When the sphingosine kinase 1/sphingosine 1-phosphate pathway meets hypoxia signaling: new targets for cancer therapy.
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Discovery, synthesis and SAR analysis of novel selective small molecule S1P4-R agonists based on a (2Z,5Z)-5-((pyrrol-3-yl)methylene)-3-alkyl-2-(alkylimino)thiazolidin-4-one chemotypeMouse Sphingosine Kinase 1a Is Negatively Regulated through Conventional PKC-Dependent Phosphorylation at S373 ResidueHypoxic preconditioning induces stroke tolerance in mice via a cascading HIF, sphingosine kinase, and CCL2 signaling pathwaySphingosine kinase type 1 inhibition reveals rapid turnover of circulating sphingosine 1-phosphate.Sphingosine-1-phosphate as an amphipathic metabolite: its properties in aqueous and membrane environmentsNovel pathways for implantation and establishment and maintenance of pregnancy in mammals.S1P metabolism in cancer and other pathological conditions.Sphingosine kinase 1 regulates the Akt/FOXO3a/Bim pathway and contributes to apoptosis resistance in glioma cells.Sphingosine-1-phosphate antibodies as potential agents in the treatment of cancer and age-related macular degenerationTumor-suppressive sphingosine-1-phosphate receptor-2 counteracting tumor-promoting sphingosine-1-phosphate receptor-1 and sphingosine kinase 1 - Jekyll Hidden behind HydeNeutralizing S1P inhibits intratumoral hypoxia, induces vascular remodelling and sensitizes to chemotherapy in prostate cancer.Anti-cancer effect of pristimerin by inhibition of HIF-1α involves the SPHK-1 pathway in hypoxic prostate cancer cells.Sphingosine 1-phosphate (S1P) receptors 1 and 2 coordinately induce mesenchymal cell migration through S1P activation of complementary kinase pathwaysEssential role for SphK1/S1P signaling to regulate hypoxia-inducible factor 2α expression and activity in cancer.Sphingosine-1-Phosphate as a Regulator of Hypoxia-Induced Factor-1α in Thyroid Follicular Carcinoma CellsSphingosine Kinase-1 Involves the Inhibitory Action of HIF-1α by Chlorogenic Acid in Hypoxic DU145 Cells.Eicosanoids and other lipid mediators and the tumor hypoxic microenvironment.Pharmacological targets in the renal peritubular microenvironment: implications for therapy for sepsis-induced acute kidney injury.Enhanced expression of transferrin receptor 1 contributes to oncogenic signalling by sphingosine kinase 1.Mucins 1-shRNA inhibit the proliferation and HIF-1alpha protein expression on human cholangiocarcinoma cells.Sphingosine kinase 1 pathway is involved in melatonin-induced HIF-1α inactivation in hypoxic PC-3 prostate cancer cells.Single-cell analysis of phosphoinositide 3-kinase and phosphatase and tensin homolog activationA key role of PGC-1α transcriptional coactivator in production of VEGF by a novel angiogenic agent COA-Cl in cultured human fibroblasts.Sphingosine kinase 2 mediates cerebral preconditioning and protects the mouse brain against ischemic injury.Chemical Hypoxia Brings to Light Altered Autocrine Sphingosine-1-Phosphate Signalling in Rheumatoid Arthritis Synovial FibroblastsSphingosine Kinase 1 and Sphingosine-1-Phosphate Signaling in Colorectal Cancer.Berberine Preconditioning Protects Neurons Against Ischemia via Sphingosine-1-Phosphate and Hypoxia-Inducible Factor-1[Formula: see text].Immunohistochemical Detection of Sphingosine-1-Phosphate and Sphingosine Kinase-1 in Human Tissue Samples and Cell Lines.Sphingosine kinase 1 overexpression is associated with poor prognosis and oxaliplatin resistance in hepatocellular carcinoma.
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When the sphingosine kinase 1/sphingosine 1-phosphate pathway meets hypoxia signaling: new targets for cancer therapy.
description
article científic
@ca
article scientifique
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articolo scientifico
@it
artigo científico
@pt
bilimsel makale
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scientific article published on 21 April 2009
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vedecký článok
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vetenskaplig artikel
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videnskabelig artikel
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vědecký článek
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name
When the sphingosine kinase 1/ ...... ew targets for cancer therapy.
@en
When the sphingosine kinase 1/ ...... ew targets for cancer therapy.
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type
label
When the sphingosine kinase 1/ ...... ew targets for cancer therapy.
@en
When the sphingosine kinase 1/ ...... ew targets for cancer therapy.
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prefLabel
When the sphingosine kinase 1/ ...... ew targets for cancer therapy.
@en
When the sphingosine kinase 1/ ...... ew targets for cancer therapy.
@nl
P1433
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When the sphingosine kinase 1/ ...... new targets for cancer therapy
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P2093
Bernard Malavaud
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P356
10.1158/0008-5472.CAN-09-0389
P407
P577
2009-04-21T00:00:00Z