ROR1 can interact with TCL1 and enhance leukemogenesis in Eμ-TCL1 transgenic mice. - Wikidata - wikimedia - TriplyDB

ROR1 can interact with TCL1 and enhance leukemogenesis in Eμ-TCL1 transgenic mice.

ROR1 can interact with TCL1 and enhance leukemogenesis in Eμ-TCL1 transgenic mice.

http://www.wikidata.org/entity/Q37495234

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TCL1 transgenic mouse model as a tool for the study of therapeutic targets and microenvironment in human B-cell chronic lymphocytic leukemia Pre-clinical Specificity and Safety of UC-961, a First-In-Class Monoclonal Antibody Targeting ROR1 Silencing of Receptor Tyrosine Kinase ROR1 Inhibits Tumor-Cell Proliferation via PI3K/AKT/mTOR Signaling Pathway in Lung Adenocarcinoma Wnt5a induces ROR1 to complex with HS1 to enhance migration of chronic lymphocytic leukemia cells.Cirmtuzumab inhibits Wnt5a-induced Rac1 activation in chronic lymphocytic leukemia treated with ibrutinib.Ovarian cancer stem cells express ROR1, which can be targeted for anti-cancer-stem-cell therapy.Tumor antigen ROR1 targeted drug delivery mediated selective leukemic but not normal B-cell cytotoxicity in chronic lymphocytic leukemia.Safety of targeting ROR1 in primates with chimeric antigen receptor-modified T cells.Spontaneous Immunity Against the Receptor Tyrosine Kinase ROR1 in Patients with Chronic Lymphocytic Leukemia.Autocrine Signaling by Wnt-5a Deregulates Chemotaxis of Leukemic Cells and Predicts Clinical Outcome in Chronic Lymphocytic Leukemia Wnt5a induces ROR1/ROR2 heterooligomerization to enhance leukemia chemotaxis and proliferation.High-level ROR1 associates with accelerated disease progression in chronic lymphocytic leukemia.Functional genomics for personalized cancer therapy.Chk1 inhibition significantly potentiates activity of nucleoside analogs in TP53-mutated B-lymphoid cells Factors involved in CLL pathogenesis and cell survival are disrupted by differentiation of CLL B-cells into antibody-secreting cells.The long journey of TCL1 transgenic mice: lessons learned in the last 15 years.Receptor tyrosine kinase-like orphan receptor 1: a novel target for cancer immunotherapy.Wnt5a induces ROR1 to associate with 14-3-3ζ for enhanced chemotaxis and proliferation of chronic lymphocytic leukemia cells.Receptor tyrosine kinases in carcinogenesis.Wnt signalling pathways in chronic lymphocytic leukaemia and B-cell lymphomas.Molecular genetics and targeted therapy of WNT-related human diseases (Review).The PI3K/AKT/mTOR pathway is involved in direct apoptosis of CLL cells induced by ROR1 monoclonal antibodies.MicroRNA dysregulation to identify therapeutic target combinations for chronic lymphocytic leukemia.Antitumor activity of a newly developed monoclonal antibody against ROR1 in ovarian cancer cells.Wnt5a induces ROR1 to recruit DOCK2 to activate Rac1/2 in chronic lymphocytic leukemia.Novel role of prostate apoptosis response-4 tumor suppressor in B-cell chronic lymphocytic leukemia.Analysis of ROR1 Protein Expression in Mice with Reconstituted Human Immune System Components.Maintenance and pharmacologic targeting of ROR1 protein levels via UHRF1 in t(1;19) pre-B-ALL.Cirmtuzumab inhibits ibrutinib-resistant, Wnt5a-induced Rac1 activation and proliferation in mantle cell lymphoma.T-Cell Leukemia/Lymphoma 1 (TCL1): An Oncogene Regulating Multiple Signaling Pathways

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ROR1 can interact with TCL1 and enhance leukemogenesis in Eμ-TCL1 transgenic mice.

http://www.wikidata.org/entity/Q37495234

description

article científic

@ca

article scientifique

@fr

articolo scientifico

@it

artigo científico

@pt

bilimsel makale

@tr

scientific article published on 30 December 2013

@en

vedecký článok

@sk

vetenskaplig artikel

@sv

videnskabelig artikel

@da

vědecký článek

@cs

name

ROR1 can interact with TCL1 and enhance leukemogenesis in Eμ-TCL1 transgenic mice.

@en

ROR1 can interact with TCL1 and enhance leukemogenesis in Eμ-TCL1 transgenic mice.

@nl

type

label

ROR1 can interact with TCL1 and enhance leukemogenesis in Eμ-TCL1 transgenic mice.

@en

ROR1 can interact with TCL1 and enhance leukemogenesis in Eμ-TCL1 transgenic mice.

@nl

prefLabel

ROR1 can interact with TCL1 and enhance leukemogenesis in Eμ-TCL1 transgenic mice.

@en

ROR1 can interact with TCL1 and enhance leukemogenesis in Eμ-TCL1 transgenic mice.

@nl

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PNAS.1308374111

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Proceedings of the National Academy of Sciences of the United States of America

P1476

ROR1 can interact with TCL1 and enhance leukemogenesis in Eμ-TCL1 transgenic mice.

@en

P2093

Bing Cui

http://www.w3.org/2001/XMLSchema#string

Emanuela M Ghia

http://www.w3.org/2001/XMLSchema#string

George F Widhopf

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Karen Messer

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Liguang Chen

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Steven P Briggs

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Thomas J Kipps

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Zhouxin Shen

http://www.w3.org/2001/XMLSchema#string

P2860

NKX2-1/TITF1/TTF-1-Induced ROR1 is required to sustain EGFR survival signaling in lung adenocarcinoma

Antisera induced by infusions of autologous Ad-CD154-leukemia B cells identify ROR1 as an oncofetal antigen and receptor for Wnt5a

Tcl1 enhances Akt kinase activity and mediates its nuclear translocation

The protooncogene TCL1 is an Akt kinase coactivator

Tcl1 expression in chronic lymphocytic leukemia is regulated by miR-29 and miR-181

TCL1 participates in early embryonic development and is overexpressed in human seminomas

Identification of Akt association and oligomerization domains of the Akt kinase coactivator TCL1

Subcellular localization of activated AKT in estrogen receptor- and progesterone receptor-expressing breast cancers: potential clinical implications

Human chronic lymphocytic leukemia modeled in mouse by targeted TCL1 expression

ROR1 is expressed in human breast cancer and associated with enhanced tumor-cell growth.

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793-798

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scholarly article

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10.1073/PNAS.1308374111

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2

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111

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Carlo Maria Croce

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2013-12-30T00:00:00Z

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259499722

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24379361

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3896194

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