Increased sequence coverage through combined targeting of variant and conserved epitopes correlates with control of HIV replication.
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Triple Cytokine FluoroSpot Analysis of Human Antigen-Specific IFN-γ, IL-17A and IL-22 ResponsesHIV control is mediated in part by CD8+ T-cell targeting of specific epitopes.The HIV-1 antisense protein (ASP) induces CD8 T cell responses during chronic infection.CD8(+) T-cell Cytotoxic Capacity Associated with Human Immunodeficiency Virus-1 Control Can Be Mediated through Various Epitopes and Human Leukocyte Antigen TypesFitness-Balanced Escape Determines Resolution of Dynamic Founder Virus Escape Processes in HIV-1 Infection.Increased T cell breadth and antibody response elicited in prime-boost regimen by viral vector encoded homologous SIV Gag/Env in outbred CD1 mice.Conserved HIV-1 Gag p24 Epitopes Elicit Cellular Immune Responses That Impact Disease Outcome.HIV-1 epitopes presented by MHC class I types associated with superior immune containment of viremia have highly constrained fitness landscapes.Stepping up ELISpot: Multi-Level Analysis in FluoroSpot Assays
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Increased sequence coverage through combined targeting of variant and conserved epitopes correlates with control of HIV replication.
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Increased sequence coverage th ...... th control of HIV replication.
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Increased sequence coverage th ...... th control of HIV replication.
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Increased sequence coverage th ...... th control of HIV replication.
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Increased sequence coverage th ...... th control of HIV replication.
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Increased sequence coverage th ...... th control of HIV replication.
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Increased sequence coverage th ...... th control of HIV replication.
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Increased sequence coverage th ...... th control of HIV replication.
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David Heckerman
James I Mullins
Janine Maenza
Jonathan M Carlson
Julie Czartoski
Justine Sunshine
Nicole Frahm
Stephen A Migueles
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10.1128/JVI.02361-13
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2013-11-13T00:00:00Z