Identification of an alternative ligand-binding pocket in the nuclear vitamin D receptor and its functional importance in 1alpha,25(OH)2-vitamin D3 signaling. - Wikidata - wikimedia - TriplyDB

Identification of an alternative ligand-binding pocket in the nuclear vitamin D receptor and its functional importance in 1alpha,25(OH)2-vitamin D3 signaling.

Identification of an alternative ligand-binding pocket in the nuclear vitamin D receptor and its functional importance in 1alpha,25(OH)2-vitamin D3 signaling.

http://www.wikidata.org/entity/Q37511791

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Evolutionary selection across the nuclear hormone receptor superfamily with a focus on the NR1I subfamily (vitamin D, pregnane X, and constitutive androstane receptors).The Aryl Hydrocarbon Receptor Relays Metabolic Signals to Promote Cellular Regeneration Pleiotropic Activities of Vitamin D Receptors - Adequate Activation for Multiple Health Outcomes Structural considerations of vitamin D signaling Identification of a potent synthetic FXR agonist with an unexpected mode of binding and activation Sulindac-Derived RXRα Modulators Inhibit Cancer Cell Growth by Binding to a Novel Site Identification of a new hormone-binding site on the surface of thyroid hormone receptor Molecular mechanisms for regulation of intestinal calcium absorption by vitamin D and other factors Hydrogen/deuterium exchange reveals distinct agonist/partial agonist receptor dynamics within vitamin D receptor/retinoid X receptor heterodimer On the mechanism underlying (23S)-25-dehydro-1alpha(OH)-vitamin D3-26,23-lactone antagonism of hVDRwt gene activation and its switch to a superagonist.Estrogenic compounds, estrogen receptors and vascular cell signaling in the aging blood vessels Vitamin D and the intracrinology of innate immunity.Identification of novel immunoregulatory molecules in human thymic regulatory CD4+CD25+ T cells by phage display Lumisterol is metabolized by CYP11A1: discovery of a new pathway A second binding site for hydroxytamoxifen within the coactivator-binding groove of estrogen receptor beta.Vitamin D receptor (VDR) regulation of voltage-gated chloride channels by ligands preferring a VDR-alternative pocket (VDR-AP)The anti-cancer and anti-inflammatory actions of 1,25(OH)₂D₃ New insights into Vitamin D sterol-VDR proteolysis, allostery, structure-function from the perspective of a conformational ensemble model.The role of the vitamin D receptor and ERp57 in photoprotection by 1α,25-dihydroxyvitamin D3 Vitamin D resistance and colon cancer prevention.Functional evolution of the pregnane X receptor.Evolution and function of the NR1I nuclear hormone receptor subfamily (VDR, PXR, and CAR) with respect to metabolism of xenobiotics and endogenous compounds.High dietary vitamin D prevents hypocalcemia and osteomalacia in CYP27B1 knockout mice.Vitamin D and prevention of breast cancer.Novel vitamin D compounds and skin cancer prevention.Beyond the ligand-binding pocket: targeting alternate sites in nuclear receptors.Nongenotropic, anti-apoptotic signaling of 1alpha,25(OH)2-vitamin D3 and analogs through the ligand binding domain of the vitamin D receptor in osteoblasts and osteocytes. Mediation by Src, phosphatidylinositol 3-, and JNK kinases.An alternate binding site for PPARγ ligands Mineralization of three-dimensional osteoblast cultures is enhanced by the interaction of 1α,25-dihydroxyvitamin D3 and BMP2 via two specific vitamin D receptors.The role of vitamin D in the endocrinology controlling calcium homeostasis.Vitamin D receptor-dependent 1 alpha,25(OH)2 vitamin D3-induced anti-apoptotic PI3K/AKT signaling in osteoblasts The conformational dynamics of H2-H3n and S2-H6 in gating ligand entry into the buried binding cavity of vitamin D receptor.Correlation between secosteroid-induced vitamin D receptor activity in melanoma cells and computer-modeled receptor binding strength.A molecular description of ligand binding to the two overlapping binding pockets of the nuclear vitamin D receptor (VDR): structure-function implications.1alpha,25(OH)(2) vitamin D(3) induction of ATP secretion in osteoblasts.Dynamic changes in binding interaction networks of sex steroids establish their non-classical effects.Natural Anti-Estrogen Receptor Alpha Antibodies Able to Induce Estrogenic Responses in Breast Cancer Cells: Hypotheses Concerning Their Mechanisms of Action and Emergence.Vitamin D signaling and melanoma: role of vitamin D and its receptors in melanoma progression and management.Endogenously produced nonclassical vitamin D hydroxy-metabolites act as "biased" agonists on VDR and inverse agonists on RORα and RORγ.ERα dimerization: a key factor for the weak estrogenic activity of an ERα modulator unable to compete with estradiol in binding assays.

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Identification of an alternative ligand-binding pocket in the nuclear vitamin D receptor and its functional importance in 1alpha,25(OH)2-vitamin D3 signaling.

http://www.wikidata.org/entity/Q37511791

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article científic

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article scientifique

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articolo scientifico

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artigo científico

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bilimsel makale

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scientific article published on 23 August 2004

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vedecký článok

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vetenskaplig artikel

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vědecký článek

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name

Identification of an alternati ...... ,25(OH)2-vitamin D3 signaling.

@en

Identification of an alternati ...... ,25(OH)2-vitamin D3 signaling.

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type

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Identification of an alternati ...... ,25(OH)2-vitamin D3 signaling.

@en

Identification of an alternati ...... ,25(OH)2-vitamin D3 signaling.

@nl

prefLabel

Identification of an alternati ...... ,25(OH)2-vitamin D3 signaling.

@en

Identification of an alternati ...... ,25(OH)2-vitamin D3 signaling.

@nl

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PNAS.0403606101

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Proceedings of the National Academy of Sciences of the United States of America

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Identification of an alternati ...... ,25(OH)2-vitamin D3 signaling.

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Anthony W Norman

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Craig M Bula

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Dino Moras

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Don Keidel

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June E Bishop

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Laura P Zanello

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Mathew T Mizwicki

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P2860

The crystal structure of the nuclear receptor for vitamin D bound to its natural ligand

A structural basis for the unique binding features of the human vitamin D-binding protein

Crystal structure of the human RXRalpha ligand-binding domain bound to its natural ligand: 9-cis retinoic acid

Crystal structures of the vitamin D receptor complexed to superagonist 20-epi ligands

Ligand binding and co-activator assembly of the peroxisome proliferator-activated receptor-gamma

The nuclear receptor superfamily: the second decade

The rapid effects of 1,25-dihydroxyvitamin D3 require the vitamin D receptor and influence 24-hydroxylase activity: studies in human skin fibroblasts bearing vitamin D receptor mutations

Nongenotropic, sex-nonspecific signaling through the estrogen or androgen receptors: dissociation from transcriptional activity

Synthesis and NMR studies of (13)C-labeled vitamin D metabolites.

Rapid and genomic biological responses are mediated by different shapes of the agonist steroid hormone, 1alpha,25(OH)2vitamin D3.

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12876-12881

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scholarly article

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10.1073/PNAS.0403606101

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35

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Jean-Marie Wurtz

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2004-08-23T00:00:00Z

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