Heme triggers TLR4 signaling leading to endothelial cell activation and vaso-occlusion in murine sickle cell disease.
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Magnesium for treating sickle cell diseaseHemopexin and haptoglobin: allies against heme toxicity from hemoglobin not contendersOxidative stress in preeclampsia and the role of free fetal hemoglobinSickle cell disease biochip: a functional red blood cell adhesion assay for monitoring sickle cell disease.The fucosylation inhibitor, 2-fluorofucose, inhibits vaso-occlusion, leukocyte-endothelium interactions and NF-ĸB activation in transgenic sickle miceMorphine for the treatment of pain in sickle cell diseaseAdvances in sickle cell therapies in the hydroxyurea eraHaptoglobin, hemopexin, and related defense pathways-basic science, clinical perspectives, and drug developmentProtein aggregation as a cellular response to oxidative stress induced by heme and ironSickle Cells Abolish Melanoma Tumorigenesis in Hemoglobin SS Knockin Mice and Augment the Tumoricidal Effect of Oncolytic Virus In VivoBartonella quintana lipopolysaccharide (LPS): structure and characteristics of a potent TLR4 antagonist for in-vitro and in-vivo applicationsMagnesium for treating sickle cell diseaseQuantitative intravital two-photon excitation microscopy reveals absence of pulmonary vaso-occlusion in unchallenged Sickle Cell Disease mice.Lung vaso-occlusion in sickle cell disease mediated by arteriolar neutrophil-platelet microemboli.Heme-mediated cell activation: the inflammatory puzzle of sickle cell anemia.Rapidly progressive acute chest syndrome in individuals with sickle cell anemia: a distinct acute chest syndrome phenotype.Atherogenesis and iron: from epidemiology to cellular level.Tissue factor-dependent coagulation activation by heme: A thromboelastometry study.Immunoregulatory networks in sickle cell alloimmunization.Impact of heme on specific antibody production in mice: promotive, inhibitive or null outcome is determined by its concentration.Disulfide high mobility group box-1 causes bladder pain through bladder Toll-like receptor 4.Heme-induced neutrophil extracellular traps contribute to the pathogenesis of sickle cell disease.Low-dose methotrexate in sickle-cell disease: a pilot study with rationale borrowed from rheumatoid arthritis.Redox properties of human hemoglobin in complex with fractionated dimeric and polymeric human haptoglobinHemolysis-induced lethality involves inflammasome activation by hemeComplement System Part I - Molecular Mechanisms of Activation and Regulation.Characterization of heme binding to recombinant α1-microglobulin.Sickle cell disease increases high mobility group box 1: a novel mechanism of inflammation.Iron, inflammation, and early death in adults with sickle cell disease.Vasculopathy and pulmonary hypertension in sickle cell disease.Role of heme in cardiovascular physiology and disease.Prevalence and gene characteristics of antibodies with cofactor-induced HIV-1 specificity.Dissection of the radical reactions linked to fetal hemoglobin reveals enhanced pseudoperoxidase activity.Haptoglobin attenuates hemoglobin-induced heme oxygenase-1 in renal proximal tubule cells and kidneys of a mouse model of sickle cell disease.Excess of heme induces tissue factor-dependent activation of coagulation in mice.Hemoglobin-induced lung vascular oxidation, inflammation, and remodeling contribute to the progression of hypoxic pulmonary hypertension and is attenuated in rats with repeated-dose haptoglobin administration.Methemoglobin is an endogenous toll-like receptor 4 ligand-relevance to subarachnoid hemorrhage.Blood substitutes: why haven't we been more successful?Circulating cell membrane microparticles transfer heme to endothelial cells and trigger vasoocclusions in sickle cell disease.Heme-Mediated Induction of CXCL10 and Depletion of CD34+ Progenitor Cells Is Toll-Like Receptor 4 Dependent
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P2860
Heme triggers TLR4 signaling leading to endothelial cell activation and vaso-occlusion in murine sickle cell disease.
description
2013 nî lūn-bûn
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name
Heme triggers TLR4 signaling l ...... in murine sickle cell disease.
@en
Heme triggers TLR4 signaling l ...... in murine sickle cell disease.
@nl
type
label
Heme triggers TLR4 signaling l ...... in murine sickle cell disease.
@en
Heme triggers TLR4 signaling l ...... in murine sickle cell disease.
@nl
prefLabel
Heme triggers TLR4 signaling l ...... in murine sickle cell disease.
@en
Heme triggers TLR4 signaling l ...... in murine sickle cell disease.
@nl
P2093
P2860
P921
P1433
P1476
Heme triggers TLR4 signaling l ...... in murine sickle cell disease.
@en
P2093
Abdu I Alayash
Chunsheng Chen
Fuad Abdulla
Gregory M Vercellotti
John D Belcher
Julia Nguyen
Karl A Nath
Liming Milbauer
Robert P Hebbel
P2860
P304
P356
10.1182/BLOOD-2013-04-495887
P407
P577
2013-11-25T00:00:00Z