Lenalidomide overcomes suppression of human natural killer cell anti-tumor functions by neuroblastoma microenvironment-associated IL-6 and TGFβ1. - Wikidata - wikimedia - TriplyDB

Lenalidomide overcomes suppression of human natural killer cell anti-tumor functions by neuroblastoma microenvironment-associated IL-6 and TGFβ1.

Lenalidomide overcomes suppression of human natural killer cell anti-tumor functions by neuroblastoma microenvironment-associated IL-6 and TGFβ1.

http://www.wikidata.org/entity/Q37535365

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Cancer Stem Cells and Their Interaction with the Tumor Microenvironment in Neuroblastoma Tumor macroenvironment and metabolism.Immune reconstitution from peripheral blood mononuclear cells inhibits lung carcinoma growth in NOD/SCID mice A think tank of TINK/TANKs: tumor-infiltrating/tumor-associated natural killer cells in tumor progression and angiogenesis.Gene-expression and in vitro function of mesenchymal stromal cells are affected in juvenile myelomonocytic leukemia Optimization of a Neural Stem-Cell-Mediated Carboxylesterase/Irinotecan Gene Therapy for Metastatic Neuroblastoma.New immunotherapeutic strategies for the treatment of neuroblastoma.More than the genes, the tumor microenvironment in neuroblastoma.Natural killer-like signature observed post therapy in locally advanced rectal cancer is a determinant of pathological response and improved survival.The mechanism of epithelial-mesenchymal transition induced by TGF-β1 in neuroblastoma cells A phase 1b study of isatuximab plus lenalidomide and dexamethasone for relapsed/refractory multiple myeloma.Involvement of IL-10 and TGF-β in HLA-E-mediated neuroblastoma migration and invasion.Lenalidomide augments actin remodeling and lowers NK-cell activation thresholds.TGFβR1 Blockade with Galunisertib (LY2157299) Enhances Anti-Neuroblastoma Activity of the Anti-GD2 Antibody Dinutuximab (ch14.18) with Natural Killer Cells.Lenalidomide overcomes the immunosuppression of regulatory CD8+CD28- T-cells.Anti-GD2 immunotherapy for neuroblastoma.The CXCR4-STAT3-IL-10 Pathway Controls the Immunoregulatory Function of Chronic Lymphocytic Leukemia and Is Modulated by Lenalidomide.Emerging and investigational therapies for neuroblastoma.Deficiencies in Natural Killer Cell Numbers, Expansion, and Function at the Pre-Neoplastic Stage of Pancreatic Cancer by KRAS Mutation in the Pancreas of Obese Mice.

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Lenalidomide overcomes suppression of human natural killer cell anti-tumor functions by neuroblastoma microenvironment-associated IL-6 and TGFβ1.

http://www.wikidata.org/entity/Q37535365

description

article científic

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article scientifique

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articolo scientifico

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artigo científico

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bilimsel makale

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scientific article published on 27 August 2013

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vedecký článok

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vetenskaplig artikel

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videnskabelig artikel

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vědecký článek

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name

Lenalidomide overcomes suppres ...... ent-associated IL-6 and TGFβ1.

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Lenalidomide overcomes suppres ...... ent-associated IL-6 and TGFβ1.

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Lenalidomide overcomes suppres ...... ent-associated IL-6 and TGFβ1.

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Lenalidomide overcomes suppres ...... ent-associated IL-6 and TGFβ1.

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Lenalidomide overcomes suppres ...... ent-associated IL-6 and TGFβ1.

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Lenalidomide overcomes suppres ...... ent-associated IL-6 and TGFβ1.

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S00262-013-1466-Y

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Cancer Immunology, Immunotherapy

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Lenalidomide overcomes suppres ...... ent-associated IL-6 and TGFβ1.

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Hong Wei Wu

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Hung C Tran

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Jianping Sun

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Michael A Sheard

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Richard Sposto

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Robert C Seeger

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Shahab Asgharzadeh

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Wei Yao Liu

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Yibing Xu

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Zesheng Wan

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P2860

Anti-GD2 antibody with GM-CSF, interleukin-2, and isotretinoin for neuroblastoma

TGF-beta utilizes SMAD3 to inhibit CD16-mediated IFN-gamma production and antibody-dependent cellular cytotoxicity in human NK cells

Safety, pharmacokinetics, and immunomodulatory effects of lenalidomide in children and adolescents with relapsed/refractory solid tumors or myelodysplastic syndrome: a Children's Oncology Group Phase I Consortium report.

Phase I trial of lenalidomide in pediatric patients with recurrent, refractory, or progressive primary CNS tumors: Pediatric Brain Tumor Consortium study PBTC-018.

TGF-β affects development and differentiation of human natural killer cell subsets

TGFbeta promotes conversion of CD16+ peripheral blood NK cells into CD16- NK cells with similarities to decidual NK cells.

Selective long-term elimination of natural killer cells in vivo by an anti-interleukin 2 receptor beta chain monoclonal antibody in mice

The biology of interleukin-2 and interleukin-15: implications for cancer therapy and vaccine design.

Phase I study to determine the safety, tolerability and immunostimulatory activity of thalidomide analogue CC-5013 in patients with metastatic malignant melanoma and other advanced cancers.

Clinical significance of tumor-associated inflammatory cells in metastatic neuroblastoma.

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s00262-013-1466-y

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1637-1648

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10.1007/S00262-013-1466-Y

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