Amyloid beta-protein reduces acetylcholine synthesis in a cell line derived from cholinergic neurons of the basal forebrain.
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The Amyloid Precursor Protein is rapidly transported from the Golgi apparatus to the lysosome and where it is processed into beta-amyloid.Rapid and direct transport of cell surface APP to the lysosome defines a novel selective pathway.Arf6 controls beta-amyloid production by regulating macropinocytosis of the Amyloid Precursor Protein to lysosomesThe modular systems biology approach to investigate the control of apoptosis in Alzheimer's disease neurodegeneration.Aluminum, NO, and nerve growth factor neurotoxicity in cholinergic neurons.Alzheimer's disease and metals: a review of the involvement of cellular membrane receptors in metallosignalling.IGF2 ameliorates amyloidosis, increases cholinergic marker expression and raises BMP9 and neurotrophin levels in the hippocampus of the APPswePS1dE9 Alzheimer's disease model mice.Interactions between beta-amyloid and central cholinergic neurons: implications for Alzheimer's disease.Tyrosine Binding Protein Sites Regulate the Intracellular Trafficking and Processing of Amyloid Precursor Protein through a Novel Lysosome-Directed Pathway.A model for dynamic regulation of choline acetyltransferase by phosphorylation.Perinatal Choline Supplementation Reduces Amyloidosis and Increases Choline Acetyltransferase Expression in the Hippocampus of the APPswePS1dE9 Alzheimer's Disease Model MiceAmyloidosis in Alzheimer's Disease: The Toxicity of Amyloid Beta (A β ), Mechanisms of Its Accumulation and Implications of Medicinal Plants for TherapyAlterations of some membrane transport proteins in Alzheimer's disease: role of amyloid beta-peptide.All-trans retinoic acid as a novel therapeutic strategy for Alzheimer's diseaseTaurine and central nervous system disorders.Cholinergic modulation of the hippocampal region and memory function.Pharmacological models in Alzheimer's disease researchCholinergic System and Post-translational Modifications: An Insight on the Role in Alzheimer's Diseaseβ-Amyloid-acetylcholine molecular interaction: new role of cholinergic mediators in anti-Alzheimer therapy?Differential regulation of the high-affinity choline transporter by wild-type and Swedish mutant amyloid precursor protein.Effects of zinc on SN56 cholinergic neuroblastoma cells.Amyloid-beta binds catalase with high affinity and inhibits hydrogen peroxide breakdownAmyloid beta-peptide 25-35 reduces [3H]acetylcholine release in retinal neurons. Involvement of metabolic dysfunction.Phosphorylation of 69-kDa choline acetyltransferase at threonine 456 in response to amyloid-beta peptide 1-42.Amino-Terminal β-Amyloid Antibody Blocks β-Amyloid-Mediated Inhibition of the High-Affinity Choline Transporter CHT.Altered calcium homeostasis and mitochondrial dysfunction in cortical synaptic compartments of presenilin-1 mutant mice.Oxidative Stress, Amyloid-β Peptide, and Altered Key Molecular Pathways in the Pathogenesis and Progression of Alzheimer's Disease.Soluble Aβ42 Acts as Allosteric Activator of the Core Cholinergic Enzyme Choline Acetyltransferase
P2860
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P2860
Amyloid beta-protein reduces acetylcholine synthesis in a cell line derived from cholinergic neurons of the basal forebrain.
description
article científic
@ca
article scientifique
@fr
articolo scientifico
@it
artigo científico
@pt
bilimsel makale
@tr
scientific article published on July 1996
@en
vedecký článok
@sk
vetenskaplig artikel
@sv
videnskabelig artikel
@da
vědecký článek
@cs
name
Amyloid beta-protein reduces a ...... eurons of the basal forebrain.
@en
Amyloid beta-protein reduces a ...... eurons of the basal forebrain.
@nl
type
label
Amyloid beta-protein reduces a ...... eurons of the basal forebrain.
@en
Amyloid beta-protein reduces a ...... eurons of the basal forebrain.
@nl
prefLabel
Amyloid beta-protein reduces a ...... eurons of the basal forebrain.
@en
Amyloid beta-protein reduces a ...... eurons of the basal forebrain.
@nl
P2860
P356
P1476
Amyloid beta-protein reduces a ...... neurons of the basal forebrain
@en
P2093
M A Kloczewiak
W A Pedersen
P2860
P304
P356
10.1073/PNAS.93.15.8068
P407
P50
P577
1996-07-01T00:00:00Z