Therapeutic targeting of constitutive PARP activation compromises stem cell phenotype and survival of glioblastoma-initiating cells.
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DNA repair and aging: the impact of the p53 familyThe mitotic kinesin KIF11 is a driver of invasion, proliferation, and self-renewal in glioblastoma.Advances in epigenetic glioblastoma therapy.Ionizing radiations sustain glioblastoma cell dedifferentiation to a stem-like phenotype through survivin: possible involvement in radioresistance.The polyamine catabolic enzyme SAT1 modulates tumorigenesis and radiation response in GBMPARP targeting counteracts gliomagenesis through induction of mitotic catastrophe and aggravation of deficiency in homologous recombination in PTEN-mutant gliomaCancer stem cells in glioblastomaAtracurium Besylate and other neuromuscular blocking agents promote astroglial differentiation and deplete glioblastoma stem cellsPreferential Iron Trafficking Characterizes Glioblastoma Stem-like CellsCytomegalovirus infection induces a stem cell phenotype in human primary glioblastoma cells: prognostic significance and biological impactEXPLORING THE ANTITUMOR EFFECT OF VIRUS IN MALIGNANT GLIOMAPatient-Derived Xenografts as a Model System for Radiation ResearchIntratumoral heterogeneity identified at the epigenetic, genetic and transcriptional level in glioblastoma.Chromosomal Instability Affects the Tumorigenicity of Glioblastoma Tumor-Initiating Cells.Targeting the epigenetics of the DNA damage response in breast cancer.BRCA1-regulated RRM2 expression protects glioblastoma cells from endogenous replication stress and promotes tumorigenicity.Altered RECQL5 expression in urothelial bladder carcinoma increases cellular proliferation and makes RECQL5 helicase activity a novel target for chemotherapy.Veliparib in combination with radiotherapy for the treatment of MGMT unmethylated glioblastoma.Radiation oncology in vitro: trends to improve radiotherapy through molecular targets.Chemosensitivity of IDH1-Mutated Gliomas Due to an Impairment in PARP1-Mediated DNA Repair.Opportunities and challenges of radiotherapy for treating cancer.Glioblastoma targeted therapy: updated approaches from recent biological insights.Therapeutic Targeting of Poly(ADP-Ribose) Polymerase-1 (PARP1) in Cancer: Current Developments, Therapeutic Strategies, and Future Opportunities.The Unexpected Roles of Aurora A Kinase in Gliobastoma Recurrences.Combining PARP inhibitors with radiation therapy for the treatment of glioblastoma: Is PTEN predictive of response?The role of cancer stem cells in tumor heterogeneity and resistance to therapy.Enhanced efficacy of combined HDAC and PARP targeting in glioblastoma.Abrogation of radioresistance in glioblastoma stem-like cells by inhibition of ATM kinase.p73 promotes glioblastoma cell invasion by directly activating POSTN (periostin) expression.Anti-oxidative stress response genes: bioinformatic analysis of their expression and relevance in multiple cancers.The Cell Cycle Inhibitors p21Cip1 and p27Kip1 Control Proliferation but Enhance DNA Damage Resistance of Glioma Stem Cells.Targeting hexokinase 2 enhances response to radio-chemotherapy in glioblastoma.Poly-(ADP-ribose)-polymerase inhibitors as radiosensitizers: a systematic review of pre-clinical and clinical human studies.DNA damage responses in cancer stem cells: Implications for cancer therapeutic strategiesRadiosensitization of cancer stem cells in glioblastoma by the simultaneous inhibition of parallel DNA damage response pathways.Pharmacological Targeting of the Histone Chaperone Complex FACT Preferentially Eliminates Glioblastoma Stem Cells and Prolongs Survival in Preclinical ModelsComparative analysis of antioxidative systems in malignant and benign brain tumours.Glioblastoma and glioblastoma stem cells are dependent on functional MTH1.Radiosensitization with an inhibitor of poly(ADP-ribose) glycohydrolase: A comparison with the PARP1/2/3 inhibitor olaparib.Purine synthesis promotes maintenance of brain tumor initiating cells in glioma.
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Therapeutic targeting of constitutive PARP activation compromises stem cell phenotype and survival of glioblastoma-initiating cells.
description
article científic
@ca
article scientifique
@fr
articolo scientifico
@it
artigo científico
@pt
bilimsel makale
@tr
scientific article published on 11 October 2013
@en
vedecký článok
@sk
vetenskaplig artikel
@sv
videnskabelig artikel
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vědecký článek
@cs
name
Therapeutic targeting of const ...... glioblastoma-initiating cells.
@en
Therapeutic targeting of const ...... glioblastoma-initiating cells.
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type
label
Therapeutic targeting of const ...... glioblastoma-initiating cells.
@en
Therapeutic targeting of const ...... glioblastoma-initiating cells.
@nl
prefLabel
Therapeutic targeting of const ...... glioblastoma-initiating cells.
@en
Therapeutic targeting of const ...... glioblastoma-initiating cells.
@nl
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P1476
Therapeutic targeting of const ...... glioblastoma-initiating cells.
@en
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A B Hjelmeland
P Hamerlik
R D Rasmussen
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P2888
P304
P356
10.1038/CDD.2013.136
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2013-10-11T00:00:00Z