Cell-to-Cell Variation in p53 Dynamics Leads to Fractional Killing.
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Systems Approaches to Cancer BiologyRapidly cycling Lgr5+ stem cells are exquisitely sensitive to extrinsic dietary factors that modulate colon cancer risk.Dynamics of p53: A Master Decider of Cell Fate.Looking beyond the cancer cell for effective drug combinations.N-myc downstream-regulated gene 1 promotes oxaliplatin-triggered apoptosis in colorectal cancer cells via enhancing the ubiquitination of Bcl-2.Multiplexed imaging of intracellular protein networks.Two is better than one; toward a rational design of combinatorial therapy.Mechanisms of p53 Functional De-Regulation: Role of the IκB-α/p53 ComplexUniversal signal generator for dynamic cell stimulation.A dynamical framework for complex fractional killing.TSC loss distorts DNA replication programme and sensitises cells to genotoxic stressp53 pulses lead to distinct patterns of gene expression albeit similar DNA-binding dynamics.The emergence of dynamic phenotyping.Conservation and Divergence of p53 Oscillation Dynamics across Species.p53 dynamics orchestrates with binding affinity to target genes for cell fate decision.Modulation of DNA methylation by human papillomavirus E6 and E7 oncoproteins in cervical cancer.Recurring Amplification at 11q22.1-q22.2 Locus Plays an Important Role in Lymph Node Metastasis and Radioresistance in OSCC.In-Tether Chiral Center Induced Helical Peptide Modulators Target p53-MDM2/MDMX and Inhibit Tumor Growth in Stem-Like Cancer Cell.The relationship between DNA single-stranded damage response and double-stranded damage response.Understanding non-linear effects from Hill-type dynamics with application to decoding of p53 signaling.Cell-specific responses to the cytokine TGFβ are determined by variability in protein levels.Systematic Quantification of Population Cell Death Kinetics in Mammalian Cells.The impact of non-genetic heterogeneity on cancer cell death.p53 Suppresses Metabolic Stress-Induced Ferroptosis in Cancer Cells.Leveraging and coping with uncertainty in the response of individual cells to therapy.Epigenetic and Transcriptional Variability Shape Phenotypic Plasticity.Overview on Clinical Relevance of Intra-Tumor Heterogeneity.Estrogen-dependent control and cell-to-cell variability of transcriptional bursting.Microenvironmental Signals and Biochemical Information Processing: Cooperative Determinants of Intratumoral Plasticity and Heterogeneity.Integrating genomic information and signaling dynamics for efficient cancer therapy.P53 and mTOR signalling determine fitness selection through cell competition during early mouse embryonic development.6'-Hydroxy Justicidin B Triggers a Critical Imbalance in Ca2+ Homeostasis and Mitochondrion-Dependent Cell Death in Human Leukemia K562 Cells.Recent progress and open challenges in modeling p53 dynamics in single cells.Challenges of Decoding Transcription Factor Dynamics in Terms of Gene RegulationCytoplasmic FLIP(S) and nuclear FLIP(L) mediate resistance of castrate-resistant prostate cancer to apoptosis induced by IAP antagonistsCardiomyocyte gene programs encoding morphological and functional signatures in cardiac hypertrophy and failureA limited number of double-strand DNA breaks is sufficient to delay cell cycle progression
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Cell-to-Cell Variation in p53 Dynamics Leads to Fractional Killing.
description
article científic
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article scientifique
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articolo scientifico
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artigo científico
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bilimsel makale
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scientific article published on 06 April 2016
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vedecký článok
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vetenskaplig artikel
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videnskabelig artikel
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vědecký článek
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name
Cell-to-Cell Variation in p53 Dynamics Leads to Fractional Killing.
@en
Cell-to-Cell Variation in p53 Dynamics Leads to Fractional Killing.
@nl
type
label
Cell-to-Cell Variation in p53 Dynamics Leads to Fractional Killing.
@en
Cell-to-Cell Variation in p53 Dynamics Leads to Fractional Killing.
@nl
prefLabel
Cell-to-Cell Variation in p53 Dynamics Leads to Fractional Killing.
@en
Cell-to-Cell Variation in p53 Dynamics Leads to Fractional Killing.
@nl
P2093
P2860
P1433
P1476
Cell-to-Cell Variation in p53 Dynamics Leads to Fractional Killing
@en
P2093
Andrew L Paek
Galit Lahav
William C Forrester
P2860
P304
P356
10.1016/J.CELL.2016.03.025
P407
P577
2016-04-07T00:00:00Z