It takes two to tango: regulation of G proteins by dimerization.
about
Biochemical characterization of highly purified leucine-rich repeat kinases 1 and 2 demonstrates formation of homodimersGTPase activity regulates kinase activity and cellular phenotypes of Parkinson's disease-associated LRRK2Insight into the mode of action of the LRRK2 Y1699C pathogenic mutantStructural basis for conformational switching and GTP loading of the large G protein atlastinGTP binding controls complex formation by the human ROCO protein MASL1Parkinson-related LRRK2 mutation R1441C/G/H impairs PKA phosphorylation of LRRK2 and disrupts its interaction with 14-3-3The activation mechanism of Irga6, an interferon-inducible GTPase contributing to mouse resistance against Toxoplasma gondiiLRRK2 regulates autophagic activity and localizes to specific membrane microdomains in a novel human genomic reporter cellular modelA tale of two GTPases in cotranslational protein targetingHeterogeneity of leucine-rich repeat kinase 2 mutations: genetics, mechanisms and therapeutic implicationsThe universally conserved prokaryotic GTPasesIs inhibition of kinase activity the only therapeutic strategy for LRRK2-associated Parkinson's disease?Kissing G domains of MnmE monitored by X-ray crystallography and pulse electron paramagnetic resonance spectroscopyGTP-induced conformational changes in septins and implications for functionG domain dimerization controls dynamin's assembly-stimulated GTPase activityStructural basis of oligomerization in septin-like GTPase of immunity-associated protein 2 (GIMAP2)Structural basis for the nucleotide-dependent dimerization of the large G protein atlastin-1/SPG3AStructural analysis of the Ras-like G protein MglA and its cognate GAP MglB and implications for bacterial polarityPotassium Acts as a GTPase-Activating Element on Each Nucleotide-Binding Domain of the Essential Bacillus subtilis EngAAssembly of Preactivation Complex for Urease Maturation in Helicobacter pylori: CRYSTAL STRUCTURE OF UreF-UreH PROTEIN COMPLEXCrystal structure of the small GTPase Arl6/BBS3 fromTrypanosoma bruceiStructural basis for the molecular evolution of SRP-GTPase activation by proteinStructural basis for mechanochemical role of Arabidopsis thaliana dynamin-related protein in membrane fissionStructural Basis for GTP-Dependent Dimerization of Hydrogenase Maturation Factor HypBStructure of UreG/UreF/UreH complex reveals how urease accessory proteins facilitate maturation of Helicobacter pylori ureaseThe Structural Basis of FtsY Recruitment and GTPase Activation by SRP RNARoco kinase structures give insights into the mechanism of Parkinson disease-related leucine-rich-repeat kinase 2 mutationsRevisiting the Roco G-protein cycleInvited review: Mechanisms of GTP hydrolysis and conformational transitions in the dynamin superfamilyInhibition of LRRK2 kinase activity stimulates macroautophagyIn silico docking of forchlorfenuron (FCF) to septins suggests that FCF interferes with GTP bindingVimar Is a Novel Regulator of Mitochondrial Fission through MiroA monovalent cation acts as structural and catalytic cofactor in translational GTPasesProtective LRRK2 R1398H Variant Enhances GTPase and Wnt Signaling Activity.New insights into the mechanism of chloroplast protein import and its integration with protein quality control, organelle biogenesis and development.Chloroplast Omp85 proteins change orientation during evolution.H-Ras forms dimers on membrane surfaces via a protein-protein interface.Ras Dimer Formation as a New Signaling Mechanism and Potential Cancer Therapeutic Target.Regulation of cargo recognition, commitment, and unloading drives cotranslational protein targetingIntracellular trafficking of guanylate-binding proteins is regulated by heterodimerization in a hierarchical manner.
P2860
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P2860
It takes two to tango: regulation of G proteins by dimerization.
description
article científic
@ca
article scientifique
@fr
articolo scientifico
@it
artigo científico
@pt
bilimsel makale
@tr
scientific article published on 08 May 2009
@en
vedecký článok
@sk
vetenskaplig artikel
@sv
videnskabelig artikel
@da
vědecký článek
@cs
name
It takes two to tango: regulation of G proteins by dimerization.
@en
It takes two to tango: regulation of G proteins by dimerization.
@nl
type
label
It takes two to tango: regulation of G proteins by dimerization.
@en
It takes two to tango: regulation of G proteins by dimerization.
@nl
prefLabel
It takes two to tango: regulation of G proteins by dimerization.
@en
It takes two to tango: regulation of G proteins by dimerization.
@nl
P2093
P356
P1476
It takes two to tango: regulation of G proteins by dimerization.
@en
P2093
Katja Gotthardt
Raphael Gasper
Simon Meyer
P2888
P304
P356
10.1038/NRM2689
P577
2009-05-08T00:00:00Z