Rescue treatment with a Rho-kinase inhibitor normalizes right ventricular function and reverses remodeling in juvenile rats with chronic pulmonary hypertension.
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Rho kinase proteins--pleiotropic modulators of cell survival and apoptosisProlonged vasoconstriction of resistance arteries involves vascular smooth muscle actin polymerization leading to inward remodellingRho kinase as a therapeutic target in cardiovascular disease.Improved pulmonary vascular reactivity and decreased hypertrophic remodeling during nonhypercapnic acidosis in experimental pulmonary hypertension.Effect of chronic perinatal hypoxia on the role of rho-kinase in pulmonary artery contraction in newborn lambs.Cross talk between autophagy and apoptosis in pulmonary hypertension.Rho kinases in cardiovascular physiology and pathophysiology: the effect of fasudil.Rho-kinase inhibitor Y-27632 attenuates pulmonary hypertension in hyperoxia-exposed newborn rats.Targeting RhoA/ROCK pathway in pulmonary arterial hypertension.mTOR-Notch3 signaling mediates pulmonary hypertension in hypoxia-exposed neonatal rats independent of changes in autophagy.Enhanced NO-dependent pulmonary vasodilation limits increased vasoconstrictor sensitivity in neonatal chronic hypoxia.Rho kinase mediates right ventricular systolic dysfunction in rats with chronic neonatal pulmonary hypertension.Beneficial effect of dehydroepiandrosterone on pulmonary hypertension in a rodent model of pulmonary hypertension in infants.Adverse biventricular remodeling in isolated right ventricular hypertension is mediated by increased transforming growth factor-β1 signaling and is abrogated by angiotensin receptor blockade.Role of the RhoA/ROCK pathway in high-altitude associated neonatal pulmonary hypertension in lambs.Moving beyond the "Allegory of the Cave" in the assessment of pulmonary arterial hypertension.Simvastatin prevents and reverses chronic pulmonary hypertension in newborn rats via pleiotropic inhibition of RhoA signaling.Endothelin-1-induced hypertrophic alterations and heme oxygenase-1 expression in cardiomyoblasts are counteracted by beta estradiol: in vitro and in vivo studies.Hypoxia induces pulmonary arterial fibroblast proliferation, migration, differentiation and vascular remodeling via the PI3K/Akt/p70S6K signaling pathway.Rho kinase and Na+ /H+ exchanger mediate endothelin-1-induced pulmonary arterial smooth muscle cell proliferation and migration.The level of ROCK1 and ROCK2 in patients with pulmonary hypertension in plateau area.Sustained therapeutic hypercapnia attenuates pulmonary arterial Rho-kinase activity and ameliorates chronic hypoxic pulmonary hypertension in juvenile rats
P2860
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P2860
Rescue treatment with a Rho-kinase inhibitor normalizes right ventricular function and reverses remodeling in juvenile rats with chronic pulmonary hypertension.
description
article científic
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article scientifique
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articolo scientifico
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artigo científico
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bilimsel makale
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scientific article published on October 2010
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vedecký článok
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vetenskaplig artikel
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videnskabelig artikel
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vědecký článek
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name
Rescue treatment with a Rho-ki ...... hronic pulmonary hypertension.
@en
Rescue treatment with a Rho-ki ...... hronic pulmonary hypertension.
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type
label
Rescue treatment with a Rho-ki ...... hronic pulmonary hypertension.
@en
Rescue treatment with a Rho-ki ...... hronic pulmonary hypertension.
@nl
prefLabel
Rescue treatment with a Rho-ki ...... hronic pulmonary hypertension.
@en
Rescue treatment with a Rho-ki ...... hronic pulmonary hypertension.
@nl
P2093
P2860
P1476
Rescue treatment with a Rho-ki ...... hronic pulmonary hypertension.
@en
P2093
Brian P Kavanagh
Crystal Kantores
Doreen Engelberts
Emily Z Xu
Julijana Ivanovska
Robert P Jankov
P2860
P304
P356
10.1152/AJPHEART.00595.2010
P577
2010-10-01T00:00:00Z