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Application of mechanism-based CYP inhibition for predicting drug-drug interactions.

Application of mechanism-based CYP inhibition for predicting drug-drug interactions.

http://www.wikidata.org/entity/Q37494640

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Computational and in vitro studies on the inhibitory effects of herbal compounds on human cytochrome P450 1A2.Xyloketal B, a marine compound, acts on a network of molecular proteins and regulates the activity and expression of rat cytochrome P450 3a: a bioinformatic and animal study.Structure, function, regulation and polymorphism and the clinical significance of human cytochrome P450 1A2.Estimation of the binding modes with important human cytochrome P450 enzymes, drug interaction potential, pharmacokinetics, and hepatotoxicity of ginger components using molecular docking, computational, and pharmacokinetic modeling studies.Reductive metabolism of oxymatrine is catalyzed by microsomal CYP3A4.The generation, detection, and effects of reactive drug metabolites.Exploring concepts of in vitro time-dependent CYP inhibition assays.Impact of physiological, pathological and environmental factors on the expression and activity of human cytochrome P450 2D6 and implications in precision medicine.INDI: a computational framework for inferring drug interactions and their associated recommendations.CYP3A4-based drug-drug interaction: CYP3A4 substrates' pharmacokinetic properties and ketoconazole dose regimen effect.Improved Predictions of Drug-Drug Interactions Mediated by Time-Dependent Inhibition of CYP3A.

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Application of mechanism-based CYP inhibition for predicting drug-drug interactions.

http://www.wikidata.org/entity/Q37494640

description

article científic

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article scientifique

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articolo scientifico

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artigo científico

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bilimsel makale

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scientific article published on June 2009

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vedecký článok

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vetenskaplig artikel

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videnskabelig artikel

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vědecký článek

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name

Application of mechanism-based CYP inhibition for predicting drug-drug interactions.

@en

Application of mechanism-based CYP inhibition for predicting drug-drug interactions.

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type

label

Application of mechanism-based CYP inhibition for predicting drug-drug interactions.

@en

Application of mechanism-based CYP inhibition for predicting drug-drug interactions.

@nl

prefLabel

Application of mechanism-based CYP inhibition for predicting drug-drug interactions.

@en

Application of mechanism-based CYP inhibition for predicting drug-drug interactions.

@nl

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17425250902926099

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Expert Opinion on Drug Metabolism & Toxicology

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Application of mechanism-based CYP inhibition for predicting drug-drug interactions.

@en

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Shu-Feng Zhou

http://www.w3.org/2001/XMLSchema#string

Zhi-Wei Zhou

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P2860

Clinical importance of the cytochromes P450

Therapeutic drugs that behave as mechanism-based inhibitors of cytochrome P450 3A4

The utility of in vitro cytochrome P450 inhibition data in the prediction of drug-drug interactions.

Predicting in vivo drug interactions from in vitro drug discovery data.

Prediction of in vivo drug-drug interactions from in vitro data : factors affecting prototypic drug-drug interactions involving CYP2C9, CYP2D6 and CYP3A4.

Drug-drug interactions via mechanism-based cytochrome P450 inactivation: points to consider for risk assessment from in vitro data and clinical pharmacologic evaluation.

Application of CYP3A4 in vitro data to predict clinical drug-drug interactions; predictions of compounds as objects of interaction

Methods for predicting in vivo pharmacokinetics using data from in vitro assays.

Drug-drug interactions of new active substances: mibefradil example.

Pharmacokinetic-pharmacodynamic consequences and clinical relevance of cytochrome P450 3A4 inhibition.

P304

579-605

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scholarly article

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10.1517/17425250902926099

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6

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2009-06-01T00:00:00Z

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19466877

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