PAXX promotes KU accumulation at DNA breaks and is essential for end-joining in XLF-deficient mice.
about
Generation and CRISPR/Cas9 editing of transformed progenitor B cells as a pseudo-physiological system to study DNA repair gene function in V(D)J recombination.The Non-Homologous End Joining Protein PAXX Acts to Restrict HSV-1 Infection.Nonhomologous DNA End Joining for Repair of DNA Double-Strand Breaks.Synthetic lethality between murine DNA repair factors XLF and DNA-PKcs is rescued by inactivation of Ku70.PAXX and Xlf interplay revealed by impaired CNS development and immunodeficiency of double KO mice.Normal development of mice lacking PAXX, the paralogue of XRCC4 and XLF.Deoxyribonucleic Acid Damage and Repair: Capitalizing on Our Understanding of the Mechanisms of Maintaining Genomic Integrity for Therapeutic Purposes.Robust DNA repair in PAXX-deficient mammalian cells.C-NHEJ without indels is robust and requires synergistic function of distinct XLF domains.Dissection of DNA double-strand-break repair using novel single-molecule forcepsPAXX and its paralogs synergistically direct DNA polymerase λ activity in DNA repairPAXX Participates in Base Excision Repair via Interacting with Pol β and Contributes to TMZ Resistance in Glioma Cells
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PAXX promotes KU accumulation at DNA breaks and is essential for end-joining in XLF-deficient mice.
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article científic
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article scientifique
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articolo scientifico
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artigo científico
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bilimsel makale
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scientific article published on 04 January 2017
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vedecký článok
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vetenskaplig artikel
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videnskabelig artikel
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vědecký článek
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name
PAXX promotes KU accumulation ...... joining in XLF-deficient mice.
@en
PAXX promotes KU accumulation ...... joining in XLF-deficient mice.
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type
label
PAXX promotes KU accumulation ...... joining in XLF-deficient mice.
@en
PAXX promotes KU accumulation ...... joining in XLF-deficient mice.
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prefLabel
PAXX promotes KU accumulation ...... joining in XLF-deficient mice.
@en
PAXX promotes KU accumulation ...... joining in XLF-deficient mice.
@nl
P2093
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P356
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PAXX promotes KU accumulation ...... joining in XLF-deficient mice.
@en
P2093
Wenxia Jiang
Xiangyu Liu
Zhengping Shao
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P2888
P356
10.1038/NCOMMS13816
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P50
P577
2017-01-04T00:00:00Z