Heme triggers TLR4 signaling leading to endothelial cell activation and vaso-occlusion in murine sickle cell disease. - Wikidata - wikimedia - TriplyDB

Heme triggers TLR4 signaling leading to endothelial cell activation and vaso-occlusion in murine sickle cell disease.

Heme triggers TLR4 signaling leading to endothelial cell activation and vaso-occlusion in murine sickle cell disease.

http://www.wikidata.org/entity/Q37489028

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Magnesium for treating sickle cell disease Hemopexin and haptoglobin: allies against heme toxicity from hemoglobin not contenders Oxidative stress in preeclampsia and the role of free fetal hemoglobin Sickle cell disease biochip: a functional red blood cell adhesion assay for monitoring sickle cell disease.The fucosylation inhibitor, 2-fluorofucose, inhibits vaso-occlusion, leukocyte-endothelium interactions and NF-ĸB activation in transgenic sickle mice Morphine for the treatment of pain in sickle cell disease Advances in sickle cell therapies in the hydroxyurea era Haptoglobin, hemopexin, and related defense pathways-basic science, clinical perspectives, and drug development Protein aggregation as a cellular response to oxidative stress induced by heme and iron Sickle Cells Abolish Melanoma Tumorigenesis in Hemoglobin SS Knockin Mice and Augment the Tumoricidal Effect of Oncolytic Virus In Vivo Bartonella quintana lipopolysaccharide (LPS): structure and characteristics of a potent TLR4 antagonist for in-vitro and in-vivo applications Magnesium for treating sickle cell disease Quantitative intravital two-photon excitation microscopy reveals absence of pulmonary vaso-occlusion in unchallenged Sickle Cell Disease mice.Lung vaso-occlusion in sickle cell disease mediated by arteriolar neutrophil-platelet microemboli.Heme-mediated cell activation: the inflammatory puzzle of sickle cell anemia.Rapidly progressive acute chest syndrome in individuals with sickle cell anemia: a distinct acute chest syndrome phenotype.Atherogenesis and iron: from epidemiology to cellular level.Tissue factor-dependent coagulation activation by heme: A thromboelastometry study.Immunoregulatory networks in sickle cell alloimmunization.Impact of heme on specific antibody production in mice: promotive, inhibitive or null outcome is determined by its concentration.Disulfide high mobility group box-1 causes bladder pain through bladder Toll-like receptor 4.Heme-induced neutrophil extracellular traps contribute to the pathogenesis of sickle cell disease.Low-dose methotrexate in sickle-cell disease: a pilot study with rationale borrowed from rheumatoid arthritis.Redox properties of human hemoglobin in complex with fractionated dimeric and polymeric human haptoglobin Hemolysis-induced lethality involves inflammasome activation by heme Complement System Part I - Molecular Mechanisms of Activation and Regulation.Characterization of heme binding to recombinant α1-microglobulin.Sickle cell disease increases high mobility group box 1: a novel mechanism of inflammation.Iron, inflammation, and early death in adults with sickle cell disease.Vasculopathy and pulmonary hypertension in sickle cell disease.Role of heme in cardiovascular physiology and disease.Prevalence and gene characteristics of antibodies with cofactor-induced HIV-1 specificity.Dissection of the radical reactions linked to fetal hemoglobin reveals enhanced pseudoperoxidase activity.Haptoglobin attenuates hemoglobin-induced heme oxygenase-1 in renal proximal tubule cells and kidneys of a mouse model of sickle cell disease.Excess of heme induces tissue factor-dependent activation of coagulation in mice.Hemoglobin-induced lung vascular oxidation, inflammation, and remodeling contribute to the progression of hypoxic pulmonary hypertension and is attenuated in rats with repeated-dose haptoglobin administration.Methemoglobin is an endogenous toll-like receptor 4 ligand-relevance to subarachnoid hemorrhage.Blood substitutes: why haven't we been more successful?Circulating cell membrane microparticles transfer heme to endothelial cells and trigger vasoocclusions in sickle cell disease.Heme-Mediated Induction of CXCL10 and Depletion of CD34+ Progenitor Cells Is Toll-Like Receptor 4 Dependent

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Heme triggers TLR4 signaling leading to endothelial cell activation and vaso-occlusion in murine sickle cell disease.

http://www.wikidata.org/entity/Q37489028

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2013 nî lūn-bûn

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Heme triggers TLR4 signaling l ...... in murine sickle cell disease.

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Heme triggers TLR4 signaling l ...... in murine sickle cell disease.

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Heme triggers TLR4 signaling l ...... in murine sickle cell disease.

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Heme triggers TLR4 signaling l ...... in murine sickle cell disease.

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Heme triggers TLR4 signaling l ...... in murine sickle cell disease.

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Heme triggers TLR4 signaling l ...... in murine sickle cell disease.

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Abdu I Alayash

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Ann Smith

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Chunsheng Chen

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Fuad Abdulla

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Gregory M Vercellotti

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John D Belcher

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Julia Nguyen

http://www.w3.org/2001/XMLSchema#string

Karl A Nath

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Liming Milbauer

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Robert P Hebbel

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P2860

Cutting edge: direct interaction of TLR4 with NAD(P)H oxidase 4 isozyme is essential for lipopolysaccharide-induced production of reactive oxygen species and activation of NF-kappa B

A central role for free heme in the pathogenesis of severe sepsis

Haem transport to the liver by haemopexin. Receptor-mediated uptake with recycling of the protein

Primary role for adherent leukocytes in sickle cell vascular occlusion: a new paradigm

The rate of hemolysis in sickle cell disease correlates with the quantity of active von Willebrand factor in the plasma.

Heme degradation and vascular injury.

The HDAC inhibitors trichostatin A and suberoylanilide hydroxamic acid exhibit multiple modalities of benefit for the vascular pathobiology of sickle transgenic mice.

Identification of the haemoglobin scavenger receptor.

Pain-related behaviors and neurochemical alterations in mice expressing sickle hemoglobin: modulation by cannabinoids.

Hemolysis-associated endothelial dysfunction mediated by accelerated NO inactivation by decompartmentalized oxyhemoglobin.

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10.1182/BLOOD-2013-04-495887

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258923373

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24277079

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sickle-cell disease

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3894494

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