A novel antifolate resistance gene on the amplified H circle of Leishmania.
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Linear amplicons as precursors of amplified circles in methotrexate-resistant Leishmania tarentolaeInteractions between BRCA2 and RAD51 for promoting homologous recombination in Leishmania infantumFormation of extrachromosomal circular amplicons with direct or inverted duplications in drug-resistant Leishmania tarentolaePhysiological consequences of drug resistance in Leishmania and their relevance for chemotherapyFormation of linear inverted repeat amplicons following targeting of an essential gene in Leishmania.Multiple mutations in heterogeneous miltefosine-resistant Leishmania major population as determined by whole genome sequencingGeneration of Leishmania hybrids by whole genomic DNA transformationDevelopment of novel prime-boost strategies based on a tri-gene fusion recombinant L. tarentolae vaccine against experimental murine visceral leishmaniasisProteomic and genomic analyses of antimony resistant Leishmania infantum mutantFormation of linear amplicons with inverted duplications in Leishmania requires the MRE11 nucleaseIntrachromosomal amplification, locus deletion and point mutation in the aquaglyceroporin AQP1 gene in antimony resistant Leishmania (Viannia) guyanensisDifferential Subcellular Localization of Leishmania Alba-Domain Proteins throughout the Parasite DevelopmentDifferent Mutations in a P-type ATPase Transporter in Leishmania Parasites are Associated with Cross-resistance to Two Leading Drugs by Distinct MechanismsMembers of a large retroposon family are determinants of post-transcriptional gene expression in LeishmaniaThe role of alanine 163 in solute permeability of Leishmania major aquaglyceroporin LmAQP1A novel class of developmentally regulated noncoding RNAs in Leishmania.Live nonpathogenic parasitic vector as a candidate vaccine against visceral leishmaniasis.Trypanosoma brucei pteridine reductase 1 is essential for survival in vitro and for virulence in miceRapid decay of unstable Leishmania mRNAs bearing a conserved retroposon signature 3'-UTR motif is initiated by a site-specific endonucleolytic cleavage without prior deadenylation.Activation of phosphatidylinositol 3-kinase/Akt and impairment of nuclear factor-kappaB: molecular mechanisms behind the arrested maturation/activation state of Leishmania infantum-infected dendritic cells.The expression of biologically active human p53 in Leishmania cells: a novel eukaryotic system to produce recombinant proteinsGene amplification and point mutations in pyrimidine metabolic genes in 5-fluorouracil resistant Leishmania infantum.Defining the sequence requirements for the positioning of base J in DNA using SMRT sequencing.Roles of Rad51 paralogs for promoting homologous recombination in Leishmania infantum.PTR1: a reductase mediating salvage of oxidized pteridines and methotrexate resistance in the protozoan parasite Leishmania major.Isolation and sequence analysis of polyketide synthase genes from the daunomycin-producing Streptomyces sp. strain C5.Chromosomal Translocations in the Parasite Leishmania by a MRE11/RAD50-Independent Microhomology-Mediated End Joining MechanismModulation of Leishmania major aquaglyceroporin activity by a mitogen-activated protein kinase.Recombinant Leishmania major secreting biologically active granulocyte-macrophage colony-stimulating factor survives poorly in macrophages in vitro and delays disease development in mice.Deadenylation-independent stage-specific mRNA degradation in LeishmaniaIncreased expression of LD1 genes transcribed by RNA polymerase I in Leishmania donovani as a result of duplication into the rRNA gene locus.The unique Leishmania EIF4E4 N-terminus is a target for multiple phosphorylation events and participates in critical interactions required for translation initiation.Cos-Seq for high-throughput identification of drug target and resistance mechanisms in the protozoan parasite Leishmania.Alteration in glycerol and metalloid permeability by a single mutation in the extracellular C-loop of Leishmania major aquaglyceroporin LmAQP1.Immunogenicity and Efficacy of Live L. tarentolae Expressing KMP11-NTGP96-GFP Fusion as a Vaccine Candidate against Experimental Visceral Leishmaniasis Caused by L. infantum.Gene expression modulation is associated with gene amplification, supernumerary chromosomes and chromosome loss in antimony-resistant Leishmania infantum.Intrachromosomal tandem duplication and repeat expansion during attempts to inactivate the subtelomeric essential gene GSH1 in LeishmaniaRNA secondary structure and nucleotide composition of the conserved hallmark sequence of Leishmania SIDER2 retroposons are essential for endonucleolytic cleavage and mRNA degradation.Gene amplification in Leishmania tarentolae selected for resistance to sodium stibogluconate.Reduced infectivity of a Leishmania donovani biopterin transporter genetic mutant and its use as an attenuated strain for vaccination.
P2860
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P2860
A novel antifolate resistance gene on the amplified H circle of Leishmania.
description
1992 nî lūn-bûn
@nan
1992年の論文
@ja
1992年論文
@yue
1992年論文
@zh-hant
1992年論文
@zh-hk
1992年論文
@zh-mo
1992年論文
@zh-tw
1992年论文
@wuu
1992年论文
@zh
1992年论文
@zh-cn
name
A novel antifolate resistance gene on the amplified H circle of Leishmania.
@en
type
label
A novel antifolate resistance gene on the amplified H circle of Leishmania.
@en
prefLabel
A novel antifolate resistance gene on the amplified H circle of Leishmania.
@en
P2093
P2860
P1433
P1476
A novel antifolate resistance gene on the amplified H circle of Leishmania
@en
P2093
Ouellette M
Papadopoulou B
P2860
P304
P356
10.1002/J.1460-2075.1992.TB05444.X
P407
P577
1992-10-01T00:00:00Z