
@en
Synergistic effect of aptamers that inhibit exosites 1 and 2 on thrombin.
@nl
P2093
P2860
P356
P1433
P1476
Synergistic effect of aptamers that inhibit exosites 1 and 2 on thrombin
@en
P2093
Bruce A Sullenger
Kristin M Bompiani
Sabah Oney
Shahid M Nimjee
Steve B Long
Zoya Volovyk
P2860
P304
P356
10.1261/RNA.1240109
P407
P577
2009-10-21T00:00:00Z