Erbin and the NF2 tumor suppressor Merlin cooperatively regulate cell-type-specific activation of PAK2 by TGF-beta.
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FRAX597, a Small Molecule Inhibitor of the p21-activated Kinases, Inhibits Tumorigenesis of Neurofibromatosis Type 2 (NF2)-associated SchwannomasMerlin, a "magic" linker between extracellular cues and intracellular signaling pathways that regulate cell motility, proliferation, and survivalP21-activated kinase-2 is a critical mediator of transforming growth factor-β-induced hepatoma cell migrationMicroarray analysis of gene expression in vestibular schwannomas reveals SPP1/MET signaling pathway and androgen receptor deregulation.The tale of transforming growth factor-beta (TGFbeta) signaling: a soigné enigma.Tgf-beta induced Erk phosphorylation of smad linker region regulates smad signaling.c-Myb regulates cell cycle-dependent expression of Erbin: an implication for a novel function of Erbin.Non-Smad transforming growth factor-β signaling regulated by focal adhesion kinase binding the p85 subunit of phosphatidylinositol 3-kinase.Activation of Rac-1 and RhoA contributes to podocyte injury in chronic kidney disease.Merlin: a tumour suppressor with functions at the cell cortex and in the nucleus.p21-Activated kinase 2 (PAK2) inhibits TGF-β signaling in Madin-Darby canine kidney (MDCK) epithelial cells by interfering with the receptor-Smad interactionDesmoglein-1/Erbin interaction suppresses ERK activation to support epidermal differentiation.Development of small-molecule inhibitors of the group I p21-activated kinases, emerging therapeutic targets in cancer.Peptidoglycan: a critical activator of the mammalian immune system during infection and homeostasis.Signaling by the TGFβ superfamily.Cell type specificity of signaling: view from membrane receptors distribution and their downstream transduction networks.Cell-penetrating peptides selectively targeting SMAD3 inhibit profibrotic TGF-β signaling.NF2 binds PAK1Erbin interacts with c-Cbl and promotes tumourigenesis and tumour growth in colorectal cancer by preventing c-Cbl-mediated ubiquitination and down-regulation of EGFR.
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P2860
Erbin and the NF2 tumor suppressor Merlin cooperatively regulate cell-type-specific activation of PAK2 by TGF-beta.
description
article científic
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article scientifique
@fr
articolo scientifico
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artigo científico
@pt
bilimsel makale
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scientific article published on March 2009
@en
vedecký článok
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vetenskaplig artikel
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videnskabelig artikel
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vědecký článek
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name
Erbin and the NF2 tumor suppre ...... ctivation of PAK2 by TGF-beta.
@en
Erbin and the NF2 tumor suppre ...... ctivation of PAK2 by TGF-beta.
@nl
type
label
Erbin and the NF2 tumor suppre ...... ctivation of PAK2 by TGF-beta.
@en
Erbin and the NF2 tumor suppre ...... ctivation of PAK2 by TGF-beta.
@nl
prefLabel
Erbin and the NF2 tumor suppre ...... ctivation of PAK2 by TGF-beta.
@en
Erbin and the NF2 tumor suppre ...... ctivation of PAK2 by TGF-beta.
@nl
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Erbin and the NF2 tumor suppre ...... activation of PAK2 by TGF-beta
@en
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Claire E Repellin
Edward B Leof
Margarita Bracamonte
Mark C Wilkes
Sumedha G Penheiter
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P304
P356
10.1016/J.DEVCEL.2009.01.009
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P577
2009-03-01T00:00:00Z