Inhibition of RhoA/Rho kinase pathway is involved in the beneficial effect of sildenafil on pulmonary hypertension - Wikidata - wikimedia - TriplyDB

Inhibition of RhoA/Rho kinase pathway is involved in the beneficial effect of sildenafil on pulmonary hypertension

Inhibition of RhoA/Rho kinase pathway is involved in the beneficial effect of sildenafil on pulmonary hypertension

http://www.wikidata.org/entity/Q28566149

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Deficiency of the NHE1 gene prevents hypoxia-induced pulmonary hypertension and vascular remodeling Nitric oxide-induced biphasic mechanism of vascular relaxation via dephosphorylation of CPI-17 and MYPT1 Molecular mechanism of telokin-mediated disinhibition of myosin light chain phosphatase and cAMP/cGMP-induced relaxation of gastrointestinal smooth muscle.Sildenafil inhibits chronically hypoxic upregulation of canonical transient receptor potential expression in rat pulmonary arterial smooth muscle miR-21/DDAH1 pathway regulates pulmonary vascular responses to hypoxia.Phosphorylation-dependent autoinhibition of myosin light chain phosphatase accounts for Ca2+ sensitization force of smooth muscle contraction The Rho/Rac exchange factor Vav2 controls nitric oxide-dependent responses in mouse vascular smooth muscle cells.PKG-1α leucine zipper domain defect increases pulmonary vascular tone: implications in hypoxic pulmonary hypertension.RhoA/Rho-kinase and vascular diseases: what is the link?Combination of sildenafil and simvastatin ameliorates monocrotaline-induced pulmonary hypertension in rats.Mitigation of the progression of heart failure with sildenafil involves inhibition of RhoA/Rho-kinase pathway The role of phosphodiesterase inhibitors in the management of pulmonary vascular diseases Endothelin-1 contributes to increased NFATc3 activation by chronic hypoxia in pulmonary arteries.Pleiotropic effects of statins in distal human pulmonary artery smooth muscle cells Dehydroepiandrosterone upregulates soluble guanylate cyclase and inhibits hypoxic pulmonary hypertension.Improved pulmonary vascular reactivity and decreased hypertrophic remodeling during nonhypercapnic acidosis in experimental pulmonary hypertension.Phosphodiesterase type 5 inhibitors: back and forward from cardiac indications Vascular remodeling in pulmonary hypertension.Involvement of RhoA/Rho kinase signaling in protection against monocrotaline-induced pulmonary hypertension in pneumonectomized rats by dehydroepiandrosterone.Emerging therapies for pulmonary arterial hypertension.Reactive oxygen species mediate RhoA/Rho kinase-induced Ca2+ sensitization in pulmonary vascular smooth muscle following chronic hypoxia.Therapeutic potential of RhoA/Rho kinase inhibitors in pulmonary hypertension Novel interactions between the 5-HT transporter, 5-HT1B receptors and Rho kinase in vivo and in pulmonary fibroblasts Fasudil inhibits the myogenic response in the fetal pulmonary circulation.Pulmonary hypertension: therapeutic targets within the serotonin system.MURC deficiency in smooth muscle attenuates pulmonary hypertension Signaling through Rho GTPase pathway as viable drug target.Therapeutic advances in pulmonary arterial hypertension.The pericyte: cellular regulator of microvascular blood flow Protective role of the antidiabetic drug metformin against chronic experimental pulmonary hypertension.Rescue treatment with a Rho-kinase inhibitor normalizes right ventricular function and reverses remodeling in juvenile rats with chronic pulmonary hypertension.Regulation of smooth muscle contraction by small GTPases.Sildenafil Can Affect Innate and Adaptive Immune System in Both Experimental Animals and Patients.Regulation of the pulmonary circulation in the fetus and newborn.Targeting RhoA/ROCK pathway in pulmonary arterial hypertension.Novel investigational therapies for treating pulmonary arterial hypertension.Protein kinase G signaling in cardiac pathophysiology: Impact of proteomics on clinical trials.Lung Circulation.Heparin inhibits pulmonary artery smooth muscle cell proliferation through guanine nucleotide exchange factor-H1/RhoA/Rho kinase/p27.Role of RhoB in the regulation of pulmonary endothelial and smooth muscle cell responses to hypoxia

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P2860

Inhibition of RhoA/Rho kinase pathway is involved in the beneficial effect of sildenafil on pulmonary hypertension

http://www.wikidata.org/entity/Q28566149

description

2005 թուականի Դեկտեմբերին հրատարակուած գիտական յօդուած

@hyw

2005 թվականի դեկտեմբերին հրատարակված գիտական հոդված

@hy

artículu científicu espublizáu en 2005

@ast

im Dezember 2005 veröffentlichter wissenschaftlicher Artikel

@de

scientific journal article

@en

vedecký článok (publikovaný 2005/12/01)

@sk

vědecký článek publikovaný v roce 2005

@cs

wetenschappelijk artikel (gepubliceerd op 2005/12/01)

@nl

наукова стаття, опублікована в грудні 2005

@uk

مقالة علمية (نشرت في ديسمبر 2005)

@ar

name

Inhibition of RhoA/Rho kinase ...... afil on pulmonary hypertension

@ast

Inhibition of RhoA/Rho kinase ...... afil on pulmonary hypertension

@en

Inhibition of RhoA/Rho kinase ...... afil on pulmonary hypertension

@nl

type

label

Inhibition of RhoA/Rho kinase ...... afil on pulmonary hypertension

@ast

Inhibition of RhoA/Rho kinase ...... afil on pulmonary hypertension

@en

Inhibition of RhoA/Rho kinase ...... afil on pulmonary hypertension

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prefLabel

Inhibition of RhoA/Rho kinase ...... afil on pulmonary hypertension

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Inhibition of RhoA/Rho kinase ...... afil on pulmonary hypertension

@en

Inhibition of RhoA/Rho kinase ...... afil on pulmonary hypertension

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British Journal of Pharmacology

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Inhibition of RhoA/Rho kinase ...... afil on pulmonary hypertension

@en

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Christine Sagan

http://www.w3.org/2001/XMLSchema#string

Malvyne Rolli-Derkinderen

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Patrice Guérin

http://www.w3.org/2001/XMLSchema#string

Pierre Pacaud

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Vincent Sauzeau

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P2860

Pleiotropic effects of statins

Inhibitory phosphorylation site for Rho-associated kinase on smooth muscle myosin phosphatase

Cyclic GMP-dependent protein kinase signaling pathway inhibits RhoA-induced Ca2+ sensitization of contraction in vascular smooth muscle

Rho-kinase mediates hypoxia-induced downregulation of endothelial nitric oxide synthase

Phosphorylation states of Cdc42 and RhoA regulate their interactions with Rho GDP dissociation inhibitor and their extraction from biological membranes

Increased expression of the cGMP-inhibited cAMP-specific (PDE3) and cGMP binding cGMP-specific (PDE5) phosphodiesterases in models of pulmonary hypertension

Rho GTPases and signaling networks

Ca2+ sensitivity of smooth muscle and nonmuscle myosin II: modulated by G proteins, kinases, and myosin phosphatase

Regulation of the small GTP-binding protein Rho by cell adhesion and the cytoskeleton

Signal transduction by G-proteins, rho-kinase and protein phosphatase to smooth muscle and non-muscle myosin II.

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1010-1018

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scholarly article

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3966418

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10.1038/SJ.BJP.0706408

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7

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146

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Christophe Guilluy

Gervaise Loirand

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2005-12-01T00:00:00Z

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7559176

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16205723

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arterial hypertension

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1751229

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