Mitochondrial decay in the brains of old rats: ameliorating effect of alpha-lipoic acid and acetyl-L-carnitine. - Wikidata - wikimedia - TriplyDB

Mitochondrial decay in the brains of old rats: ameliorating effect of alpha-lipoic acid and acetyl-L-carnitine.

Mitochondrial decay in the brains of old rats: ameliorating effect of alpha-lipoic acid and acetyl-L-carnitine.

http://www.wikidata.org/entity/Q37465744

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Novel therapeutics for Alzheimer's disease: an update Neuronal failure in Alzheimer's disease: a view through the oxidative stress looking-glass An acetyl-L-carnitine switch on mitochondrial dysfunction and rescue in the metabolomics study on aluminum oxide nanoparticles Biochemical and genetic alterations of oxidant/antioxidant status of the brain in rats treated with dexamethasone: protective roles of melatonin and acetyl-L-carnitine Recombinant human mitochondrial transcription factor A stimulates mitochondrial biogenesis and ATP synthesis, improves motor function after MPTP, reduces oxidative stress and increases survival after endotoxin Age-related changes in mitochondrial respiration and oxidative damage in the cerebral cortex of the Fischer 344 rat.Acetyl-L-carnitine ameliorates mitochondrial dysfunction following contusion spinal cord injury.Mitochondrial dynamics in Alzheimer's disease: opportunities for future treatment strategies.Prevention of mutation, cancer, and other age-associated diseases by optimizing micronutrient intake.Oxygen glucose deprivation in rat hippocampal slice cultures results in alterations in carnitine homeostasis and mitochondrial dysfunction.Neuroprotective strategies involving ROS in Alzheimer disease.Frontiers in Alzheimer's disease therapeutics.Neuroprotective effects of L-carnitine against oxygen-glucose deprivation in rat primary cortical neurons Preserving mitochondrial function prevents the proteasomal degradation of GTP cyclohydrolase I.A complex dietary supplement augments spatial learning, brain mass, and mitochondrial electron transport chain activity in aging mice.Short-term supplementation with acetyl-L-carnitine and lipoic acid alters plasma protein carbonyl levels but does not improve cognition in aged beagles.Maternal L-Carnitine Supplementation Improves Brain Health in Offspring from Cigarette Smoke Exposed Mothers Oxidative stress and Alzheimer's disease: dietary polyphenols as potential therapeutic agents.Lipoic acid: energy metabolism and redox regulation of transcription and cell signaling Strategies for the discovery of anti-aging compounds.Effects of polyphenols on brain ageing and Alzheimer's disease: focus on mitochondria.Mitochondrial free radical theory of aging: who moved my premise?Oxidative Stress Induced Mitochondrial Failure and Vascular Hypoperfusion as a Key Initiator for the Development of Alzheimer Disease.Effects of α-lipoic acid and L-carnosine supplementation on antioxidant activities and lipid profiles in rats.In vivo and in vitro assessment of brain bioenergetics in aging rats.Vitamin C, resveratrol and lipoic acid actions on isolated rat liver mitochondria: all antioxidants but different.Rice bran extract improves mitochondrial dysfunction in brains of aged NMRI mice.Early changes in oxidative stress markers in a rat model of acute stress: effect of l-carnitine on the striatum.Effect of in vivo L-acetylcarnitine administration on ATP-ases enzyme systems of synaptic plasma membranes from rat cerebral cortex.

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Mitochondrial decay in the brains of old rats: ameliorating effect of alpha-lipoic acid and acetyl-L-carnitine.

http://www.wikidata.org/entity/Q37465744

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article científic

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article scientifique

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articolo scientifico

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artigo científico

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bilimsel makale

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scientific article published on 10 October 2008

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vedecký článok

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vetenskaplig artikel

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vědecký článek

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name

Mitochondrial decay in the bra ...... c acid and acetyl-L-carnitine.

@en

Mitochondrial decay in the bra ...... c acid and acetyl-L-carnitine.

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Mitochondrial decay in the bra ...... c acid and acetyl-L-carnitine.

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Mitochondrial decay in the bra ...... c acid and acetyl-L-carnitine.

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Mitochondrial decay in the bra ...... c acid and acetyl-L-carnitine.

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Mitochondrial decay in the bra ...... c acid and acetyl-L-carnitine.

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S11064-008-9850-2

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Neurochemical Research

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Mitochondrial decay in the bra ...... c acid and acetyl-L-carnitine.

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Bruce N Ames

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Carl W Cotman

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Feng Gao

http://www.w3.org/2001/XMLSchema#string

Jiangang Long

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Jiankang Liu

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Liqi Tong

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P2860

Memory loss in old rats is associated with brain mitochondrial decay and RNA/DNA oxidation: partial reversal by feeding acetyl-L-carnitine and/or R-alpha -lipoic acid

Involvement of PI3K/PKG/ERK1/2 signaling pathways in cortical neurons to trigger protection by cotreatment of acetyl-L-carnitine and alpha-lipoic acid against HNE-mediated oxidative stress and neurotoxicity: implications for Alzheimer's disease

alpha-Lipoic acid as a biological antioxidant.

High-dose vitamin therapy stimulates variant enzymes with decreased coenzyme binding affinity (increased K(m)): relevance to genetic disease and polymorphisms

Malonaldehyde acts as a mitochondrial toxin: Inhibitory effects on respiratory function and enzyme activities in isolated rat liver mitochondria

Age-associated increases in oxidative stress and antioxidant enzyme activities in cardiac interfibrillar mitochondria: implications for the mitochondrial theory of aging

Mitochondria, oxidants, and aging

High frequency of mitochondrial complex I mutations in Parkinson's disease and aging.

Parkinson's disease brain mitochondrial complex I has oxidatively damaged subunits and is functionally impaired and misassembled.

Aconitase and ATP synthase are targets of malondialdehyde modification and undergo an age-related decrease in activity in mouse heart mitochondria.

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