Prion transmission prevented by modifying the β2-α2 loop structure of host PrPC
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Changes in retinal function and morphology are early clinical signs of disease in cattle with bovine spongiform encephalopathyA brief history of prionsStructural effects of PrP polymorphisms on intra- and interspecies prion transmission.Complex folding and misfolding effects of deer-specific amino acid substitutions in the β2-α2 loop of murine prion protein.Human prion protein sequence elements impede cross-species chronic wasting disease transmission.Molecular Mechanisms of Chronic Wasting Disease Prion Propagation.A proposed mechanism for the promotion of prion conversion involving a strictly conserved tyrosine residue in the β2-α2 loop of PrPC.Manipulating the Prion Protein Gene Sequence and Expression Levels with CRISPR/Cas9.A Structural and Functional Comparison Between Infectious and Non-Infectious Autocatalytic Recombinant PrP Conformers.Prion Protein-Antibody Complexes Characterized by Chromatography-Coupled Small-Angle X-Ray Scattering.Protease resistance of infectious prions is suppressed by removal of a single atom in the cellular prion protein.Prion protein β2-α2 loop conformational landscape.The formation, function and regulation of amyloids: insights from structural biology.De Novo Generation of a Unique Cervid Prion Strain Using Protein Misfolding Cyclic Amplification.Toward the Atomic Structure of PrPSc.Implications of peptide assemblies in amyloid diseases.Insights into Mechanisms of Transmission and Pathogenesis from Transgenic Mouse Models of Prion Diseases.Chronic Wasting Disease Prion Strain Emergence and Host Range Expansion.Glycoform-independent prion conversion by highly efficient, cell-based, protein misfolding cyclic amplification.Molecular dynamics studies on the buffalo prion protein.Chronic wasting disease (CWD) in cervidsPrion replication environment defines the fate of prion strain adaptation.
P2860
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P2860
Prion transmission prevented by modifying the β2-α2 loop structure of host PrPC
description
article científic
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article scientifique
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articolo scientifico
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artigo científico
@pt
bilimsel makale
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scientific article published on January 2014
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vedecký článok
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vetenskaplig artikel
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videnskabelig artikel
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vědecký článek
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name
Prion transmission prevented by modifying the β2-α2 loop structure of host PrPC
@en
Prion transmission prevented by modifying the β2-α2 loop structure of host PrPC.
@nl
type
label
Prion transmission prevented by modifying the β2-α2 loop structure of host PrPC
@en
Prion transmission prevented by modifying the β2-α2 loop structure of host PrPC.
@nl
prefLabel
Prion transmission prevented by modifying the β2-α2 loop structure of host PrPC
@en
Prion transmission prevented by modifying the β2-α2 loop structure of host PrPC.
@nl
P2093
P2860
P50
P1476
Prion transmission prevented by modifying the β2-α2 loop structure of host PrPC
@en
P2093
Christina J Sigurdson
Cyrus Bett
Joaquín Castilla
Natalia Fernández-Borges
Shivanjali Joshi-Barr
Thomas Rülicke
Timothy D Kurt
P2860
P304
P356
10.1523/JNEUROSCI.4636-13.2014
P407
P577
2014-01-01T00:00:00Z