Prospects for total synthesis: a vision for a totally synthetic vaccine targeting epithelial tumors.
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Strategy for Designing a Synthetic Tumor Vaccine: Multi-Component, Multivalency and Antigen ModificationEfficient chemoenzymatic synthesis of biotinylated human serum albumin-sialoglycoside conjugates containing O-acetylated sialic acids.Resolving conflicting data on expression of the Tn antigen and implications for clinical trials with cancer vaccinesFrom synthesis to biologics: preclinical data on a chemistry derived anticancer vaccineLinear and branched glyco-lipopeptide vaccines follow distinct cross-presentation pathways and generate different magnitudes of antitumor immunityA program for ligation at threonine sites: application to the controlled total synthesis of glycopeptides.A practical total synthesis of globo-H for use in anticancer vaccines.The immunomodulating roles of glycoproteins in epithelial ovarian cancer.Direct targeted glycation of the free sulfhydryl group of cysteine residue (Cys-34) of BSA. Mapping of the glycation sites of the anti-tumor Thomsen-Friedenreich neoglycoconjugate vaccine prepared by Michael addition reaction.Carbohydrate vaccines as immunotherapy for cancer.Synthetic carbohydrate-based antitumor vaccines: challenges and opportunities.Effects of hapten density on the induced antibody repertoireGlycan array analysis of the antigen repertoire targeted by tumor-binding antibodiesCarbohydrate based vaccines.Scalable synthesis of Fmoc-protected GalNAc-threonine amino acid and T(N) antigen via nickel catalysis.Onco-Golgi: Is Fragmentation a Gate to Cancer Progression?Clustered carbohydrates in synthetic vaccines.Biologics through chemistry: total synthesis of a proposed dual-acting vaccine targeting ovarian cancer by orchestration of oligosaccharide and polypeptide domains.On the emerging role of chemistry in the fashioning of biologics: synthesis of a bidomainal fucosyl GM1-based vaccine for the treatment of small cell lung cancer.A new model for the presentation of tumor-associated antigens and the quest for an anticancer vaccine: a solution to the synthesis challenge via ring-closing metathesis.Carbohydrate vaccines: developing sweet solutions to sticky situations?Immunotherapy for cancer: synthetic carbohydrate-based vaccines.Recent development in carbohydrate-based cancer vaccines.Synthetic carbohydrate-based anticancer vaccines: the Memorial Sloan-Kettering experience.Carbohydrate-based vaccines: challenges and opportunities.Recent advances in developing synthetic carbohydrate-based vaccines for cancer immunotherapies.Carbohydrate-based cancer vaccines: target cancer with sugar bullets.Multivalency in heterogeneous glycoenvironments: hetero-glycoclusters, -glycopolymers and -glycoassemblies.Cyclopeptide scaffolds in carbohydrate-based synthetic vaccines.Blood brothers: carbohydrates in xenotransplantation and cancer immunotherapy."Biologic" level structures through chemistry: A total synthesis of a unimolecular pentavalent MUCI glycopeptide construct.Synthesis of Biotinylated Tumor-Associated Carbohydrate Antigens for Immunological Studies.Orthogonal dual thiol-chloroacetyl and thiol-ene couplings for the sequential one-pot assembly of heteroglycoclustersImmune response to Thomsen-Friedenreich disaccharide and glycan engineering.Versatile fluorescent derivatization of glycans for glycomic analysis.Applying pose clustering and MD simulations to eliminate false positives in molecular docking.A multi-ligation strategy for the synthesis of heterofunctionalized glycosylated scaffolds.UDP-N-acetyl-D-galactosamine: polypeptide N-acetylgalactosaminyltransferase-6 as a new immunohistochemical breast cancer marker.
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Prospects for total synthesis: a vision for a totally synthetic vaccine targeting epithelial tumors.
description
article científic
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article scientifique
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articolo scientifico
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artigo científico
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bilimsel makale
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scientific article published on 27 July 2004
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vedecký článok
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vetenskaplig artikel
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videnskabelig artikel
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vědecký článek
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name
Prospects for total synthesis: ...... e targeting epithelial tumors.
@en
Prospects for total synthesis: ...... e targeting epithelial tumors.
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type
label
Prospects for total synthesis: ...... e targeting epithelial tumors.
@en
Prospects for total synthesis: ...... e targeting epithelial tumors.
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prefLabel
Prospects for total synthesis: ...... e targeting epithelial tumors.
@en
Prospects for total synthesis: ...... e targeting epithelial tumors.
@nl
P2860
P356
P1476
Prospects for total synthesis: ...... e targeting epithelial tumors.
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P2093
Samuel J Danishefsky
Stacy J Keding
P2860
P304
11937-11942
P356
10.1073/PNAS.0401894101
P407
P577
2004-07-27T00:00:00Z