Tumor necrosis factor alpha represses bone morphogenetic protein (BMP) signaling by interfering with the DNA binding of Smads through the activation of NF-kappaB.
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Tumor necrosis factor α inhibits expression of the iron regulating hormone hepcidin in murine models of innate colitisRole of TNF alpha and PLF in bone remodeling in a rat model of repetitive reaching and graspingAccumulation of p100, a precursor of NF-κB2, enhances osteoblastic differentiation in vitro and bone formation in vivo in aly/aly mice.Glucocorticoid-induced leucine zipper (GILZ) antagonizes TNF-α inhibition of mesenchymal stem cell osteogenic differentiation.Involvement of PRIP, phospholipase C-related, but catalytically inactive protein, in bone formation.Role of NF-κB in the skeletonImpact of targeted PPARγ disruption on bone remodeling.miR-30 family members negatively regulate osteoblast differentiation.The current and future therapies of bone regeneration to repair bone defects.Cyclic AMP Response Element-binding Protein H (CREBH) Mediates the Inhibitory Actions of Tumor Necrosis Factor α in Osteoblast Differentiation by Stimulating Smad1 Degradation.Osteoblast-like differentiation of cultured human coronary artery smooth muscle cells by bone morphogenetic protein endothelial cell precursor-derived regulator (BMPER)Mechanical strain promotes osteoblast ECM formation and improves its osteoinductive potential.NF-κB Has a Direct Role in Inhibiting Bmp- and Wnt-Induced Matrix Protein Expression.Activated NF-κB in bone marrow mesenchymal stem cells from systemic lupus erythematosus patients inhibits osteogenic differentiation through downregulating Smad signaling.Autophagy regulates odontoblast differentiation by suppressing NF-κB activation in an inflammatory environment.Bone formation in rabbit cancellous bone explant culture model is enhanced by mechanical load.Nuclear factor-κB modulates osteogenesis of periodontal ligament stem cells through competition with β-catenin signaling in inflammatory microenvironments.LPS-stimulated inflammatory environment inhibits BMP-2-induced osteoblastic differentiation through crosstalk between TLR4/MyD88/NF-κB and BMP/Smad signaling.Marrow adipocytes inhibit the differentiation of mesenchymal stem cells into osteoblasts via suppressing BMP-signaling.Neonatal High Bone Mass With First Mutation of the NF-κB Complex: Heterozygous De Novo Missense (p.Asp512Ser) RELA (Rela/p65).NF-κB RelB negatively regulates osteoblast differentiation and bone formation.Anti-cancer IAP antagonists promote bone metastasis: a cautionary tale.Extracellular S100A4 negatively regulates osteoblast function by activating the NF-κB pathway.Opposing TNF-α/IL-1β- and BMP-2-activated MAPK signaling pathways converge on Runx2 to regulate BMP-2-induced osteoblastic differentiation.Classical and Paradoxical Effects of TNF-α on Bone Homeostasis.Differentially expressed genes in PPARγ-deficient MSCs.Regulatory effects of bone morphogenetic protein-4 on tumour necrosis factor-α-suppressed Runx2 and osteoprotegerin expression in cementoblasts.A Review of the Clinical Side Effects of Bone Morphogenetic Protein-2.Rocaglamide-A Potentiates Osteoblast Differentiation by Inhibiting NF-κB Signaling.Smad9 is a new type of transcriptional regulator in bone morphogenetic protein signalingBMP-2 and titanium particles synergistically activate osteoclast formationDifferent Modulatory Effects of IL-17, IL-22, and IL-23 on Osteoblast Differentiation.Cytoskeleton and nuclear lamina affection in recessive osteogenesis imperfecta: A functional proteomics perspective.Double-edged-sword effect of IL-1β on the osteogenesis of periodontal ligament stem cells via crosstalk between the NF-κB, MAPK and BMP/Smad signaling pathways.Inhibition of BMP2-induced bone formation by the p65 subunit of NF-κB via an interaction with Smad4.Involvement of BMPs/Smad signaling pathway in mechanical response in osteoblasts.Interactions of enamel matrix derivative and biomechanical loading in periodontal regenerative healing.Alpha-Lipoic Acid Promotes Osteoblastic Formation in H2O2 -Treated MC3T3-E1 Cells and Prevents Bone Loss in Ovariectomized Rats.Inflammatory Bowel Disease: Effects on Bone and Mechanisms.TNF-α inhibits SATB2 expression and osteoblast differentiation through NF-κB and MAPK pathways.
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Tumor necrosis factor alpha represses bone morphogenetic protein (BMP) signaling by interfering with the DNA binding of Smads through the activation of NF-kappaB.
description
article científic
@ca
article scientifique
@fr
articolo scientifico
@it
artigo científico
@pt
bilimsel makale
@tr
scientific article published on December 2009
@en
vedecký článok
@sk
vetenskaplig artikel
@sv
videnskabelig artikel
@da
vědecký článek
@cs
name
Tumor necrosis factor alpha re ...... h the activation of NF-kappaB.
@en
Tumor necrosis factor alpha represses bone morphogenetic protein
@nl
type
label
Tumor necrosis factor alpha re ...... h the activation of NF-kappaB.
@en
Tumor necrosis factor alpha represses bone morphogenetic protein
@nl
prefLabel
Tumor necrosis factor alpha re ...... h the activation of NF-kappaB.
@en
Tumor necrosis factor alpha represses bone morphogenetic protein
@nl
P2093
P2860
P356
P1476
Tumor necrosis factor alpha re ...... h the activation of NF-kappaB.
@en
P2093
Eijiro Jimi
Hidefumi Fukushima
Masashi Shin
Masato Yamazaki
Takahiro Doi
Takenobu Katagiri
Tetsu Takahashi
P2860
P304
35987-35995
P356
10.1074/JBC.M109.070540
P407
P577
2009-12-01T00:00:00Z