A novel DNMT3B splice variant expressed in tumor and pluripotent cells modulates genomic DNA methylation patterns and displays altered DNA binding.
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Downregulation of HTPAP transcript variant 1 correlates with tumor metastasis and poor survival in patients with hepatocellular carcinomaDnmt3b Prefers Germ Line Genes and Centromeric Regions: Lessons from the ICF Syndrome and Cancer and Implications for DiseasesA concise review on epigenetic regulation: insight into molecular mechanismsInactive DNMT3B splice variants modulate de novo DNA methylationModulation of Dnmt3b function in vitro by interactions with Dnmt3L, Dnmt3a and Dnmt3b splice variantsTF-Cluster: a pipeline for identifying functionally coordinated transcription factors via network decomposition of the shared coexpression connectivity matrix (SCCM)Dnmt3b recruitment through E2F6 transcriptional repressor mediates germ-line gene silencing in murine somatic tissuesA DNMT3B alternatively spliced exon and encoded peptide are novel biomarkers of human pluripotent stem cellsDNMT3B7, a truncated DNMT3B isoform expressed in human tumors, disrupts embryonic development and accelerates lymphomagenesis.Genome-wide profiling of pluripotent cells reveals a unique molecular signature of human embryonic germ cells.RNA-binding proteins in pluripotency, differentiation, and reprogramming.Coordinated cancer germline antigen promoter and global DNA hypomethylation in ovarian cancer: association with the BORIS/CTCF expression ratio and advanced stageRegulation of pluripotency by RNA binding proteinsDNA Methylation Modulates Nociceptive Sensitization after Incision.Association of DNMT3B -283 T > C and -579 G > T polymorphisms with decreased cancer risk: evidence from a meta-analysis.Diurnal expression of Dnmt3b mRNA in mouse liver is regulated by feeding and hepatic clockwork.DNMT3B isoforms without catalytic activity stimulate gene body methylation as accessory proteins in somatic cellsRegulation of CpG methylation by Dnmt and Tet in pluripotent stem cells.Generation of an ICF syndrome model by efficient genome editing of human induced pluripotent stem cells using the CRISPR system.DNA Methylation Targeting: The DNMT/HMT Crosstalk Challenge.An association between overexpression of DNA methyltransferase 3B4 and clear cell renal cell carcinoma.Promises and challenges of anticancer drugs that target the epigenome.The Mechanism and Function of Epigenetics in Uterine Leiomyoma Development.DNMT3b Modulates Melanoma Growth by Controlling Levels of mTORC2 Component RICTOR.Splice variants DNMT3B4 and DNMT3B7 overexpression inhibit cell proliferation in 293A cell line.DNA methylation aberrancies as a guide for surveillance and treatment of human cancers.A shRNA functional screen reveals Nme6 and Nme7 are crucial for embryonic stem cell renewal.Genome-wide methylation analysis of DNMT3B gene isoforms revealed specific methylation profiles in breast cell lines.DNMT3B gene amplification predicts resistance to DNA demethylating drugs.Epimutations mimic genomic mutations of DNMT3A in acute myeloid leukemia.Expression of DNA methyltransferases in adult dorsal root ganglia is cell-type specific and up regulated in a rodent model of neuropathic pain.Dnmt3a and Dnmt3b have overlapping and distinct functions in hematopoietic stem cells.Isoform-specific localization of DNMT3A regulates DNA methylation fidelity at bivalent CpG islands.Identification of a novel leukemic-specific splice variant of DNMT3B and its stability.DNMT3B Functions: Novel Insights From Human Disease
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P2860
A novel DNMT3B splice variant expressed in tumor and pluripotent cells modulates genomic DNA methylation patterns and displays altered DNA binding.
description
article científic
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article scientifique
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articolo scientifico
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artigo científico
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bilimsel makale
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scientific article published on 13 October 2009
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vedecký článok
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vetenskaplig artikel
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videnskabelig artikel
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vědecký článek
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name
A novel DNMT3B splice variant ...... displays altered DNA binding.
@en
A novel DNMT3B splice variant ...... displays altered DNA binding.
@nl
type
label
A novel DNMT3B splice variant ...... displays altered DNA binding.
@en
A novel DNMT3B splice variant ...... displays altered DNA binding.
@nl
prefLabel
A novel DNMT3B splice variant ...... displays altered DNA binding.
@en
A novel DNMT3B splice variant ...... displays altered DNA binding.
@nl
P2093
P2860
P1476
A novel DNMT3B splice variant ...... d displays altered DNA binding
@en
P2093
Beth O Van Emburgh
C Robert Fields
Jixiu Shan
Johannes Vieweg
Naohiro Terada
Philip H Schwartz
Suhasni Gopalakrishnan
Takashi Hamazaki
P2860
P304
P356
10.1158/1541-7786.MCR-09-0018
P577
2009-10-13T00:00:00Z