Drug resistance and P-glycoprotein gene amplification in the protozoan parasite Leishmania.
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Linear amplicons as precursors of amplified circles in methotrexate-resistant Leishmania tarentolaeInverted repeats as genetic elements for promoting DNA inverted duplication: implications in gene amplificationFormation of extrachromosomal circular amplicons with direct or inverted duplications in drug-resistant Leishmania tarentolaePhysiological consequences of drug resistance in Leishmania and their relevance for chemotherapyPathways of As(III) detoxification in Saccharomyces cerevisiae.Purification and characterization of ACR2p, the Saccharomyces cerevisiae arsenate reductase.Homologues of the human multidrug resistance genes MRP and MDR contribute to heavy metal resistance in the soil nematode Caenorhabditis elegansGene expression profiling and molecular characterization of antimony resistance in Leishmania amazonensisProteomic and genomic analyses of antimony resistant Leishmania infantum mutantDrug resistance in leishmaniasisInfectivity of Leishmania mexicana is associated with differential expression of protein kinase C-like triggered during a cell-cell contactAntimony transport mechanisms in resistant leishmania parasites.Selection for high-level chloroquine resistance results in deamplification of the pfmdr1 gene and increased sensitivity to mefloquine in Plasmodium falciparum.Suppression of gene amplification and chromosomal DNA integration by the DNA mismatch repair systemHeterogeneity of molecular resistance patterns in antimony-resistant field isolates of Leishmania species from the western Mediterranean area.Increased levels of thiols protect antimony unresponsive Leishmania donovani field isolates against reactive oxygen species generated by trivalent antimonyTransmembrane transport of endo- and xenobiotics by mammalian ATP-binding cassette multidrug resistance proteins.Induced resistance to methionyl-tRNA synthetase inhibitors in Trypanosoma brucei is due to overexpression of the target.Molecular characterization of the MRPA transporter and antimony uptake in four New World Leishmania spp. susceptible and resistant to antimony.Use of cysteine-reactive small molecules in drug discovery for trypanosomal disease.P-glycoproteins of Haemonchus contortus: development of real-time PCR assays for gene expression studies.A cruciform-dumbbell model for inverted dimer formation mediated by inverted repeatsRole of the locus and of the resistance gene on gene amplification frequency in methotrexate resistant Leishmania tarentolae.Selection against the dihydrofolate reductase-thymidylate synthase (DHFR-TS) locus as a probe of genetic alterations in Leishmania major.Detection of drug resistance gene in cutaneous leishmaniasis by PCR in some endemic areas of iran.Co-existence of circular and multiple linear amplicons in methotrexate-resistant LeishmaniaHomologous recombination between direct repeat sequences yields P-glycoprotein containing amplicons in arsenite resistant Leishmania.Frequent amplification of a short chain dehydrogenase gene as part of circular and linear amplicons in methotrexate resistant LeishmaniaA novel antifolate resistance gene on the amplified H circle of Leishmania.Resistance mechanisms to arsenicals and antimonials.Drug resistance in leishmaniasis.Properties of GDP-mannose pyrophosphorylase, a critical enzyme and drug target in Leishmania mexicana.
P2860
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P2860
Drug resistance and P-glycoprotein gene amplification in the protozoan parasite Leishmania.
description
article científic
@ca
article scientifique
@fr
articolo scientifico
@it
artigo científico
@pt
bilimsel makale
@tr
scientific article published on July 1991
@en
vedecký článok
@sk
vetenskaplig artikel
@sv
videnskabelig artikel
@da
vědecký článek
@cs
name
Drug resistance and P-glycopro ...... protozoan parasite Leishmania.
@en
Drug resistance and P-glycopro ...... protozoan parasite Leishmania.
@nl
type
label
Drug resistance and P-glycopro ...... protozoan parasite Leishmania.
@en
Drug resistance and P-glycopro ...... protozoan parasite Leishmania.
@nl
prefLabel
Drug resistance and P-glycopro ...... protozoan parasite Leishmania.
@en
Drug resistance and P-glycopro ...... protozoan parasite Leishmania.
@nl
P1476
Drug resistance and P-glycopro ...... protozoan parasite Leishmania.
@en
P2093
P304
P356
10.1016/0923-2508(91)90089-S
P577
1991-07-01T00:00:00Z