AFF1 is a ubiquitous P-TEFb partner to enable Tat extraction of P-TEFb from 7SK snRNP and formation of SECs for HIV transactivation.
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Crystal structure of HIV-1 Tat complexed with human P-TEFb and AFF4AFF4 binding to Tat-P-TEFb indirectly stimulates TAR recognition of super elongation complexes at the HIV promoterhLARP7 C-terminal domain contains an xRRM that binds the 3' hairpin of 7SK RNABrd4 activates P-TEFb for RNA polymerase II CTD phosphorylationCracking the control of RNA polymerase II elongation by 7SK snRNP and P-TEFbActivation of HIV transcription with short-course vorinostat in HIV-infected patients on suppressive antiretroviral therapyA Natural Product from Polygonum cuspidatum Sieb. Et Zucc. Promotes Tat-Dependent HIV Latency Reversal through Triggering P-TEFb's Release from 7SK snRNPMechanism and factors that control HIV-1 transcription and latency activationReconstitution of a functional 7SK snRNPLARP7 suppresses P-TEFb activity to inhibit breast cancer progression and metastasis.A Cyclin T1 point mutation that abolishes positive transcription elongation factor (P-TEFb) binding to Hexim1 and HIV tatCompensatory induction of MYC expression by sustained CDK9 inhibition via a BRD4-dependent mechanismGene target specificity of the Super Elongation Complex (SEC) family: how HIV-1 Tat employs selected SEC members to activate viral transcription.BET-Inhibitors Disrupt Rad21-Dependent Conformational Control of KSHV LatencyA Minor Subset of Super Elongation Complexes Plays a Predominant Role in Reversing HIV-1 Latency.Insights into HIV-1 proviral transcription from integrative structure and dynamics of the Tat:AFF4:P-TEFb:TAR complex.Structural basis for ELL2 and AFF4 activation of HIV-1 proviral transcriptionRole of Host Factors on the Regulation of Tat-Mediated HIV-1 Transcription.Improving combination antiretroviral therapy by targeting HIV-1 gene transcription.Regulation of RNA polymerase II-mediated transcriptional elongation: Implications in human disease.A chalcone derivative reactivates latent HIV-1 transcription through activating P-TEFb and promoting Tat-SEC interaction on viral promoter.Super elongation complex promotes early HIV transcription and its function is modulated by P-TEFb.Pseudouridylation of 7SK snRNA promotes 7SK snRNP formation to suppress HIV-1 transcription and escape from latency.Mechanisms and Developmental Roles of Promoter-proximal Pausing of RNA Polymerase II.AFF1 and AFF4 differentially regulate the osteogenic differentiation of human MSCs.Making Sense of Multifunctional Proteins: Human Immunodeficiency Virus Type 1 Accessory and Regulatory Proteins and Connections to Transcription.A single point mutation in cyclin T1 eliminates binding to Hexim1, Cdk9 and RNA but not to AFF4 and enforces repression of HIV transcription.The HIV-1 Tat protein recruits a ubiquitin ligase to reorganize the 7SK snRNP for transcriptional activation.Positive Regulation of Transcription by Human ZMYND8 through Its Association with P-TEFb ComplexStructural insights into the functional diversity of the CDK-cyclin family
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AFF1 is a ubiquitous P-TEFb partner to enable Tat extraction of P-TEFb from 7SK snRNP and formation of SECs for HIV transactivation.
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article científic
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article scientifique
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articolo scientifico
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artigo científico
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bilimsel makale
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scientific article published on 23 December 2013
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vedecký článok
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vetenskaplig artikel
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videnskabelig artikel
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AFF1 is a ubiquitous P-TEFb pa ...... SECs for HIV transactivation.
@en
AFF1 is a ubiquitous P-TEFb pa ...... SECs for HIV transactivation.
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AFF1 is a ubiquitous P-TEFb pa ...... SECs for HIV transactivation.
@en
AFF1 is a ubiquitous P-TEFb pa ...... SECs for HIV transactivation.
@nl
prefLabel
AFF1 is a ubiquitous P-TEFb pa ...... SECs for HIV transactivation.
@en
AFF1 is a ubiquitous P-TEFb pa ...... SECs for HIV transactivation.
@nl
P2093
P2860
P356
P1476
AFF1 is a ubiquitous P-TEFb pa ...... SECs for HIV transactivation.
@en
P2093
Huasong Lu
Jeffrey R Johnson
Nevan J Krogan
Qiang Zhou
Zichong Li
P2860
P304
P356
10.1073/PNAS.1318503111
P407
P577
2013-12-23T00:00:00Z