Identification of a determinant within the human immunodeficiency virus 1 surface envelope glycoprotein critical for productive infection of primary monocytes.
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Macrophage-tropic variants initiate human immunodeficiency virus type 1 infection after sexual, parenteral, and vertical transmissionViral entry through CXCR4 is a pathogenic factor and therapeutic target in human immunodeficiency virus type 1 diseasePunica granatum (Pomegranate) juice provides an HIV-1 entry inhibitor and candidate topical microbicideSpirodiketopiperazine-based CCR5 inhibitor which preserves CC-chemokine/CCR5 interactions and exerts potent activity against R5 human immunodeficiency virus type 1 in vitroGenetic characterization of human immunodeficiency virus type 1 in blood and genital secretions: evidence for viral compartmentalization and selection during sexual transmissionSensitivity to a nonpeptidic compound (RPR103611) blocking human immunodeficiency virus type 1 Env-mediated fusion depends on sequence and accessibility of the gp41 loop regionAnti-human immunodeficiency virus type 1 activity of an oligocationic compound mediated via gp120 V3 interactionsHuman immunodeficiency virus strains differ in their ability to infect CD4+ cells expressing the rat homolog of CXCR-4 (fusin)Functional stability of unliganded envelope glycoprotein spikes among isolates of human immunodeficiency virus type 1 (HIV-1)Actin cytoskeletal reorganizations and coreceptor-mediated activation of rac during human immunodeficiency virus-induced cell fusionAntiviral efficacy of the novel compound BIT225 against HIV-1 release from human macrophages.Distinct human immunodeficiency virus strains in the bone marrow are associated with the development of thrombocytopenia.Changes in human immunodeficiency virus type 1 envelope glycoproteins responsible for the pathogenicity of a multiply passaged simian-human immunodeficiency virus (SHIV-HXBc2)V3 recombinants indicate a central role for CCR5 as a coreceptor in tissue infection by human immunodeficiency virus type 1.Phenotype-associated env gene variation among eight related human immunodeficiency virus type 1 clones: evidence for in vivo recombination and determinants of cytotropism outside the V3 domain.Human immunodeficiency virus type 1 envelope glycoprotein molecules containing membrane fusion-impairing mutations in the V3 region efficiently undergo soluble CD4-stimulated gp120 release.HIV-1 Transmission, Replication Fitness and Disease Progression.Potent anti-R5 human immunodeficiency virus type 1 effects of a CCR5 antagonist, AK602/ONO4128/GW873140, in a novel human peripheral blood mononuclear cell nonobese diabetic-SCID, interleukin-2 receptor gamma-chain-knocked-out AIDS mouse model.Multiple residues contribute to the inability of murine CCR-5 to function as a coreceptor for macrophage-tropic human immunodeficiency virus type 1 isolates.Identification of determinants on a dualtropic human immunodeficiency virus type 1 envelope glycoprotein that confer usage of CXCR4Determinants of entry cofactor utilization and tropism in a dualtropic human immunodeficiency virus type 1 primary isolate.Evolution of the human immunodeficiency virus type 1 envelope during infection reveals molecular corollaries of specificity for coreceptor utilization and AIDS pathogenesis.Variable constraints on the principal immunodominant domain of the transmembrane glycoprotein of human immunodeficiency virus type 1.Analysis of the critical domain in the V3 loop of human immunodeficiency virus type 1 gp120 involved in CCR5 utilization.trans-dominant interference with human immunodeficiency virus type 1 replication and transmission in CD4(+) cells by an envelope double mutant.N-linked glycosylation sites adjacent to and within the V1/V2 and the V3 loops of dualtropic human immunodeficiency virus type 1 isolate DH12 gp120 affect coreceptor usage and cellular tropismMolecular basis for cell tropism of CXCR4-dependent human immunodeficiency virus type 1 isolatesInduction of rapid and extensive beta-chemokine synthesis in macrophages by human immunodeficiency virus type 1 and gp120, independently of their coreceptor phenotype.Induction of interleukin-1 and tumor necrosis factor alpha in brain cultures by human immunodeficiency virus type 1.Human immunodeficiency virus type 1 tropism for brain microglial cells is determined by a region of the env glycoprotein that also controls macrophage tropism.Human immunodeficiency virus type 1 nef quasispecies in pathological tissueFusogenic selectivity of the envelope glycoprotein is a major determinant of human immunodeficiency virus type 1 tropism for CD4+ T-cell lines vs. primary macrophagesDevelopment of hexadecyloxypropyl tenofovir (CMX157) for treatment of infection caused by wild-type and nucleoside/nucleotide-resistant HIV.Use of murine CXCR-4 as a second receptor by some T-cell-tropic human immunodeficiency virusesDysregulation of macrophage-secreted cathepsin B contributes to HIV-1-linked neuronal apoptosis.CD8+ cell depletion accelerates HIV-1 immunopathology in humanized mice.Potent strategy to inhibit HIV-1 by binding both gp120 and gp41.Selected amino acid mutations in HIV-1 B subtype gp41 are associated with specific gp120v₃ signatures in the regulation of co-receptor usage.Highly potent chimeric inhibitors targeting two steps of HIV cell entryAdaptation to persistent growth in the H9 cell line renders a primary isolate of human immunodeficiency virus type 1 sensitive to neutralization by vaccine sera
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P2860
Identification of a determinant within the human immunodeficiency virus 1 surface envelope glycoprotein critical for productive infection of primary monocytes.
description
article científic
@ca
article scientifique
@fr
articolo scientifico
@it
artigo científico
@pt
bilimsel makale
@tr
scientific article published on April 1991
@en
vedecký článok
@sk
vetenskaplig artikel
@sv
videnskabelig artikel
@da
vědecký článek
@cs
name
Identification of a determinan ...... nfection of primary monocytes.
@en
Identification of a determinan ...... nfection of primary monocytes.
@nl
type
label
Identification of a determinan ...... nfection of primary monocytes.
@en
Identification of a determinan ...... nfection of primary monocytes.
@nl
prefLabel
Identification of a determinan ...... nfection of primary monocytes.
@en
Identification of a determinan ...... nfection of primary monocytes.
@nl
P2093
P2860
P356
P1476
Identification of a determinan ...... nfection of primary monocytes.
@en
P2093
H E Gendelman
P Westervelt
P2860
P304
P356
10.1073/PNAS.88.8.3097
P407
P577
1991-04-01T00:00:00Z