Identification of an alternative ligand-binding pocket in the nuclear vitamin D receptor and its functional importance in 1alpha,25(OH)2-vitamin D3 signaling.
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Evolutionary selection across the nuclear hormone receptor superfamily with a focus on the NR1I subfamily (vitamin D, pregnane X, and constitutive androstane receptors).The Aryl Hydrocarbon Receptor Relays Metabolic Signals to Promote Cellular RegenerationPleiotropic Activities of Vitamin D Receptors - Adequate Activation for Multiple Health OutcomesStructural considerations of vitamin D signalingIdentification of a potent synthetic FXR agonist with an unexpected mode of binding and activationSulindac-Derived RXRα Modulators Inhibit Cancer Cell Growth by Binding to a Novel SiteIdentification of a new hormone-binding site on the surface of thyroid hormone receptorMolecular mechanisms for regulation of intestinal calcium absorption by vitamin D and other factorsHydrogen/deuterium exchange reveals distinct agonist/partial agonist receptor dynamics within vitamin D receptor/retinoid X receptor heterodimerOn the mechanism underlying (23S)-25-dehydro-1alpha(OH)-vitamin D3-26,23-lactone antagonism of hVDRwt gene activation and its switch to a superagonist.Estrogenic compounds, estrogen receptors and vascular cell signaling in the aging blood vesselsVitamin D and the intracrinology of innate immunity.Identification of novel immunoregulatory molecules in human thymic regulatory CD4+CD25+ T cells by phage displayLumisterol is metabolized by CYP11A1: discovery of a new pathwayA second binding site for hydroxytamoxifen within the coactivator-binding groove of estrogen receptor beta.Vitamin D receptor (VDR) regulation of voltage-gated chloride channels by ligands preferring a VDR-alternative pocket (VDR-AP)The anti-cancer and anti-inflammatory actions of 1,25(OH)₂D₃New insights into Vitamin D sterol-VDR proteolysis, allostery, structure-function from the perspective of a conformational ensemble model.The role of the vitamin D receptor and ERp57 in photoprotection by 1α,25-dihydroxyvitamin D3Vitamin D resistance and colon cancer prevention.Functional evolution of the pregnane X receptor.Evolution and function of the NR1I nuclear hormone receptor subfamily (VDR, PXR, and CAR) with respect to metabolism of xenobiotics and endogenous compounds.High dietary vitamin D prevents hypocalcemia and osteomalacia in CYP27B1 knockout mice.Vitamin D and prevention of breast cancer.Novel vitamin D compounds and skin cancer prevention.Beyond the ligand-binding pocket: targeting alternate sites in nuclear receptors.Nongenotropic, anti-apoptotic signaling of 1alpha,25(OH)2-vitamin D3 and analogs through the ligand binding domain of the vitamin D receptor in osteoblasts and osteocytes. Mediation by Src, phosphatidylinositol 3-, and JNK kinases.An alternate binding site for PPARγ ligandsMineralization of three-dimensional osteoblast cultures is enhanced by the interaction of 1α,25-dihydroxyvitamin D3 and BMP2 via two specific vitamin D receptors.The role of vitamin D in the endocrinology controlling calcium homeostasis.Vitamin D receptor-dependent 1 alpha,25(OH)2 vitamin D3-induced anti-apoptotic PI3K/AKT signaling in osteoblastsThe conformational dynamics of H2-H3n and S2-H6 in gating ligand entry into the buried binding cavity of vitamin D receptor.Correlation between secosteroid-induced vitamin D receptor activity in melanoma cells and computer-modeled receptor binding strength.A molecular description of ligand binding to the two overlapping binding pockets of the nuclear vitamin D receptor (VDR): structure-function implications.1alpha,25(OH)(2) vitamin D(3) induction of ATP secretion in osteoblasts.Dynamic changes in binding interaction networks of sex steroids establish their non-classical effects.Natural Anti-Estrogen Receptor Alpha Antibodies Able to Induce Estrogenic Responses in Breast Cancer Cells: Hypotheses Concerning Their Mechanisms of Action and Emergence.Vitamin D signaling and melanoma: role of vitamin D and its receptors in melanoma progression and management.Endogenously produced nonclassical vitamin D hydroxy-metabolites act as "biased" agonists on VDR and inverse agonists on RORα and RORγ.ERα dimerization: a key factor for the weak estrogenic activity of an ERα modulator unable to compete with estradiol in binding assays.
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Identification of an alternative ligand-binding pocket in the nuclear vitamin D receptor and its functional importance in 1alpha,25(OH)2-vitamin D3 signaling.
description
article científic
@ca
article scientifique
@fr
articolo scientifico
@it
artigo científico
@pt
bilimsel makale
@tr
scientific article published on 23 August 2004
@en
vedecký článok
@sk
vetenskaplig artikel
@sv
videnskabelig artikel
@da
vědecký článek
@cs
name
Identification of an alternati ...... ,25(OH)2-vitamin D3 signaling.
@en
Identification of an alternati ...... ,25(OH)2-vitamin D3 signaling.
@nl
type
label
Identification of an alternati ...... ,25(OH)2-vitamin D3 signaling.
@en
Identification of an alternati ...... ,25(OH)2-vitamin D3 signaling.
@nl
prefLabel
Identification of an alternati ...... ,25(OH)2-vitamin D3 signaling.
@en
Identification of an alternati ...... ,25(OH)2-vitamin D3 signaling.
@nl
P2093
P2860
P921
P356
P1476
Identification of an alternati ...... ,25(OH)2-vitamin D3 signaling.
@en
P2093
Anthony W Norman
Craig M Bula
Dino Moras
Don Keidel
June E Bishop
Laura P Zanello
Mathew T Mizwicki
P2860
P304
12876-12881
P356
10.1073/PNAS.0403606101
P407
P577
2004-08-23T00:00:00Z