Cyclin-dependent kinase 4 may be expressed as multiple proteins and have functions that are independent of binding to CCND and RB and occur at the S and G 2/M phases of the cell cycle.
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To Know How a Gene Works, We Need to Redefine It First but then, More Importantly, to Let the Cell Itself Decide How to Transcribe and Process Its RNAsThe other side of the coin: the tumor-suppressive aspect of oncogenes and the oncogenic aspect of tumor-suppressive genes, such as those along the CCND-CDK4/6-RB axisIt Is Imperative to Establish a Pellucid Definition of Chimeric RNA and to Clear Up a Lot of Confusion in the Relevant Research.Culture at a Higher Temperature Mildly Inhibits Cancer Cell Growth but Enhances Chemotherapeutic Effects by Inhibiting Cell-Cell Collaboration.Two RNAs or DNAs May Artificially Fuse Together at a Short Homologous Sequence (SHS) during Reverse Transcription or Polymerase Chain Reactions, and Thus Reporting an SHS-Containing Chimeric RNA Requires Extra Caution.JMJD3 promotes SAHF formation in senescent WI38 cells by triggering an interplay between demethylation and phosphorylation of RB protein.The helicase-like transcription factor (HLTF) in cancer: loss of function or oncomorphic conversion of a tumor suppressor?Direct repression of the oncogene CDK4 by the tumor suppressor miR-486-5p in non-small cell lung cancerIsoforms of wild type proteins often appear as low molecular weight bands on SDS-PAGE.Probably less than one-tenth of the genes produce only the wild type protein without at least one additional protein isoform in some human cancer cell lines.Down-regulation of POTEG predicts poor prognosis in esophageal squamous cell carcinoma patients.While it is not deliberate, much of today's biomedical research contains logical and technical flaws, showing a need for corrective action.
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Cyclin-dependent kinase 4 may be expressed as multiple proteins and have functions that are independent of binding to CCND and RB and occur at the S and G 2/M phases of the cell cycle.
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article científic
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article scientifique
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articolo scientifico
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artigo científico
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bilimsel makale
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scientific article published on 24 September 2013
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vedecký článok
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vetenskaplig artikel
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videnskabelig artikel
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vědecký článek
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name
Cyclin-dependent kinase 4 may ...... 2/M phases of the cell cycle.
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Cyclin-dependent kinase 4 may ...... 2/M phases of the cell cycle.
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type
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Cyclin-dependent kinase 4 may ...... 2/M phases of the cell cycle.
@en
Cyclin-dependent kinase 4 may ...... 2/M phases of the cell cycle.
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prefLabel
Cyclin-dependent kinase 4 may ...... 2/M phases of the cell cycle.
@en
Cyclin-dependent kinase 4 may ...... 2/M phases of the cell cycle.
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Cyclin-dependent kinase 4 may ...... 2/M phases of the cell cycle.
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Bing-Kun Xie
Chengfu Yuan
D Joshua Liao
Jian-Min Wu
Ningzhi Xu
Steven Xj Shen
Xiaomin Lou
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P304
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10.4161/CC.26510
P577
2013-09-24T00:00:00Z