Telomestatin impairs glioma stem cell survival and growth through the disruption of telomeric G-quadruplex and inhibition of the proto-oncogene, c-Myb.
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Impairment of glioma stem cell survival and growth by a novel inhibitor for Survivin-Ran protein complexSerine/Threonine Kinase MLK4 Determines Mesenchymal Identity in Glioma Stem Cells in an NF-κB-dependent Manner.Multi-kinase inhibitor C1 triggers mitotic catastrophe of glioma stem cells mainly through MELK kinase inhibitionTelomere biology and translational research.PARP3 is a promoter of chromosomal rearrangements and limits G4 DNA.Targeting glioma stem cells in vivo by a G-quadruplex-stabilizing synthetic macrocyclic hexaoxazole.Tumor-specific activation of the C-JUN/MELK pathway regulates glioma stem cell growth in a p53-dependent manner.RHPS4 G-quadruplex ligand induces anti-proliferative effects in brain tumor cells.A small molecule inhibitor of Pot1 binding to telomeric DNA.Aromatic core extension in the series of N-cyclic bay-substituted perylene G-quadruplex ligands: increased telomere damage, antitumor activity, and strong selectivity for neoplastic over healthy cells.G-quadruplexes in viruses: function and potential therapeutic applications.Prospects on strategies for therapeutically targeting oncogenic regulatory factors by small-molecule agentsCrosstalk between glioma-initiating cells and endothelial cells drives tumor progression.EZH2 protects glioma stem cells from radiation-induced cell death in a MELK/FOXM1-dependent mannerGene expression profiling distinguishes proneural glioma stem cells from mesenchymal glioma stem cells.Cancer stem cells and chemoresistance: The smartest survives the raidLaminin alpha 2 enables glioblastoma stem cell growthMesenchymal glioma stem cells are maintained by activated glycolytic metabolism involving aldehyde dehydrogenase 1A3.MELK-dependent FOXM1 phosphorylation is essential for proliferation of glioma stem cells.G-quadruplex ligand-induced DNA damage response coupled with telomere dysfunction and replication stress in glioma stem cells.The dynamic character of the BCL2 promoter i-motif provides a mechanism for modulation of gene expression by compounds that bind selectively to the alternative DNA hairpin structure.G-quadruplexes as potential therapeutic targets for embryonal tumors.Detoxification of oxidative stress in glioma stem cells: mechanism, clinical relevance, and therapeutic development.G-quadruplex interacting small molecules and drugs: from bench toward bedside.Targeting unimolecular G-quadruplex nucleic acids: a new paradigm for the drug discovery?Human telomerase inhibitors from microbial source.Senescence from glioma stem cell differentiation promotes tumor growthMultidrug-resistant cancer cells and cancer stem cells hijack cellular systems to circumvent systemic therapies, can natural products reverse this?Kinome-wide shRNA screen identifies the receptor tyrosine kinase AXL as a key regulator for mesenchymal glioblastoma stem-like cells.On-Chip Clonal Analysis of Glioma-Stem-Cell Motility and Therapy Resistance.Proneural-mesenchymal transformation of glioma stem cells: do therapies cause evolution of target in glioblastoma?Strong therapeutic potential of γ-secretase inhibitor MRK003 for CD44-high and CD133-low glioblastoma initiating cells.
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Telomestatin impairs glioma stem cell survival and growth through the disruption of telomeric G-quadruplex and inhibition of the proto-oncogene, c-Myb.
description
article científic
@ca
article scientifique
@fr
articolo scientifico
@it
artigo científico
@pt
bilimsel makale
@tr
scientific article published on 09 January 2012
@en
vedecký článok
@sk
vetenskaplig artikel
@sv
videnskabelig artikel
@da
vědecký článek
@cs
name
Telomestatin impairs glioma st ...... of the proto-oncogene, c-Myb.
@en
Telomestatin impairs glioma st ...... of the proto-oncogene, c-Myb.
@nl
type
label
Telomestatin impairs glioma st ...... of the proto-oncogene, c-Myb.
@en
Telomestatin impairs glioma st ...... of the proto-oncogene, c-Myb.
@nl
prefLabel
Telomestatin impairs glioma st ...... of the proto-oncogene, c-Myb.
@en
Telomestatin impairs glioma st ...... of the proto-oncogene, c-Myb.
@nl
P2093
P2860
P50
P1476
Telomestatin impairs glioma st ...... n of the proto-oncogene, c-Myb
@en
P2093
Deepti Purohit
Habibe Demir
Ichiro Nakano
Kaushal Joshi
Sachiko Okabe
Sarmistha Mazumder
Takao Yamori
P2860
P304
P356
10.1158/1078-0432.CCR-11-1795
P407
P577
2012-01-09T00:00:00Z