Role of cytochrome P450 2E1 in protein nitration and ubiquitin-mediated degradation during acetaminophen toxicity. - Wikidata - wikimedia - TriplyDB

Role of cytochrome P450 2E1 in protein nitration and ubiquitin-mediated degradation during acetaminophen toxicity.

Role of cytochrome P450 2E1 in protein nitration and ubiquitin-mediated degradation during acetaminophen toxicity.

http://www.wikidata.org/entity/Q37442120

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Mitochondrial dysfunction and tissue injury by alcohol, high fat, nonalcoholic substances and pathological conditions through post-translational protein modifications Functional roles of protein nitration in acute and chronic liver diseases Identification of novel translational urinary biomarkers for acetaminophen-induced acute liver injury using proteomic profiling in mice Lack of PPARα exacerbates lipopolysaccharide-induced liver toxicity through STAT1 inflammatory signaling and increased oxidative/nitrosative stress PPARalpha expression protects male mice from high fat-induced nonalcoholic fatty liver.Proteomic profiling in incubation medium of mouse, rat and human precision-cut liver slices for biomarker detection regarding acute drug-induced liver injury.Post-translational modifications of mitochondrial aldehyde dehydrogenase and biomedical implications.Aminotriazole alleviates acetaminophen poisoning via downregulating P450 2E1 and suppressing inflammation Acetaminophen-induced hepatotoxicity and protein nitration in neuronal nitric-oxide synthase knockout mice Increased oxidative-modifications of cytosolic proteins in 3,4-methylenedioxymethamphetamine (MDMA, ecstasy)-exposed rat liver.Additive effects of mitochondrion-targeted cytochrome CYP2E1 and alcohol toxicity on cytochrome c oxidase function and stability of respirosome complexes.Nitric oxide in liver diseases.Critical role of cytochrome P450 2E1 (CYP2E1) in the development of high fat-induced non-alcoholic steatohepatitis.Coexistence of hyperlipidemia and acute cerebral ischemia/reperfusion induces severe liver damage in a rat model.Protection against acetaminophen-induced acute liver failure by omentum adipose tissue derived stem cells through the mediation of Nrf2 and cytochrome P450 expression Role of CYP2E1 in mitochondrial dysfunction and hepatic tissue injury in alcoholic and non-alcoholic diseases.Cytochrome P450-2E1 promotes aging-related hepatic steatosis, apoptosis and fibrosis through increased nitroxidative stress.Mitochondrial dysfunction and cell death in neurodegenerative diseases through nitroxidative stress Increased nitroxidative stress promotes mitochondrial dysfunction in alcoholic and nonalcoholic fatty liver disease.Robust protein nitration contributes to acetaminophen-induced mitochondrial dysfunction and acute liver injury Hepatoprotective Effect of Opuntia robusta and Opuntia streptacantha Fruits against Acetaminophen-Induced Acute Liver Damage A novel upregulation of glutathione peroxidase 1 by knockout of liver-regenerating protein Reg3β aggravates acetaminophen-induced hepatic protein nitration.CYP2E1 potentiates binge alcohol-induced gut leakiness, steatohepatitis, and apoptosis.Targeting nitrative stress for attenuating cisplatin-induced downregulation of cochlear LIM domain only 4 and ototoxicity Effects of acetaminophen on mitochondrial complex I activity in the rat liver and kidney: a PET study with 18F-BCPP-BF.Immature mice are more susceptible than adult mice to acetaminophen-induced acute liver injury Application of urine proteomics for biomarker discovery in drug-induced liver injury.The Contribution of Singlet Oxygen to Insulin Resistance.Quantitative analysis of acetaminophen and its primary metabolites in small plasma volumes by liquid chromatography-tandem mass spectrometry.Antioxidant and Hepatoprotective Efficiency of Selenium Nanoparticles Against Acetaminophen-Induced Hepatic Damage.Preventive effects of dietary walnuts on high-fat-induced hepatic fat accumulation, oxidative stress and apoptosis in mice.Proteomic analysis of acetaminophen-induced hepatotoxicity and identification of heme oxygenase 1 as a potential plasma biomarker of liver injury.Cytochrome P450-2E1 is involved in aging-related kidney damage in mice through increased nitroxidative stress.Apoptosis of enterocytes and nitration of junctional complex proteins promote alcohol-induced gut leakiness and liver injury.Korean red ginseng extract prevents APAP-induced hepatotoxicity through metabolic enzyme regulation: the role of ginsenoside Rg3, a protopanaxadiol.Exogenous exosomes from mice with acetaminophen-induced liver injury promote toxicity in the recipient hepatocytes and mice

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Role of cytochrome P450 2E1 in protein nitration and ubiquitin-mediated degradation during acetaminophen toxicity.

http://www.wikidata.org/entity/Q37442120

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scientific article published on 04 August 2009

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J.BCP.2009.07.016

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Biochemical Pharmacology

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Role of cytochrome P450 2E1 in ...... during acetaminophen toxicity.

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Byoung-Joon Song

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Chi Chen

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Frank J Gonzalez

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Kwan-Hoon Moon

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Mohamed A Abdelmegeed

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P2860

Nitric oxide and peroxynitrite in health and disease

Acetaminophen-induced hepatotoxicity

Oxidative chemistry of nitric oxide: the roles of superoxide, peroxynitrite, and carbon dioxide

The ubiquitin-proteasome proteolytic pathway

Selective protein arylation and acetaminophen-induced hepatotoxicity.

Evidence that light modulates protein nitration in rat retina.

Identification of the hepatic protein targets of reactive metabolites of acetaminophen in vivo in mice using two-dimensional gel electrophoresis and mass spectrometry.

Increased oxidation and degradation of cytosolic proteins in alcohol-exposed mouse liver and hepatoma cells.

Results of a prospective study of acute liver failure at 17 tertiary care centers in the United States.

Evidence that acetaminophen and N-hydroxyacetaminophen form a common arylating intermediate, N-acetyl-p-benzoquinoneimine.

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