Targeting endoplasmic reticulum stress and Akt with OSU-03012 and gefitinib or erlotinib to overcome resistance to epidermal growth factor receptor inhibitors.
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Up-regulation of Mcl-1 and Bak by coronavirus infection of human, avian and animal cells modulates apoptosis and viral replicationGrowth inhibitory and anti-tumour activities of OSU-03012, a novel PDK-1 inhibitor, on vestibular schwannoma and malignant schwannoma cells.Eradication of intracellular Francisella tularensis in THP-1 human macrophages with a novel autophagy inducing agentQuantifying the sensitivities of EGF receptor (EGFR) tyrosine kinase inhibitors in drug resistant non-small cell lung cancer (NSCLC) cells using hydrogel-based peptide arrayNeedle-Free Delivery of Acetalated Dextran-Encapsulated AR-12 Protects Mice from Francisella tularensis Lethal Challenge.OSU-03012 sensitizes breast cancers to lapatinib-induced cell killing: a role for Nck1 but not Nck2.Eradication of intracellular Salmonella enterica serovar Typhimurium with a small-molecule, host cell-directed agentSynergistic effects of nelfinavir and bortezomib on proteotoxic death of NSCLC and multiple myeloma cellsGRP78/Dna K Is a Target for Nexavar/Stivarga/Votrient in the Treatment of Human Malignancies, Viral Infections and Bacterial Diseases.Matched miRNA and mRNA signatures from an hESC-based in vitro model of pancreatic differentiation reveal novel regulatory interactions.RAF1-MEK1-ERK/AKT axis may confer NSCLC cell lines resistance to erlotinibAntitumor mechanisms of targeting the PDK1 pathway in head and neck cancer.The PI3 kinase/mTOR blocker NVP-BEZ235 overrides resistance against irreversible ErbB inhibitors in breast cancer cells.Potassium as a pluripotency-associated element identified through inorganic element profiling in human pluripotent stem cells.The combination of antitumor drugs, exemestane and erlotinib, induced resistance mechanism in H358 and A549 non-small cell lung cancer (NSCLC) cell lines.Combination Strategies Using EGFR-TKi in NSCLC Therapy: Learning from the Gap between Pre-Clinical Results and Clinical Outcomes.Disrupting Y-Box-Binding Protein 1 Function Using OSU-03012 Prevents Endometriosis Progression in In Vitro and In Vivo Models.A Combination of Two Receptor Tyrosine Kinase Inhibitors, Canertinib and PHA665752 Compromises Ovarian Cancer Cell Growth in 3D Cell Models.Oligomycin A enhances apoptotic effect of TRAIL through CHOP-mediated death receptor 5 expression.
P2860
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P2860
Targeting endoplasmic reticulum stress and Akt with OSU-03012 and gefitinib or erlotinib to overcome resistance to epidermal growth factor receptor inhibitors.
description
article científic
@ca
article scientifique
@fr
articolo scientifico
@it
artigo científico
@pt
bilimsel makale
@tr
scientific article published on April 2008
@en
vedecký článok
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vetenskaplig artikel
@sv
videnskabelig artikel
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vědecký článek
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name
Targeting endoplasmic reticulu ...... th factor receptor inhibitors.
@en
Targeting endoplasmic reticulu ...... th factor receptor inhibitors.
@nl
type
label
Targeting endoplasmic reticulu ...... th factor receptor inhibitors.
@en
Targeting endoplasmic reticulu ...... th factor receptor inhibitors.
@nl
prefLabel
Targeting endoplasmic reticulu ...... th factor receptor inhibitors.
@en
Targeting endoplasmic reticulu ...... th factor receptor inhibitors.
@nl
P2093
P2860
P1433
P1476
Targeting endoplasmic reticulu ...... wth factor receptor inhibitors
@en
P2093
Aaron M Sargeant
Chih-Cheng Yang
Ching-Shih Chen
Dasheng Wang
Geen-Dong Chang
Mamoru Yamaguchi
Samuel K Kulp
Yoko Kashida
Yu-Chieh Wang
P2860
P304
P356
10.1158/0008-5472.CAN-07-1336
P407
P577
2008-04-01T00:00:00Z