Interleukin 12 stimulates IFN-gamma-mediated inhibition of tumor-induced regulatory T-cell proliferation and enhances tumor clearance
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CD16+ monocytes control T-cell subset development in immune thrombocytopenia.Immunotherapy with IL-10- and IFN-γ-producing CD4 effector cells modulate "Natural" and "Inducible" CD4 TReg cell subpopulation levels: observations in four cases of patients with ovarian cancer.Tumor-targeted T cells modified to secrete IL-12 eradicate systemic tumors without need for prior conditioning.Interleukin 12 shows a better curative effect on lung cancer than paclitaxel and cisplatin doublet chemotherapy.Expanding roles for CD4 T cells and their subpopulations in tumor immunity and therapy.Depleting tumor-specific Tregs at a single site eradicates disseminated tumors.Oncolytic adenovirus expressing IL-23 and p35 elicits IFN-γ- and TNF-α-co-producing T cell-mediated antitumor immunity.Multifaceted oncolytic virus therapy for glioblastoma in an immunocompetent cancer stem cell model.Interferon-Gamma Receptor Signaling Plays an Important Role in Restraining Murine Ovarian Tumor Progression.Dual biological effects of the cytokines interleukin-10 and interferon-γ.Authentic GITR Signaling Fails To Induce Tumor Regression unless Foxp3+ Regulatory T Cells Are Depleted.The multikinase inhibitor sorafenib reverses the suppression of IL-12 and enhancement of IL-10 by PGE₂ in murine macrophages.Granzyme B Contributes to the Optimal Graft-Versus-Tumor Effect Mediated by Conventional CD4+ T Cells.Sendai viroplexes for epidermal growth factor receptor-directed delivery of interleukin-12 and salmosin genes to cancer cells.Systemic inflammatory response elicited by superantigen destabilizes T regulatory cells, rendering them ineffective during toxic shock syndromeIntratumoural interleukin 12 gene therapy stimulates the immune system and decreases angiogenesis in dogs with spontaneous cancer.Dendritic cell activation enhances anti-PD-1 mediated immunotherapy against glioblastoma.
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P2860
Interleukin 12 stimulates IFN-gamma-mediated inhibition of tumor-induced regulatory T-cell proliferation and enhances tumor clearance
description
article científic
@ca
article scientifique
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articolo scientifico
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artigo científico
@pt
bilimsel makale
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scientific article published on 20 October 2009
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vedecký článok
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vetenskaplig artikel
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videnskabelig artikel
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vědecký článek
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name
Interleukin 12 stimulates IFN- ...... n and enhances tumor clearance
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Interleukin 12 stimulates IFN- ...... and enhances tumor clearance.
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type
label
Interleukin 12 stimulates IFN- ...... n and enhances tumor clearance
@en
Interleukin 12 stimulates IFN- ...... and enhances tumor clearance.
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Interleukin 12 stimulates IFN- ...... n and enhances tumor clearance
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Interleukin 12 stimulates IFN- ...... and enhances tumor clearance.
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Interleukin 12 stimulates IFN- ...... n and enhances tumor clearance
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P2093
David Piwnica-Worms
Jacqueline E Payton
Joshua C Mayer
Karen Leonard
Lynne I Collins
Michael J Walter
Robert D Schreiber
Timothy J Ley
Xuefang Cao
P2860
P304
P356
10.1158/0008-5472.CAN-09-1145
P407
P50
P577
2009-10-20T00:00:00Z