Medicinal inorganic chemistry approaches to passivation and removal of aberrant metal ions in disease.
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Drug-induced reactivation of apoptosis abrogates HIV-1 infectionTowards a unifying, systems biology understanding of large-scale cellular death and destruction caused by poorly liganded iron: Parkinson's, Huntington's, Alzheimer's, prions, bactericides, chemical toxicology and others as examplesOverview of Alzheimer's Disease and Some Therapeutic Approaches Targeting Aβ by Using Several Synthetic and Herbal CompoundsProtein misfolding and aggregation in Alzheimer's disease and type 2 diabetes mellitusCopper chelator induced efficient episodic memory recovery in a non-transgenic Alzheimer's mouse modelNMR, DFT and luminescence studies of the complexation of Al(III) with 8-hydroxyquinoline-5-sulfonate.Structural and photophysical studies on gallium(III) 8-hydroxyquinoline-5-sulfonates. Does excited state decay involve ligand photolabilisation?Synthesis and characterization of some water soluble Zn(II) complexes with (E)-N-(pyridin-2-ylmethylene)arylamines that regulate tumour cell death by interacting with DNA.Multifunctional antioxidants for the treatment of age-related diseasesA prochelator activated by hydrogen peroxide prevents metal-induced amyloid Beta aggregation.Rational design of a structural framework with potential use to develop chemical reagents that target and modulate multiple facets of Alzheimer's disease.Prochelators triggered by hydrogen peroxide provide hexadentate iron coordination to impede oxidative stressNMR, DFT and luminescence studies of the complexation of Zn(II) with 8-hydroxyquinoline-5-sulfonate.Advances in iron chelation: an update.Design of iron chelators with therapeutic application.A responsive particulate MRI contrast agent for copper(I): a cautionary taleRecent Development of Bifunctional Small Molecules to Study Metal-Amyloid-β Species in Alzheimer's DiseaseDesign of small molecules that target metal-A{beta} species and regulate metal-induced A{beta} aggregation and neurotoxicity.Molecular-level examination of Cu2+ binding structure for amyloid fibrils of 40-residue Alzheimer's β by solid-state NMR spectroscopy.Alzheimer's disease & metals: therapeutic opportunities.Misfolded proteins in Alzheimer's disease and type II diabetes.Tools of the trade: investigations into design strategies of small molecules to target components in Alzheimer's disease.A versatile water-soluble chelating and radical scavenging platform.Selective acetylcholinesterase inhibitor activated by acetylcholinesterase releases an active chelator with neurorescuing and anti-amyloid activitiesReactivity of diphenylpropynone derivatives toward metal-associated amyloid-β species.Clawing back: broadening the notion of metal chelators in medicineA magnetoplasmonic imaging agent for copper(I) with dual response by MRI and dark field microscopy.Novel metals and metal complexes as platforms for cancer therapyExploring the reactivity of flavonoid compounds with metal-associated amyloid-β species.Basis for sensitive and selective time-delayed luminescence detection of hydroxyl radical by lanthanide complexes.Application of metal coordination chemistry to explore and manipulate cell biology.The potential application of iron chelators for the treatment of neurodegenerative diseases.Metal ions, Alzheimer's disease and chelation therapy.Metal attenuating therapies in neurodegenerative disease.Chelation therapy in Wilson's disease: from D-penicillamine to the design of selective bioinspired intracellular Cu(I) chelators.Werner coordination chemistry and neurodegeneration.New horizons for diagnostics and therapeutic applications of graphene and graphene oxide.Selenoprotein P and selenoprotein M block Zn2+ -mediated Aβ42 aggregation and toxicity.3-Hydroxypyridinone derivatives as metal-sequestering agents for therapeutic use.Recent progress in repositioning Alzheimer's disease drugs based on a multitarget strategy.
P2860
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P2860
Medicinal inorganic chemistry approaches to passivation and removal of aberrant metal ions in disease.
description
article científic
@ca
article scientifique
@fr
articolo scientifico
@it
artigo científico
@pt
bilimsel makale
@tr
scientific article published on October 2009
@en
vedecký článok
@sk
vetenskaplig artikel
@sv
videnskabelig artikel
@da
vědecký článek
@cs
name
Medicinal inorganic chemistry ...... berrant metal ions in disease.
@en
Medicinal inorganic chemistry ...... berrant metal ions in disease.
@nl
type
label
Medicinal inorganic chemistry ...... berrant metal ions in disease.
@en
Medicinal inorganic chemistry ...... berrant metal ions in disease.
@nl
prefLabel
Medicinal inorganic chemistry ...... berrant metal ions in disease.
@en
Medicinal inorganic chemistry ...... berrant metal ions in disease.
@nl
P356
P1433
P1476
Medicinal inorganic chemistry ...... berrant metal ions in disease.
@en
P2093
Lauren E Scott
P304
P356
10.1021/CR9000176
P50
P577
2009-10-01T00:00:00Z