LKB1 and AMPK family signaling: the intimate link between cell polarity and energy metabolism.
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STRAD pseudokinases regulate axogenesis and LKB1 stabilityThe AMPK signalling pathway coordinates cell growth, autophagy and metabolismAMPK as a potential anticancer target - friend or foe?Studying non-alcoholic fatty liver disease with zebrafish: a confluence of optics, genetics, and physiologyGSK-3 as potential target for therapeutic intervention in cancerExtracellular lumican inhibits pancreatic cancer cell growth and is associated with prolonged survival after surgeryAn insight into the transcriptome of the digestive tract of the bloodsucking bug, Rhodnius prolixusInvestigation of LKB1 Ser431 phosphorylation and Cys433 farnesylation using mouse knockin analysis reveals an unexpected role of prenylation in regulating AMPK activityAberrant intestinal stem cell lineage dynamics in Peutz-Jeghers syndrome and familial adenomatous polyposis consistent with protracted clonal evolution in the cryptLKB1 as the ghostwriter of crypt historyNoise-Induced Loss of Hair Cells and Cochlear Synaptopathy Are Mediated by the Activation of AMPK.Loss of the Par3 polarity protein promotes breast tumorigenesis and metastasis.Folliculin controls lung alveolar enlargement and epithelial cell survival through E-cadherin, LKB1, and AMPK.Inositol hexaphosphate inhibits tumor growth, vascularity, and metabolism in TRAMP mice: a multiparametric magnetic resonance study.AMPK as a metabolic tumor suppressor: control of metabolism and cell growth.Role of the energy sensor AMP-activated protein kinase in renal physiology and diseaseDevelopmental enhancement of adenylate kinase-AMPK metabolic signaling axis supports stem cell cardiac differentiation.LKB1 deletion with the RIP2.Cre transgene modifies pancreatic beta-cell morphology and enhances insulin secretion in vivo.An AMPK-independent signaling pathway downstream of the LKB1 tumor suppressor controls Snail1 and metastatic potential.Regulation of bile canalicular network formation and maintenance by AMP-activated protein kinase and LKB1.Perturbing microtubule integrity blocks AMP-activated protein kinase-induced meiotic resumption in cultured mouse oocytes.LKB1 is a central regulator of tumor initiation and pro-growth metabolism in ErbB2-mediated breast cancer.ATP synthesis and storage.The LKB1 tumor suppressor controls spindle orientation and localization of activated AMPK in mitotic epithelial cells.RIP2-mediated LKB1 deletion causes axon degeneration in the spinal cord and hind-limb paralysis.CC3/TIP30 regulates metabolic adaptation of tumor cells to glucose limitationGenetic evolution of pancreatic cancer: lessons learnt from the pancreatic cancer genome sequencing project.Molecular pathways in pancreatic carcinogenesisGenetic and molecular alterations in pancreatic cancer: implications for personalized medicine.Probucol suppresses human glioma cell proliferation in vitro via ROS production and LKB1-AMPK activationInositol pyrophosphates promote tumor growth and metastasis by antagonizing liver kinase B1Phosphorylation of LKB1/Par-4 establishes Schwann cell polarity to initiate and control myelin extentStk11 (Lkb1) deletion in the osteoblast lineage leads to high bone turnover, increased trabecular bone density and cortical porosity.Autophagy as a therapeutic target in cancer.Loss of LKB1 disrupts breast epithelial cell polarity and promotes breast cancer metastasis and invasion.Synergism between altered cortical polarity and the PI3K/TOR pathway in the suppression of tumour growth.Proteomics of Primary Cilia by Proximity LabelingLKB1 and Notch Pathways Interact and Control Biliary Morphogenesis.Akt blocks the tumor suppressor activity of LKB1 by promoting phosphorylation-dependent nuclear retention through 14-3-3 proteins.Mouse skeletal muscle fiber-type-specific macroautophagy and muscle wasting are regulated by a Fyn/STAT3/Vps34 signaling pathway
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LKB1 and AMPK family signaling: the intimate link between cell polarity and energy metabolism.
description
article científic
@ca
article scientifique
@fr
articolo scientifico
@it
artigo científico
@pt
bilimsel makale
@tr
scientific article published on July 2009
@en
vedecký článok
@sk
vetenskaplig artikel
@sv
videnskabelig artikel
@da
vědecký článek
@cs
name
LKB1 and AMPK family signaling ...... olarity and energy metabolism.
@en
LKB1 and AMPK family signaling ...... olarity and energy metabolism.
@nl
type
label
LKB1 and AMPK family signaling ...... olarity and energy metabolism.
@en
LKB1 and AMPK family signaling ...... olarity and energy metabolism.
@nl
prefLabel
LKB1 and AMPK family signaling ...... olarity and energy metabolism.
@en
LKB1 and AMPK family signaling ...... olarity and energy metabolism.
@nl
P2093
P2860
P1476
LKB1 and AMPK family signaling ...... olarity and energy metabolism.
@en
P2093
G Johan Offerhaus
Hans Clevers
Jean Paul Ten Klooster
Marnix Jansen
P2860
P304
P356
10.1152/PHYSREV.00026.2008
P577
2009-07-01T00:00:00Z