Akt increases sarcoplasmic reticulum Ca2+ cycling by direct phosphorylation of phospholamban at Thr17.
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Optimization of cardiac metabolism in heart failureDiabetic cardiomyopathy: signaling defects and therapeutic approachesAnthrax lethal toxin induces acute diastolic dysfunction in rats through disruption of the phospholamban signaling networkExcitation-contraction coupling in ventricular myocytes is enhanced by paracrine signaling from mesenchymal stem cells.β2-Adrenergic receptor signaling in the cardiac myocyte is modulated by interactions with CXCR4TNNI3K, a cardiac-specific kinase, promotes physiological cardiac hypertrophy in transgenic mice.Mechanosensing and Regulation of Cardiac Function.Physiological activation of Akt by PHLPP1 deletion protects against pathological hypertrophyPhosphorylation and mutation of phospholamban alter physical interactions with the sarcoplasmic reticulum calcium pumpAKT signalling in the failing heartCatestatin exerts direct protective effects on rat cardiomyocytes undergoing ischemia/reperfusion by stimulating PI3K-Akt-GSK3β pathway and preserving mitochondrial membrane potentialSynergistic effects between phosphorylation of phospholamban and troponin I promote relaxation at higher heart rateA study in Polish patients with cardiomyopathy emphasizes pathogenicity of phospholamban (PLN) mutations at amino acid position 9 and low penetrance of heterozygous null PLN mutations.The antioxidant compound tert-butylhydroquinone activates Akt in myocardium, suppresses apoptosis and ameliorates pressure overload-induced cardiac dysfunctionMyocardial AKT: the omnipresent nexus.Luteolin improves cardiac dysfunction in heart failure rats by regulating sarcoplasmic reticulum Ca2+-ATPase 2a.Deception in simplicity: hereditary phospholamban mutations in dilated cardiomyopathy.Secondary structure, backbone dynamics, and structural topology of phospholamban and its phosphorylated and Arg9Cys-mutated forms in phospholipid bilayers utilizing 13C and 15N solid-state NMR spectroscopy.Loss of myocardial retinoic acid receptor α induces diastolic dysfunction by promoting intracellular oxidative stress and calcium mishandling in adult mice.H-Ras Isoform Mediates Protection Against Pressure Overload-Induced Cardiac Dysfunction in Part Through Activation of AKT.Effect of the long-acting insulin analogues glargine and degludec on cardiomyocyte cell signalling and function.Probing the interaction of Arg9Cys mutated phospholamban with phospholipid bilayers by solid-state NMR spectroscopy.Conformational memory in the association of the transmembrane protein phospholamban with the sarcoplasmic reticulum calcium pump SERCA.The Rho kinase inhibitor, fasudil, ameliorates diabetes-induced cardiac dysfunction by improving calcium clearance and actin remodeling.Baicalein Rescues Delayed Cooling via Preservation of Akt Activation and Akt-Mediated Phospholamban Phosphorylation.Acute systemic insulin intolerance does not alter the response of the Akt/GSK-3 pathway to environmental hypoxia in human skeletal muscle.
P2860
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P2860
Akt increases sarcoplasmic reticulum Ca2+ cycling by direct phosphorylation of phospholamban at Thr17.
description
article científic
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article scientifique
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articolo scientifico
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artigo científico
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bilimsel makale
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scientific article published on 19 August 2009
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vedecký článok
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vetenskaplig artikel
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videnskabelig artikel
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vědecký článek
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name
Akt increases sarcoplasmic ret ...... ion of phospholamban at Thr17.
@en
Akt increases sarcoplasmic ret ...... ion of phospholamban at Thr17.
@nl
type
label
Akt increases sarcoplasmic ret ...... ion of phospholamban at Thr17.
@en
Akt increases sarcoplasmic ret ...... ion of phospholamban at Thr17.
@nl
prefLabel
Akt increases sarcoplasmic ret ...... ion of phospholamban at Thr17.
@en
Akt increases sarcoplasmic ret ...... ion of phospholamban at Thr17.
@nl
P2093
P2860
P356
P1476
Akt increases sarcoplasmic ret ...... ion of phospholamban at Thr17.
@en
P2093
Alfonso Bellacosa
Daniele Catalucci
Francesca Rusconi
Gianluigi Condorelli
Howard S Young
Joan Heller Brown
Marcello Ceci
Marco Santonastasi
Michael V G Latronico
Paolo Gallo
P2860
P304
28180-28187
P356
10.1074/JBC.M109.036566
P407
P577
2009-08-19T00:00:00Z