The supposed tumor suppressor gene WWOX is mutated in an early lethal microcephaly syndrome with epilepsy, growth retardation and retinal degeneration.
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Advancing epilepsy genetics in the genomic eraHACE1 deficiency causes an autosomal recessive neurodevelopmental syndrome.Tumor Suppressor Genes within Common Fragile Sites Are Active Players in the DNA Damage ResponseWWOX, the chromosomal fragile site FRA16D spanning gene: its role in metabolism and contribution to cancerPleiotropic Functions of Tumor Suppressor WWOX in Normal and Cancer CellsPEX6 is Expressed in Photoreceptor Cilia and Mutated in Deafblindness with Enamel Dysplasia and MicrocephalyIntegrating Diverse Types of Genomic Data to Identify Genes that Underlie Adverse Pregnancy PhenotypesHomozygous and hemizygous CNV detection from exome sequencing data in a Mendelian disease cohort.WWOX at the crossroads of cancer, metabolic syndrome related traits and CNS pathologies.WW domain-containing oxidoreductase in neuronal injury and neurological diseases.W44X mutation in the WWOX gene causes intractable seizures and developmental delay: a case reportIntroduction to a thematic issue for WWOX.Alteration of WWOX in human cancer: a clinical view.Role of WW domain proteins WWOX in development, prognosis, and treatment response of glioma.WWOX dysfunction induces sequential aggregation of TRAPPC6AΔ, TIAF1, tau and amyloid β, and causes apoptosis.Very large common fragile site genes and their potential role in cancer development.The fragile site WWOX gene and the developing brain.The Genetic Legacy of Zoroastrianism in Iran and India: Insights into Population Structure, Gene Flow, and Selection.WWOX-related encephalopathies: delineation of the phenotypical spectrum and emerging genotype-phenotype correlation.A novel whole exon deletion in WWOX gene causes early epilepsy, intellectual disability and optic atrophy.Tumor Suppressor WWOX inhibits osteosarcoma metastasis by modulating RUNX2 function.A cascade of protein aggregation bombards mitochondria for neurodegeneration and apoptosis under WWOX deficiency.Tumor suppressor WWOX moderates the mitochondrial respiratory complex.WWOX and severe autosomal recessive epileptic encephalopathy: first case in the prenatal period.Novel mutations in WWOX, RARS2, and C10orf2 genes in consanguineous Arab families with intellectual disability.Modeling WWOX Loss of Function : What Have We Learned?
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P2860
The supposed tumor suppressor gene WWOX is mutated in an early lethal microcephaly syndrome with epilepsy, growth retardation and retinal degeneration.
description
article científic
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article scientifique
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articolo scientifico
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artigo científico
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bilimsel makale
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scientific article published on 23 January 2014
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vedecký článok
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vetenskaplig artikel
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videnskabelig artikel
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vědecký článek
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name
The supposed tumor suppressor ...... tion and retinal degeneration.
@en
The supposed tumor suppressor ...... tion and retinal degeneration.
@nl
type
label
The supposed tumor suppressor ...... tion and retinal degeneration.
@en
The supposed tumor suppressor ...... tion and retinal degeneration.
@nl
prefLabel
The supposed tumor suppressor ...... tion and retinal degeneration.
@en
The supposed tumor suppressor ...... tion and retinal degeneration.
@nl
P2860
P50
P356
P1476
The supposed tumor suppressor ...... tion and retinal degeneration.
@en
P2093
Friederike Körber
Michaela Thoenes
P2860
P2888
P356
10.1186/1750-1172-9-12
P577
2014-01-23T00:00:00Z
P5875
P6179
1041571493