Pharmacological inhibition of integrin alphavbeta3 aggravates experimental liver fibrosis and suppresses hepatic angiogenesis. - Wikidata - wikimedia - TriplyDB

Pharmacological inhibition of integrin alphavbeta3 aggravates experimental liver fibrosis and suppresses hepatic angiogenesis.

Pharmacological inhibition of integrin alphavbeta3 aggravates experimental liver fibrosis and suppresses hepatic angiogenesis.

http://www.wikidata.org/entity/Q37426714

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Mechanisms of adaptation of the hepatic vasculature to the deteriorating conditions of blood circulation in liver cirrhosis αv integrins: key regulators of tissue fibrosis Prevention of liver fibrosis by intrasplenic injection of high-density cultured bone marrow cells in a rat chronic liver injury model Molecular magnetic resonance imaging of activated hepatic stellate cells with ultrasmall superparamagnetic iron oxide targeting integrin αvβ₃ for staging liver fibrosis in rat model.Complementary vascular and matrix regulatory pathways underlie the beneficial mechanism of action of sorafenib in liver fibrosis.Aquaporin-1 facilitates angiogenic invasion in the pathological neovasculature that accompanies cirrhosis Evolving therapies for liver fibrosis.Integrins αvβ5 and αvβ3 promote latent TGF-β1 activation by human cardiac fibroblast contraction Adenosine 5'-monophosphate ameliorates D-galactosamine/lipopolysaccharide-induced liver injury through an adenosine receptor-independent mechanism in mice.Hydrogels with differential and patterned mechanics to study stiffness-mediated myofibroblastic differentiation of hepatic stellate cells.Loss of myeloid cell-derived vascular endothelial growth factor accelerates fibrosis Aquaporin-1 promotes angiogenesis, fibrosis, and portal hypertension through mechanisms dependent on osmotically sensitive microRNAs Future therapy of portal hypertension in liver cirrhosis - a guess.Fibrinogen deficiency increases liver injury and early growth response-1 (Egr-1) expression in a model of chronic xenobiotic-induced cholestasis.Celecoxib ameliorates portal hypertension of the cirrhotic rats through the dual inhibitory effects on the intrahepatic fibrosis and angiogenesis Novel therapeutic strategies for targeting liver cancer stem cells.Vitronectin accumulates in the interstitium but minimally impacts fibrogenesis in experimental chronic kidney disease Obesity, diabetes mellitus, and liver fibrosis.Protective Effects of Norursodeoxycholic Acid Versus Ursodeoxycholic Acid on Thioacetamide-induced Rat Liver Fibrosis Involvement of cholangiocyte proliferation in biliary fibrosis.Combination of sorafenib and gadolinium chloride (GdCl3) attenuates dimethylnitrosamine(DMN)-induced liver fibrosis in rats Cannabinoid receptor type I modulates alcohol-induced liver fibrosis.Specific hepatic delivery of procollagen α1(I) small interfering RNA in lipid-like nanoparticles resolves liver fibrosis Osteopontin, an oxidant stress sensitive cytokine, up-regulates collagen-I via integrin α(V)β(3) engagement and PI3K/pAkt/NFκB signaling.Hepatic macrophages in liver fibrosis: pathogenesis and potential therapeutic targets.Microvascular targets for anti-fibrotic therapeutics Targeting of αv integrin identifies a core molecular pathway that regulates fibrosis in several organs.αvβ1 integrin as a novel therapeutic target for tissue fibrosis.Increased activation of latent TGF-β1 by αVβ3 in human Crohn's disease and fibrosis in TNBS colitis can be prevented by cilengitide.Reduction of hepatic fibrosis by overexpression of von Hippel-Lindau protein in experimental models of chronic liver disease Vascular factors, angiogenesis and biliary tract disease Role of integrins in fibrosing liver diseases.Integrin-mediated regulation of TGFβ in fibrosis Antifibrotic therapies in the liver.Angiogenesis in liver regeneration and fibrosis: "a double-edged sword".Integrins and integrin-related proteins in cardiac fibrosis.Thyroid Hormone, Hormone Analogs, and Angiogenesis.Detrimental effects of nicotine on thioacetamide-induced liver injury in mice.Portal myofibroblasts connect angiogenesis and fibrosis in liver.Spike-in SILAC proteomic approach reveals the vitronectin as an early molecular signature of liver fibrosis in hepatitis C infections with hepatic iron overload.

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Pharmacological inhibition of integrin alphavbeta3 aggravates experimental liver fibrosis and suppresses hepatic angiogenesis.

http://www.wikidata.org/entity/Q37426714

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Felix Stickel

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P2860

Nanomolar small molecule inhibitors for alphav(beta)6, alphav(beta)5, and alphav(beta)3 integrins

Hypoxia-induced VEGF and collagen I expressions are associated with angiogenesis and fibrogenesis in experimental cirrhosis

Mechanisms of hepatic fibrogenesis

Biological and molecular properties of a new alpha(v)beta3/alpha(v)beta5 integrin antagonist.

A novel, simple method of functional spleen volume calculation by liver-spleen scan.

Selective depletion of macrophages reveals distinct, opposing roles during liver injury and repair.

Liver cirrhosis

Matrix as a modulator of hepatic fibrogenesis.

Leptin-mediated neovascularization is a prerequisite for progression of nonalcoholic steatohepatitis in rats.

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