Mutation of Pro-258 in transmembrane domain 6 constitutively activates the G protein-coupled alpha-factor receptor.
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Life history and developmental processes in the basidiomycete Coprinus cinereusA microdomain formed by the extracellular ends of the transmembrane domains promotes activation of the G protein-coupled alpha-factor receptorInternational Union of Basic and Clinical Pharmacology. LXXV. Nomenclature, classification, and pharmacology of G protein-coupled melatonin receptors.Structure and topology of a peptide segment of the 6th transmembrane domain of the Saccharomyces cerevisae alpha-factor receptor in phospholipid bilayersProline in α-helical kink is required for folding kinetics but not for kinked structure, function, or stability of heat shock transcription factorDominant-negative mutations in the G-protein-coupled alpha-factor receptor map to the extracellular ends of the transmembrane segments.High resolution NMR analysis of the seven transmembrane domains of a heptahelical receptor in organic-aqueous medium.Signaling of human frizzled receptors to the mating pathway in yeast.Systematic identification of mutations that constitutively activate the angiotensin II type 1A receptor by screening a randomly mutated cDNA library with an original pharmacological bioassayBiosynthesis and biophysical analysis of domains of a yeast G protein-coupled receptor.Residues in the first extracellular loop of a G protein-coupled receptor play a role in signal transduction.Random mutagenesis of the M3 muscarinic acetylcholine receptor expressed in yeast: identification of second-site mutations that restore function to a coupling-deficient mutant M3 receptor.Structure of segments of a G protein-coupled receptor: CD and NMR analysis of the Saccharomyces cerevisiae tridecapeptide pheromone receptor.Synthesis and biophysical characterization of a multidomain peptide from a Saccharomyces cerevisiae G protein-coupled receptor.Synthetic morphology using alternative inputs.Identification of residue-to-residue contact between a peptide ligand and its G protein-coupled receptor using periodate-mediated dihydroxyphenylalanine cross-linking and mass spectrometryIdentification of a polar region in transmembrane domain 6 that regulates the function of the G protein-coupled alpha-factor receptorIdentifying functionally important conformational changes in proteins: activation of the yeast α-factor receptor Ste2pOligomerization of G-protein-coupled receptors: lessons from the yeast Saccharomyces cerevisiae.Magnificent seven: roles of G protein-coupled receptors in extracellular sensing in fungi.Comparison of class A and D G protein-coupled receptors: common features in structure and activation.Dominant-negative activity of an alpha(1B)-adrenergic receptor signal-inactivating point mutation.The cytoplasmic end of transmembrane domain 3 regulates the activity of the Saccharomyces cerevisiae G-protein-coupled alpha-factor receptorIdentification of destabilizing and stabilizing mutations of Ste2p, a G protein-coupled receptor in Saccharomyces cerevisiae.Yeast Ste2 receptors as tools for study of mammalian protein kinases and adaptors involved in receptor trafficking.Signaling-sensitive amino acids surround the allosteric ligand binding site of the thyrotropin receptor.The seven-transmembrane receptor Gpr1 governs processes relevant for the antagonistic interaction of Trichoderma atroviride with its host.Accessibility of cysteine residues substituted into the cytoplasmic regions of the alpha-factor receptor identifies the intracellular residues that are available for G protein interaction.The role of the membrane-spanning domain sequence in glycoprotein-mediated membrane fusionQuantification of mutation-derived bias for alternate mating functionalities of the Saccharomyces cerevisiae Ste2p pheromone receptorAssessment of constitutive activity of a G protein-coupled receptor, CPR2, in Cryptococcus neoformans by heterologous and homologous methods.Strategies for isolating constitutively active and dominant-negative pheromone receptor mutants in yeastA constitutively active GPCR governs morphogenic transitions in Cryptococcus neoformansYeast GPCR signaling reflects the fraction of occupied receptors, not the numberParathyroid hormone-receptor interactions identified directly by photocross-linking and molecular modeling studies.Mechanisms governing the activation and trafficking of yeast G protein-coupled receptors.The C terminus of the Saccharomyces cerevisiae alpha-factor receptor contributes to the formation of preactivation complexes with its cognate G protein.Functional and physical interactions among Saccharomyces cerevisiae α-factor receptors.Differential interactions of fluorescent agonists and antagonists with the yeast G protein coupled receptor Ste2p.A constitutively active G-protein-coupled receptor causes mating self-compatibility in the mushroom Coprinus.
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P2860
Mutation of Pro-258 in transmembrane domain 6 constitutively activates the G protein-coupled alpha-factor receptor.
description
article científic
@ca
article scientifique
@fr
articolo scientifico
@it
artigo científico
@pt
bilimsel makale
@tr
scientific article published on June 1996
@en
vedecký článok
@sk
vetenskaplig artikel
@sv
videnskabelig artikel
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vědecký článek
@cs
name
Mutation of Pro-258 in transme ...... coupled alpha-factor receptor.
@en
Mutation of Pro-258 in transme ...... coupled alpha-factor receptor.
@nl
type
label
Mutation of Pro-258 in transme ...... coupled alpha-factor receptor.
@en
Mutation of Pro-258 in transme ...... coupled alpha-factor receptor.
@nl
prefLabel
Mutation of Pro-258 in transme ...... coupled alpha-factor receptor.
@en
Mutation of Pro-258 in transme ...... coupled alpha-factor receptor.
@nl
P2860
P356
P1476
Mutation of Pro-258 in transme ...... -coupled alpha-factor receptor
@en
P2093
P2860
P304
P356
10.1073/PNAS.93.13.6764
P407
P577
1996-06-01T00:00:00Z