about
Glutathione peroxidase-1 protects from CD95-induced apoptosisOxidative stress-dependent sphingosine kinase-1 inhibition mediates monoamine oxidase A-associated cardiac cell apoptosisSphingosine kinase-1 is central to androgen-regulated prostate cancer growth and survival.Production of multiple brain-like ganglioside species is dispensable for fas-induced apoptosis of lymphoid cellsCaspase-10 triggers Bid cleavage and caspase cascade activation in FasL-induced apoptosis.Ceramide in apoptosis: a revisited role.Sphingosine kinase expression increases intracellular sphingosine-1-phosphate and promotes cell growth and survival.Sphingosine kinase-1--a potential therapeutic target in cancer.When the sphingosine kinase 1/sphingosine 1-phosphate pathway meets hypoxia signaling: new targets for cancer therapy.Reduced sphingosine kinase-1 and enhanced sphingosine 1-phosphate lyase expression demonstrate deregulated sphingosine 1-phosphate signaling in Alzheimer's disease.Hypoxia-inducible factors and sphingosine 1-phosphate signaling.FTY720 (Fingolimod) Inhibits HIF1 and HIF2 Signaling, Promotes Vascular Remodeling, and Chemosensitizes in Renal Cell Carcinoma Animal Model.Inhibition of the GTPase Rac1 mediates the antimigratory effects of metformin in prostate cancer cells.Synthesis, structures, and selective toxicity to cancer cells of gold(I) complexes involving N-heterocyclic carbene ligands.Synthesis of fluorinated agonist of sphingosine-1-phosphate receptor 1.Osteoblast-derived sphingosine 1-phosphate to induce proliferation and confer resistance to therapeutics to bone metastasis-derived prostate cancer cells.First evidence of sphingosine 1-phosphate lyase protein expression and activity downregulation in human neoplasm: implication for resistance to therapeutics in prostate cancer.Biochemical methods for quantifying sphingolipids: ceramide, sphingosine, sphingosine kinase-1 activity, and sphingosine-1-phosphate.Sphingosine kinase 1 inhibition sensitizes hormone-resistant prostate cancer to docetaxel.Sphingosine kinase 1: a new modulator of hypoxia inducible factor 1alpha during hypoxia in human cancer cells.Chemosensitizing effects of sphingosine kinase-1 inhibition in prostate cancer cell and animal models.Acetaminophen induces a caspase-dependent and Bcl-XL sensitive apoptosis in human hepatoma cells and lymphocytes.The therapeutic potential of HIF-2 antagonism in renal cell carcinoma.N,N-Dimethylsphingosine is a potent competitive inhibitor of sphingosine kinase but not of protein kinase C: modulation of cellular levels of sphingosine 1-phosphate and ceramide.Novel synergistic mechanism for sst2 somatostatin and TNFalpha receptors to induce apoptosis: crosstalk between NF-kappaB and JNK pathways.Differential effects of free and liposome-associated 1-O-octadecyl-2-O-methylglycerophosphocholine on protein kinase C.FTY720 (fingolimod) sensitizes prostate cancer cells to radiotherapy by inhibition of sphingosine kinase-1.The sphingosine kinase-1 survival pathway is a molecular target for the tumor-suppressive tea and wine polyphenols in prostate cancer.Sphingosine generation, cytochrome c release, and activation of caspase-7 in doxorubicin-induced apoptosis of MCF7 breast adenocarcinoma cells.Sphingosine 1-phosphate signaling through its receptor S1P5 promotes chromosome segregation and mitotic progression.Cationic and Neutral N-Heterocyclic Carbene Gold(I) Complexes: Cytotoxicity, NCI-60 screening, Cellular Uptake, Inhibition of Mammalian Thioredoxin Reductase and ROS formation.Inhibition of Cu-amyloid-β by using bifunctional peptides with β-sheet breaker and chelator moieties.Gem GTPase acts upstream Gmip/RhoA to regulate cortical actin remodeling and spindle positioning during early mitosis.[Mechanisms of castration resistance: Intratumoral hypoxia stimulates the androgen receptor expression].First evidence of human meconium glycoasparaginesInvolvement of sphingosine in mitochondria-dependent Fas-induced apoptosis of type II Jurkat T cellsSphingosine 1-phosphate inhibits activation of caspases that cleave poly(ADP-ribose) polymerase and lamins during Fas- and ceramide-mediated apoptosis in Jurkat T lymphocytesDownregulating sphingosine kinase-1 for cancer therapy[Sphingosine 1-phosphate receptors: from biology to physiopathology][SphingomabTM, an anti-sphingosine 1-phosphate antibody to inhibit hypoxia]
P50
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P50
description
researcher ORCID ID = 0000-0003-3346-375X
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wetenschapper
@nl
name
Olivier Cuvillier
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Olivier Cuvillier
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Olivier Cuvillier
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Olivier Cuvillier
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type
label
Olivier Cuvillier
@ast
Olivier Cuvillier
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Olivier Cuvillier
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Olivier Cuvillier
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prefLabel
Olivier Cuvillier
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Olivier Cuvillier
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Olivier Cuvillier
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Olivier Cuvillier
@nl
P106
P1153
6602158182
6602158183
P31
P496
0000-0003-3346-375X