The Sonic Hedgehog pathway stimulates prostate tumor growth by paracrine signaling and recapitulates embryonic gene expression in tumor myofibroblasts
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Hedgehog Cholesterolysis: Specialized Gatekeeper to Oncogenic SignalingThe wound healing, chronic fibrosis, and cancer progression triadHedgehog Proteins Consume Steroidal CYP17A1 Antagonists: Potential Therapeutic Significance in Advanced Prostate CancerTranscriptional activation by NFκB increases perlecan/HSPG2 expression in the desmoplastic prostate tumor microenvironmentRole of the adjacent stroma cells in prostate cancer development and progression: synergy between TGF-β and IGF signaling.New promising drug targets in cancer- and metastasis-initiating cells.Molecular genetics of prostate cancer: new prospects for old challengesFrequent deregulations in the hedgehog signaling network and cross-talks with the epidermal growth factor receptor pathway involved in cancer progression and targeted therapies.Hedgehog overexpression leads to the formation of prostate cancer stem cells with metastatic property irrespective of androgen receptor expression in the mouse modelLKB1 inhibits breast cancer partially through repressing the Hedgehog signaling pathway.The hedgehog/Gli signaling paradigm in prostate cancerHedgehog signaling in prostate epithelial-mesenchymal growth regulation.Crosstalk between Desmoglein 2 and Patched 1 accelerates chemical-induced skin tumorigenesis.Osteoblast-secreted collagen upregulates paracrine Sonic hedgehog signaling by prostate cancer cells and enhances osteoblast differentiation.Association between Adult Height and Risk of Colorectal, Lung, and Prostate Cancer: Results from Meta-analyses of Prospective Studies and Mendelian Randomization Analyses.Glucocorticoid compounds modify smoothened localization and hedgehog pathway activityExpression of hedgehog pathway components in prostate carcinoma microenvironment: shifting the balance towards autocrine signallingA negative selection methodology using a microfluidic platform for the isolation and enumeration of circulating tumor cellsStromal hedgehog signaling maintains smooth muscle and hampers micro-invasive prostate cancer.Genes upregulated in prostate cancer reactive stroma promote prostate cancer progression in vivo.Non-cell-autonomous signaling by Shh in tumors: challenges and opportunities for therapeutic targets.Wnt and SHH in prostate cancer: trouble mongers occupy the TRAIL towards apoptosis.Crosstalk between TGF-β and hedgehog signaling in cancer.New prospects for drug development: the hedgehog pathway revealed. Focus on hematologic malignancies.Targeting of the Hedgehog pathway in myeloid malignancies: still a worthy chase?LKB1 suppresses proliferation and invasion of prostate cancer through hedgehog signaling pathway.Hedgehog signaling in myofibroblasts directly promotes prostate tumor cell growth.TAK-441, a novel investigational smoothened antagonist, delays castration-resistant progression in prostate cancer by disrupting paracrine hedgehog signaling.Androgens regulate Hedgehog signalling and proliferation in androgen-dependent prostate cells.Phosphodiesterase 4D inhibitors limit prostate cancer growth potential.Immunolocalization of glioma-associated oncogene homolog 1 in non melanoma skin cancer.Hedgehog-mesenchyme gene signature identifies bi-modal prognosis in luminal and basal breast cancer sub-types.Exploration of Shh and BMP paracrine signaling in a prostate cancer xenograft.Differential stage-dependent regulation of prostatic epithelial morphogenesis by Hedgehog signaling.Paracrine Hedgehog increases the steroidogenic potential of prostate stromal cells in a Gli-dependent manner.Retinoic acid, CYP26, and drug resistance in the stem cell niche.Expression of hedgehog signaling molecules as a prognostic indicator of oral squamous cell carcinoma.Hedgehog signaling is active in human prostate cancer stroma and regulates proliferation and differentiation of adjacent epithelium.Calcium and Nuclear Signaling in Prostate Cancer.
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The Sonic Hedgehog pathway stimulates prostate tumor growth by paracrine signaling and recapitulates embryonic gene expression in tumor myofibroblasts
description
article científic
@ca
article scientifique
@fr
articolo scientifico
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artigo científico
@pt
bilimsel makale
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scientific article published on 28 September 2009
@en
vedecký článok
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vetenskaplig artikel
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videnskabelig artikel
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vědecký článek
@cs
name
The Sonic Hedgehog pathway sti ...... ession in tumor myofibroblasts
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The Sonic Hedgehog pathway sti ...... ssion in tumor myofibroblasts.
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type
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The Sonic Hedgehog pathway sti ...... ession in tumor myofibroblasts
@en
The Sonic Hedgehog pathway sti ...... ssion in tumor myofibroblasts.
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prefLabel
The Sonic Hedgehog pathway sti ...... ession in tumor myofibroblasts
@en
The Sonic Hedgehog pathway sti ...... ssion in tumor myofibroblasts.
@nl
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P2860
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The Sonic Hedgehog pathway sti ...... ession in tumor myofibroblasts
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10.1038/ONC.2009.294
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P577
2009-09-28T00:00:00Z
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P6179
1038460190