Suppression of phosphatidylinositol 3,4,5-trisphosphate production is a key determinant of B cell anergy.
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Gq-Coupled Receptors in AutoimmunitySignaling by the phosphoinositide 3-kinase family in immune cellsPathways leading to an immunological disease: systemic lupus erythematosus.Multiple tolerance defects contribute to the breach of B cell tolerance in New Zealand Black chromosome 1 congenic miceG alpha q-containing G proteins regulate B cell selection and survival and are required to prevent B cell-dependent autoimmunityMolecular underpinning of B-cell anergy.The conundrum of inhibitory signaling by ITAM-containing immunoreceptors: potential molecular mechanisms.FOXO1 transcription factor: a critical effector of the PI3K-AKT axis in B-cell development.Emergence of the PI3-kinase pathway as a central modulator of normal and aberrant B cell differentiationMonophosphorylation of CD79a and CD79b ITAM motifs initiates a SHIP-1 phosphatase-mediated inhibitory signaling cascade required for B cell anergy.PI3Ks in lymphocyte signaling and developmentB cell expression of the SH2-containing inositol 5-phosphatase (SHIP-1) is required to establish anergy to high affinity, proteinacious autoantigens.The microRNA miR-148a functions as a critical regulator of B cell tolerance and autoimmunity.The phosphoinositide 3-kinase signaling pathway in normal and malignant B cells: activation mechanisms, regulation and impact on cellular functions.The Therapeutic Potential for PI3K Inhibitors in Autoimmune Rheumatic DiseasesElevated BCR signaling and decreased survival of Lyn-deficient transitional and follicular B cells.PI3K signalling in B- and T-lymphocytes: new developments and therapeutic advancesAutoimmunity risk alleles: hotspots in B cell regulatory signaling pathways.Continuous inhibitory signaling by both SHP-1 and SHIP-1 pathways is required to maintain unresponsiveness of anergic B cells.Phosphatase regulation of immunoreceptor signaling in T cells, B cells and mast cells.A role for IRF8 in B cell anergy.EndoU is a novel regulator of AICD during peripheral B cell selection.Anti-CD79 antibody induces B cell anergy that protects against autoimmunity.Decreased Gαq expression in T cells correlates with enhanced cytokine production and disease activity in systemic lupus erythematosus.The regulating function of heterotrimeric G proteins in the immune system.Aberrant B cell selection and activation in systemic lupus erythematosus.B-lymphocyte tolerance and effector function in immunity and autoimmunity.B cell receptor signaling regulates metabolism in Chronic Lymphocytic Leukemia.Metabolic reprogramming is required for antibody production that is suppressed in anergic but exaggerated in chronically BAFF-exposed B cells.Germinal centers and autoimmune disease in humans and mice.Targeting B cells in treatment of autoimmunity.Calcium Signaling: From Normal B Cell Development to Tolerance Breakdown and Autoimmunity.Impaired B cell function during viral infections due to PTEN-mediated inhibition of the PI3K pathway.Abnormal B-cell maturation in the bone marrow of patients with germline mutations in PIK3CD.Cowden's syndrome with immunodeficiency.Defective PTEN regulation contributes to B cell hyperresponsiveness in systemic lupus erythematosus.Putting on the Brakes: Regulatory Kinases and Phosphatases Maintaining B Cell Anergy.
P2860
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P2860
Suppression of phosphatidylinositol 3,4,5-trisphosphate production is a key determinant of B cell anergy.
description
2009 nî lūn-bûn
@nan
2009年の論文
@ja
2009年学术文章
@wuu
2009年学术文章
@zh-cn
2009年学术文章
@zh-hans
2009年学术文章
@zh-my
2009年学术文章
@zh-sg
2009年學術文章
@yue
2009年學術文章
@zh
2009年學術文章
@zh-hant
name
Suppression of phosphatidylino ...... determinant of B cell anergy.
@en
Suppression of phosphatidylino ...... determinant of B cell anergy.
@nl
type
label
Suppression of phosphatidylino ...... determinant of B cell anergy.
@en
Suppression of phosphatidylino ...... determinant of B cell anergy.
@nl
prefLabel
Suppression of phosphatidylino ...... determinant of B cell anergy.
@en
Suppression of phosphatidylino ...... determinant of B cell anergy.
@nl
P2093
P2860
P1433
P1476
Suppression of phosphatidylino ...... determinant of B cell anergy.
@en
P2093
Cecille D Browne
Christopher J Del Nagro
Hart S Dengler
Matthew H Cato
Robert C Rickert
P2860
P304
P356
10.1016/J.IMMUNI.2009.08.026
P407
P577
2009-11-05T00:00:00Z